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Dot the "i", Cross the "t" (10.11.2024)
Dr. Jack Cush reviews the news and journal articles from the past week on RheumNow.com. Today’s reports suggest where to look for help, especially with regard to pain.
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Screening to Prevent Multimorbidity in Rheumatic Patients
A population based screening program of patients with chronic inflammatory rheumatic diseases (IRD) demonstrates that systematic screening IRD patients for multimorbidity increased preventive interventions and reduced hospital admissions.
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GI Abnormalities in Scleroderma
A prospective Scleroderma Cohort Study found that gastrointestinal tract (GIT) involvement was common and negatively impacted quality of life, physical function, and employment, but had no effect on mortality.
ED Delays and Hip Fracture Mortality Risk
Waiting more than 4 hours in emergency care for treatment is linked to heightened risks of death and a longer hospital stay for hip fracture patients, reveals a single centre study, published online in Eme
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Mindfulness in Managing Chronic Pain
JAMA reports that outpatient resource mindfulness-based interventions (MBIs) delivered via telehealth are effective in managing chronic pain amongst veterans.
The challenge of mindfulness interventions is often the access, availability and dedicated space for trained instructors.
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ED Delays and Hip Fracture Mortality Risk
Waiting more than 4 hours in emergency care for treatment is linked to heightened risks of death and a longer hospital stay for hip fracture patients, reveals a single centre study, published online in Emergency Medicine Journal.… https://t.co/ZaIEkb7Lo5 https://t.co/P15DrXMbnj
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UK Biobank study of 391 481 individuals found that a high polygenic risk score (PRS) for Hidradenitis suppurativa (HS) was assoc w/ increased risk of incident coronary artery Dz, diabetes, High LDL/TG and CRP https://t.co/ZS4w4hooKB https://t.co/DUXoFHMBqR
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University cohort study of 673 adults w/ CLE or dermatomyositis finds that 32% take herbal supplements, esp in younger & Hispanic pts. 31% of DM experienced Dz onset or flare after supplements (vs 10% in CLE). Elderberry had highest risk of exacerbation https://t.co/BZluGYzr3t https://t.co/5zJD7AwwNK
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Leiden Early Arthritis Clinic study (2011-17) of 431 pts found when RA is Dx in <12 wks, treatment costs were lower in Seropositive & negative RA. If Dx after 12wks, costs 316% higher in seronegative and 19% higher is autoantibody-positive RA pts https://t.co/I8QqZxIChW. https://t.co/8CRpqRiscz
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A CATCH study of 2052 early RA (ERA) pts found high incidence of hypertension (26%) with the highest risk in older patients with traditional cardiovascular risk factors. Those without HTN, at enrolment, 24% developed HTN after median follow-upof 5 years. https://t.co/8MmU60MK8v https://t.co/LyxSssXKLo
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World renowned faculty delivering state of the art lectures. Early bird registration for RheumNow Live is now open!
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What happens when "...When the person you could have been meets the person you are becoming" - Seth Godin https://t.co/RJOqNJvxwJ https://t.co/eBUc8V0Wdi
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Cancer risk increased following, but not before, a systemic sclerosis diagnosis. From a dataset of 10.1 million individuals, 1588 Dx w/ SSc & 206 developed cancer. Most common mucocutaneous (4.5%), lung (2%) breast (2%). Cancer risk higher after the Dx of SSc (HR ~1.4)… https://t.co/9GNMOU28TQ https://t.co/czLEsXymIv
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Mindfulness in Managing Chronic Pain
JAMA reports that outpatient resource mindfulness-based interventions (MBIs) delivered via telehealth are effective in managing chronic pain amongst veterans.
https://t.co/ytSb03h0Fd https://t.co/vWKvYW9Udb
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Artificial Intelligence in Diagnosing Sacroiliac Inflammation in axSpA
A so-called deep learning artificial intelligence (AI) algorithm for analyzing MRI scans showed "acceptable" agreement with expert human readers for detecting sacroiliac joint (SIJ) inflammation in patients… https://t.co/nKbYF603ut https://t.co/Y5IzVIG2l3
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Mucosal Disruptions as Initiators of Rheumatoid Arthritis
The microbiome and mucosal disruptions are believed to play a role in autoimmunity, particularly rheumatoid arthritis (RA). This is linked to the "mucosal hypothesis" of RA. A recent review by Hollers, et al. discusses… https://t.co/79khnkajMy https://t.co/UvZWwJ3ERg
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Analgesic Prescribing in Patients with Inflammatory Arthritis
A UK cross-sectional EHR clinical practice analysis between 2004 and 2020 shows that analgesic prescribing in inflammatory arthritis (IA) patients has declined, but still remains substantial, including opioid… https://t.co/K43YERU3rf https://t.co/DRZ4r9JDSv
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JCI article on Mechanisms underlying sex differences in autoimmunity - factors include sex hormones, X chromosome genes, sex-specific epigenetic effects of estrogen & environment, and microRNA effects. Also mitochondria & autoantibodies discussed https://t.co/hTrizE8jFK https://t.co/VixAZsYBzb
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Appraisal of 2023 ACR RA-ILD guidelines (based on only 3 RCTs). Conditional Recs for MMF, AZA, RTX as 1st-line RA-ILD Rx. W/ RA-ILD progression, options include MMF, RTX, nintedanib, TCZ, CTX, & pirfenidone are conditionally recommended https://t.co/9M3XykPQIi https://t.co/S0TMCsVd4y
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French cohort study shows that epidermal necrolysis (EN) is a rare, but assoc w/ high rates of in-hospital and postdischarge mortality, esp in elderly and those w/ comorbid conditions. https://t.co/BaMZmer0Fa https://t.co/mrUO419GLP
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