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Best of 2021: Actemra FDA Approved for Systemic Sclerosis Interstitial Lung Disease

d Jack Cush, MD

Genentech announced March 4th that the US Food and Drug Administration approved tocilizumab (Actemra) for the treatment of Systemic Sclerosis-associated Interstitial Lung Disease (SSc-ILD), specifically indicated for slowing the rate of decline in pulmonary function in adults S

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Best of 2021: EULAR Guidelines on Intraarticular Therapy

d Jack Cush, MD

EULAR has published evidence-based recommendations on the use of intra-articular therapies (IAT) based on the literature review and recommendations of a multidisciplinary international task force. These IAT recommendations apply to adult patients with peripheral arthropathies.

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Best of 2021: Rebuttals

d Kathryn H. Dao, M.D.

Since the COVID vaccine rollout, more people have been eligible to receive the vaccine. However, not everyone chooses to get one. I have heard many reasons (aka excuses) from my patients who are vaccine hesitant. 

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Metanalysis of 49 articles, 16 224 pts, F/U 105 mos. Avg daily GC dose assoc w/ overall CV events, OP w/ Fx and osteonencrosis. https://t.co/l0ggQuwaaa

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Dr. John Cush RheumNow ( View Tweet)

listen to my take on how out pt mgmnt for #immunocompromised pts can be optimized & how we MUST protect them fr #COVID19 @VuMedi linkhttps://bit.ly/3FfdYGB @RheumNow @NatalieEAzarMD @BolekBerqui @KDAO2011 @rhjeumn @CreakyJoints @AWIRGROUP @RNSociety @RheumAPP https://t.co/hKVIg8Aw2g
Leonard Calabrese LCalabreseDO ( View Tweet)
"When an unexpected event occurs, we look for stories, coincidences, supernatural causes & other forms of solace to explain something that frightens or surprises us. But unexpected events are usually caused by simple mechanisms" How we react is complicated https://t.co/HLQaqmzgV5

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Dr. John Cush RheumNow ( View Tweet)

Metanalysis of 11 studies, 46 819 participants shows low quality evidence that knee extensor muscle weakness is assoc w/ increased the odds of knee osteoarthritis in women (OR 1.85)and men (OR 1.43); also radiographic knee OA https://t.co/Md7eODvsIy

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Dr. John Cush RheumNow ( View Tweet)

AstraZeneca announced that Saphnelo (anifrolumab - Type 1 IFN receptor MAb) was recommended for approval in the EU by CHMP for the treatment of patients with systemic lupus erythematosus https://t.co/KIBWi1Nd0F

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Dr. John Cush RheumNow ( View Tweet)

Indications Awaiting In the latest podcast, Dr. Jack Cush reviews the latest news, journal reports, regulatory approvals, plus 3 new cases from rheumatologists. https://t.co/1amiQrCEWX https://t.co/YR0YSDJSg3

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Dr. John Cush RheumNow ( View Tweet)
Food for Thought: "ITIS" Diet for Patients with Rheumatoid Arthritis https://t.co/C7eTPpNyXj https://t.co/G42sbDskGW

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NSAIDS Prevent Heart Attacks in PsA https://t.co/QkJJOyK7o4 https://t.co/VDBCDHPDZ5

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Dr. John Cush RheumNow ( View Tweet)
CNS Dysfunction & Blood Brain Barrier Leakage in SLE Dr. Jack Cush reviews the ACR21 Plenary Session presentation showing half of lupus patients have cognitive deficits and that these can be correlated with brain abnormalities including BBB permeability. https://t.co/HoEhqkhVlc

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Dr. John Cush RheumNow ( View Tweet)

ICYMI: Tofacitinib 1st JAK Inhibitor Approved for Ankylosing Spondylitis The FDA approved tofacitinib (Xeljanz, Xeljanz XR) for treating active ankylosing spondylitis in adults, Pfizer announced. https://t.co/nkMJUfHF6r https://t.co/cIUMVtDIKd

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Dr. John Cush RheumNow ( View Tweet)
ICYMI: RESTORE trial: yet another failure for PRP injections for knee #OA. Study of 288 Knee oA over 50 years - knee pain scores of −2.1 vs −1.8 on an 11-point scale (range, 0-10) and no difference between PRP and PBO at 12 moshttps://bit.ly/3p6GMf5

Dr. John Cush RheumNow ( View Tweet)

ICYMI: NEJM Clinical Images - Tongue Necrosis in Giant Cell Arteritis. 74-yoF w/ 3-day hx of HA and tongue swelling/pain, & blindness in the right eye. Tongue was ulcerated, R temporal artery thickened. ESR 42 CRP 169 mg/L. Read rest of story... https://t.co/ubqxhkvmY7 https://t.co/NAAD62XjpY

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ICYMI: Rinvoq FDA Approved for Active Psoriatic Arthritis https://t.co/1ysUj0GUqw https://t.co/fmDA9UyFY3

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Dr. John Cush RheumNow ( View Tweet)
🆕 Myositis Specific Antibodies (MSAs): Clinical Features and Treatment for #Myositis/IIM 💪🏽 💪🏻Proximal Muscle Weakness 🫁 Interstitial Lung Disease 🤚🏽 Cutaneous [Dermatomyositis] #RheumTwitter #DermTwitter #PulmTwitter #MedEd https://t.co/TCwpLI1yNr
Mithu Maheswaranathan, MD MithuRheum ( View Tweet)
Risk and prognosis of SARS-CoV-2 infection and vaccination against SARS-CoV-2 in rheumatic and musculoskeletal diseases: a systematic literature review to inform EULAR recommendations https://t.co/ljqEjZNwx5 https://t.co/8fVIskV3gd

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Pedro Machado pedrommcmachado ( View Tweet)
ICYMI: Increased risk death in 310 scleroderma pts: 63 diffuse SSc, 279 limited dz & 33 sine scleroderma (SMR = 1.88). Reduced survival at 10 yrs (78%) & 15 yrs(61%). 69 deaths, 46% in diffuse PSS - due to ILD, PHA, and GI involvement https://t.co/OZg8QamhEB

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Dr. John Cush RheumNow ( View Tweet)

There's good news and bad news in rheumatology fellowship matching for 2022. There's also new FDA approvals and indications, but a new serious safety warning has arisen from the CDC about the J&J COVID-19 vaccine. All that a more on this week’s podcast. https://t.co/gklOK2S1QC https://t.co/QrYg1QZKhJ

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