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The 12-month safety and efficacy of pegloticase + methotrexate (MTX) in the MIRROR trial shows continued efficacy and tophi resolution after 12 months of therapy.
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Treatment with at least some biologic drugs significantly reduced 1-year progression of early rheumatoid arthritis (RA) relative to classical small-molecule agents, researchers reported.
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Do abatacept, cenicriviroc, or infliximab improve time to recovery for patients hospitalized with COVID-19 pneumonia compared with standard care?
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A phase 3 trial assessed a selective Janus kinase 1/2-inhibitor, baricitinib, in patients with juvenile idiopathic arthritis (JIA), demonstrating it's efficacy and safety compared to placebo.
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Cerebrovascular ischemic events (CIE) can be one of the most severe complications of giant cell arteritis (GCA), but is seen in 4-5% of GCA patients according to a recent French University Hospital.
Dr. John Cush
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Baricitinib Effective in JIA Subsets
A phase 3 trial assessed a selective Janus kinase 1/2-inhibitor, baricitinib, in patients with juvenile idiopathic arthritis (JIA), demonstrating it's efficacy and safety compared to placebo.
https://t.co/0CMzVCgsG8 https://t.co/NGE1pxsmcb
Dr. John Cush
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Commercial claims analysis of 21,044 pts w/ simultaneous B/L TKA vs 126,264 matched unilateral TKA. 90 day risk showed B/L TKA had signif more pulmonary embolism (aOR 2.13), CVA (2.21), acute anemia (2.06), transfusion (7.8), 90d readmission (1.35) https://t.co/ZW7fa3fbfC https://t.co/nVqRospVIV
Dr. John Cush
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JAMA: Prophylaxis for Pneumocystis Pneumonia - indications and Rx
- Immuncompromised and Immunodeficient
- Pts on Hi Dose Steroids
- ANCA–associated vasculitis
https://t.co/2VhLxc4VNo https://t.co/cXuY4Manrk
Dr. John Cush
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ICYMI: ChatGPT - A Boon or Threat to Scientific Publication?
https://t.co/nt4m6n27A3 https://t.co/oo88u5X86Z
Dr. John Cush
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GCA and the Risk of Cerebrovascular Ischemic Events
Cerebrovascular ischemic events (CIE) can be one of the most severe complications of giant cell arteritis (GCA), but is seen in 4-5% of GCA patients according to a recent French University Hospital.
https://t.co/MAjgWg71vK https://t.co/UhMtiWf7gh
Dr. John Cush
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Upadacitinib Outcomes in High Risk RA Patients
A safety analysis of six phase III SELECT trials showed that higher-risk RA patients had an increased risk of MACE, malignancy (excluding NMSC) and VTE regardless of being treated with either UPA or ADA.
https://t.co/7JXntIV09K https://t.co/CthPcu2Ohs
Dr. John Cush
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A double-blind, sham-controlled RCT of auricular vagus nerve stimulation (VNS) showed NO meaningful improvement in 101 RA completers. @week 12, ACR20 was 25% for VNS vs 27% for sham (NS). Also NS was change in DAS28-CRP (–0.95 vs –0.66)(p 0.06) https://t.co/NubTu8mGq4 https://t.co/OQSIpHgLyn
Dr. John Cush
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ICYMI: Hydroxychloroquine Dose and Risk for Incident Retinopathy
A cohort study in Annals of Internal Medicine shows that higher hydroxychloroquine doses was associated with progressively greater risk for incident retinopathy.
https://t.co/SLgUKQKbFs https://t.co/xCc2D5Hx8S
Dr. John Cush
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ICYMI: 25 Great Women in Rheumatology
https://t.co/ghCAUBMMja https://t.co/cr2xI2VrgE
Dr. John Cush
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ICYMI: Carpal Tunnel - Steroid injection vs. Night Splinting
A trial conducted by the UK National Health Service, studied interventions in patients with CTS and found no advantage to either CTS CSI or NS as the initial treatment.
https://t.co/b8yZSKRK2X https://t.co/zOYaYOtuJd
Dr. John Cush
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Pain is the leading cause of disability worldwide. Chronic pain affects 33-50% of the population. High impact chronic pain is seen in 4.8% of US adult population. Chronic pain accounts for 22-50% of GP consultations. More from BMJ.. https://t.co/IRVpJZNS0L https://t.co/YVIM38aWWK
Dr. John Cush
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Full read review of "Treatments for Lupus Nephritis" from Isenberg et al - discussing:
- Pathogenesis, outcomes
- Conventional Rx
- B cell targeting: BEL, RTX, Obintuzumab, Atacicept & more
- Sequential Rx: Synviose, BEAT, BLISS-Believe
- JAKi & more https://t.co/X0xn9FeL0j https://t.co/Fiyf5Drh93
Dr. John Cush
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Bringing pivotal clinical trials to you: announcing RheumNow’s Poster Hall, featuring previously presented, sponsor-generated clinical trial posters designed to educate and inform.
https://t.co/CeLTCbB2nO https://t.co/qYXt8gCHjd
Dr. John Cush
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NIH MOST study 2093 OA pts w/ Knee Xrays/CT/Pain scores q8 mos x2 yrs. IA mineralization seen in 10% knees & assoc w/ a 2 fold higher risk of freq knee pain & OR 1.86 of freq intermit/constant pain. IA mineralz. meniscus or Jt capsule=higher odds of pain https://t.co/CacJ40DVyL https://t.co/Zhwv98d6Pe
Dr. John Cush
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Since the end of COVID, how often do you see Pharma Sales Reps (PSRs)?
