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Dr Oster presenting on IL-23 inhibitor Risankizumab in PsA. No surprises here, it works. We need comparative efficacy trials! Abstr#0453 #ACR21 @RheumNow https://t.co/mj8TeCqEcg
Richard Conway RichardPAConway ( View Tweet)
Diabetes puts you at risk of cardiovascular disease, right?
What about RA?
Look at this graph and compare the pair.
"already it was impossible to say which was which” - George Orwell, Animal Farm
#ACR21 ABST0287 @RheumNow https://t.co/r0yaeC530l https://t.co/mKJhoyJ2Cn
David Liew drdavidliew ( View Tweet)
Year 2 f/u on PsA, axSpA, or RA using CT-P13, an infliximab (IFX) biosimilar. Pts either naive to IFX or switched from IFX:
💠IFX-naive: improved disease activity
💠IFX-switched: maintained stable disease
💠No new safety concerns
https://t.co/VGBicnq15w
#ACR21 Abst#0817 @RheumNow
Pedro Castillo _Castillo_Pedro ( View Tweet)
Small but important study of LN Class III, IV, and/or V with 6/18 pts considered complete responders by UProt (<500mg/g) continued to⬇️in renal fxn over 5 yrs. Bottom line: even dramatic ⬇️UProt does not tell the whole story.
https://t.co/51x4DlXkJC
#ACR21 Abst#1284 @RheumNow
Pedro Castillo _Castillo_Pedro ( View Tweet)
Infxn risk of 1st year on rituximab for mod to severe SLE vs standard-of-care
🔹Most common SoC Rx: MMF, Aza, and/or cyclophosphamide
🔹🚫significant diff
🔹RTX pts = ⬆️dz duration, ⬆️# of prior meds, ⬇️maintenance steroid dose
https://t.co/AYQFXqlubl
#ACR21 Abst1288 @RheumNow
Pedro Castillo _Castillo_Pedro ( View Tweet)
SLE: Belimumab + standard rx significantly⬇️risk of severe flares vs placebo.
Greatest in those with:
🔹+dsDNA
🔹low C3 or C4
🔹SLICC/ACR Damage index of 0 (argument for early treatment!)
https://t.co/UcGXEklqwJ
#ACR21 Abst#1295
@RheumNow
Pedro Castillo _Castillo_Pedro ( View Tweet)
Dr. Eric Ruderman gives his perspective on PsA data presented during the plenary session on Saturday at the #ACR21 annual meeting.
https://t.co/r9FgBO6VT7 https://t.co/JbV519XQoG
Links:
Dr. John Cush RheumNow ( View Tweet)
Important differences between vascular pathologies seen in #COVID19 and DIC by Dr. D McGonagle
👉Fibrinogen - normal/sl. ⬆ in PIC-assoc'd COVID19 vs. ⬇ in DIC sec to MAS
@RheumNow #ACR21 #MedTwitter
📌https://t.co/DdmAhVIR51 https://t.co/Xw8LKaKcFd
Links:
sheila RHEUMarampa ( View Tweet)
Dr. D.McGonagle on the patterns of dse ➡true #vasculitis vs. vasculitis mimics seen in skin of #COVID19 pts in this very informative slide
🔴Mild/no lung dse: vasc cuffing,⬆type1 IFN
🔴Severe dse: vasc occlusion,⬇type1 IFN
@RheumNow #ACR21 #MedTwitter
https://t.co/Y5S2k7LO1p https://t.co/puBJm4Kd8H
Links:
sheila RHEUMarampa ( View Tweet)
Interesting twist to an #ACR21 keynote lecture: Q&A!👏👏@DoctorYasmin
She even eloquently explained the etymology of crisis-the point in a pt's illness where they might rapidly deteriorate or recover, an inflection point (so relevant now) 👉to a new BETTER normal
@RheumNow https://t.co/UMKIC1tNos
sheila RHEUMarampa ( View Tweet)
#ACR21 #YearinReview
Avacopan: The game changer for ANCA #vasculitis?🧐
🔅Remission at wk 26: Avacopan non-inferior to Pred (72.3% vs. 70.1%, p<0.001)
🔅Sustained remission at wk 56: Avacopan non-inferior to Pred (65.7% vs. 54.9%, p<0.001)
@RheumNow
https://t.co/CpPYVvRoMR https://t.co/QnsZIUQ0uu
Links:
sheila RHEUMarampa ( View Tweet)
The AURORA 1 trial provided positive results for #lupus nephritis 👉rapid control of proteinuria w/o major side effects.
@RheumNow #ACR21 #YearinReview https://t.co/BWWZJtMPK0
sheila RHEUMarampa ( View Tweet)
To cut back or continue? 🤔
The ARCTIC REWIND trial showed that RA pts in remission given half dose csDMARDs had ⬆ flares in 12 mos vs. stable dose csDMARD grp.
@RheumNow #ACR21 #YearinReview https://t.co/MXyD0epVcn
sheila RHEUMarampa ( View Tweet)
Excited for the first full day of #ACR21, reporting for @RheumNow!
Esp looking forward to:
⭐Posters: #Epidemiology, #PublicHealth, #COVID19, #SpA, #RheumatoidArthritis, #PatientOutcomes
⭐Plenary session
⭐Scientific sessions covering #axSpA, #PsA and more
Mrinalini Dey DrMiniDey ( View Tweet)
Some great #SpA posters on #WorkParticipation
#ACR21
Abs#0358
•~700 pts
•379 (64.2%) took sick leave in last 12m
•#Absenteeism in 23.7% & #presenteeism in 84.1%
•Huge impact on work participation in SpA despite incr no. of therapeutic agents
@RheumNow
https://t.co/pwz4s8D1FU https://t.co/wpbjeXNpgm
Mrinalini Dey DrMiniDey ( View Tweet)
#ACR21 1st/2 abstracts by @ElenaNikiUK on #work & #sickleave in #SpA
Abs#0380
•~700pts
•Old age & high disease activity👉🏼 ⬆️risk of sick leave
•Must address #socioeconomic factors w/ disease activity to improve work outcomes in #SpA
@RheumNow #ACRBest
https://t.co/uixuGGEFJG https://t.co/WZoqWLaY1Q
Mrinalini Dey DrMiniDey ( View Tweet)
#ACR21 2nd abstract #0381 from #DESIR cohort by @ElenaNikiUK:
•High disease activity & decreased function assoc w/ greater #WorkDisability
•Not enough to just treat the disease! Need holistic approaches to improve function, QoL & work outcomes.
@RheumNow
https://t.co/jIs3Oj7nbJ
Mrinalini Dey DrMiniDey ( View Tweet)
#ACR21 Abs#0101 on recombinant #zoster vaccine (RZV) in #IMIDs:
•High proportion of ≥50yos w/ IMIDs received RZV but 15–25% did not get 2nd dose within 6m
•#Vaccination higher in ≥65yos than 50–64yos
•Need better vaccine policy to encourage uptake in pts w/ IMIDs
@RheumNow https://t.co/i5JDJClTyQ
Mrinalini Dey DrMiniDey ( View Tweet)
Freq & severity of adverse events after #SARSCoV2 #vaccine in patients with autoimmune disease vs controls Abs#0104 #ACR21
•No incr. risk of AEs in autoimmune disease vs controls
•Minimal impact of vaccines on disease activity
@RheumNow
https://t.co/jGXP5UL4LP https://t.co/980NLWQYeX
Mrinalini Dey DrMiniDey ( View Tweet)
Well done 👏@DrCMcMaster @victor_yang1 on this great work - using machine learning to pick apart GCA from its mimics.
Predicting mimics improves prediction, especially in the quagmire of biopsy-negative GCA
(also excellent memes in this Twitter thread)
#ACR21 ABST1417 @RheumNow https://t.co/cS3fMLwem4
David Liew drdavidliew ( View Tweet)