P. Gingivalis Antibodies Antedate Rheumatoid Arthritis Onset

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Periodontal disease, gingivitis and Porphyromonas gingivalis have been linked to the pathogenesis of rheumatoid arthritis (RA) and the production of anti-citrullinated protein antibodies (ACPA).

Is Biologic Safety Different in the Elderly?

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The factors that influence the safety of biologic therapy are numerous. Amongst them, increasing age is a potential risk factor, moreso if you also consider the polypharmacy, comorbidities and longer disease duration inherent in an elderly group of rheumatoid arthritis (RA) patients.

Risk of Sepsis or Death Lower with Biologics in Rheumatoid Arthritis

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Researchers from Germany have analyzed their large prospective rheumatoid arthritis (RA) registry to address whether being on biologic therapies leads to poorer outcomes - namely sepsis or death, following a serious infection (SIE).

RheumNow Week in Review – 5 August 2016

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Highlights from this week on RheumNow.com include:

1. Having #RA in addition to solid cancer (breast, lung, prostate, colon) increases mortality rates by 40-50% in elders https://t.co/aitjusmOai
2. The global market for rheumatoid arthritis therapies was $19.9 billion in 2015, expected to reach $21.3B by 2020 https://t.co/d2Sh5C8y9f
3. Half of doctors never heard of MACRA:Medicare Access & CHIP Reauthorization Act. Starts on Jan 1st! https://t.co/eYgWBWCw6y Blog:https://t.co/sRKZSOFyNV

And more!

Serious Infections are Not Increased in HIV Patients Treated with TNF Inhibitors

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Infections are a concern for many when using tumor necrosis factor-α inhibitor (TNFi) therapy to treat inflammatory disorders. Even moreso in those at higher risk.

Severe, Refractory Psoriasis in HIV-Positive Patients: Are TNF Inhibitors a Solution?

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Psoriasis and psoriatic arthritis are more prevalent, often more severe, and sometimes refractory to conventional treatments in HIV-positive patients, but clinicians are understandably concerned about moving on to immunosuppressive anti-tumor necrosis factor (TNF) agents when other treatments fai

Dinosaur Arthritis

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The recent edition of Science has an interesting article on the cause of death in a dinosaur - septic arthritis.

Palentologists have unearthed a 70 million year old duck-billed dinosaur near New Jersey and found that the arm bones were not quite right.  

RheumNow Week in Review - 29 July 2016

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Dr Jack Cush reviews this week's highlights from RheumNow.com.

SAPHO Syndrome Revisted

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SAPHO is an acronym that describes a constellation of findings (synovitis, acne, pustulosis, hyperostosis, and osteitis) that defines this rare syndrome. 

RheumNow Week in Review – 15 July 2016

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Dr. Jack Cush reviews highlights from this week's rheumatology news on RheumNow.com.

Gut Microbiome Shapes Risk and Response in Rheumatoid Arthritis

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In Genome Medicine, Mayo Clinic researchers investigated a cohort of rheumatoid arthritis (RA) patients, their relatives and a healthy control group analyzing the gut microbiome vial16S ribosomal DNA analysis of fecal samples.

10 Ways Rheumatoid Arthritis Could’ve Killed Glenn Frey

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I was truly stunned when it was announced that Glenn Frey, from the Eagles, had died as a result of complications from his rheumatoid arthritis, ulcerative colitis and pneumonia.

RheumNow Week in Review – 24 June 2016

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Dr. Cush reviews highlights published this week at RheumNow.com.

Infection Risk Increased in Giant Cell Arteritis

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French researchers recruited 486 patients with giant cell arteritis (GCA) from over 40 centers throughout France, and compared their outcomes to age and sex matched individuals randomly selected from the general population. Both groups were followed for 5 years and assessed for the risk of serious infections.

EULAR 2016 Drug Safety Report

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The EULAR Annual European Congress of Rheumatology meeting was held in London from June 8-11, 2016 and was well attended by thousands. This year’s meeting had over 2,000 poster displays, and the EULAR 2016 Congress presented new recommendations on the management of rheumatoid arthritis, spondyloarthritis, and fibromyalgia.

Eight Deaths Linked to Methotrexate in Australia

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Methotrexate , a cornerstone drug used to treat rheumatoid arthritis, has led to 90 hospitalizations and 7 deaths according to a recent report from the Medical Journal of Australia. 

Mosquito Arthritis

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In the last two years there have been increasing reports of mosquito-borne infectious arthritides.  Dengue fever was best known until the introduction of viral infections due to chikungunya and Zika. 

TB Management Questions

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The following is a compilation of several frequently asked questions regarding tuberculosis (TB) testing or treatment in patients on a TNF inhibitor (TNFi) or other biologic agents.

Poor Outcomes for Dermato/Polymyositis Admitted to ICU

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Idiopathic inflammatory myopathies (IIMs) may be complicated with life-threatening conditions requiring intensive care unit (ICU) admission.  The outcomes of such complications may be dire, but there are few series addressing the outcomes of those admitted to the ICU. 

RheumNow Week in Review – 22 April 2016

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Watch Dr. Jack Cush cover ten highlights from this week on RheumNow.com.