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Hydroxychloroquine: 5 mg/kg/day Is Only the Starting Point

Shivani Garg, MD, PhD, , Donald Thomas, MD, FACP, FACR, RhMSUS May 20, 2026

Hydroxychloroquine (HCQ) is one of the most important drugs in rheumatology, especially for systemic lupus erythematosus (SLE). It reduces flares, organ damage, cardiovascular events, and pregnancy complications, and it improves survival.

Article

Immune-Mediated Inflammatory Diseases Following Uveitis

Jack Cush, MD May 19, 2026

A Korean insurance claims data study showed children and adolescents diagnosed with uveitis have a 7-fold increased risk of developing an immune-mediated inflammatory disorder (IMID).

Article

Does Exercise and Lifestyle Modification Improve RA?

Jack Cush, MD May 19, 2026

Does exercise or lifestyle modifications reduce the risk of getting rheumatoid arthritis (RA) or change those with early RA?

Article

ABA versus HCQ in Palindromic Rheumatism

Jack Cush, MD May 18, 2026

Palindromic rheumatism may develop rheumatoid arthritis (RA) and could be an at-risk population. A pilot trial compared abatacept (ABA) versus hydroxychloroquine and demonstrated ABA reduces RA development in a 2 year study.

Israel study 264,858 pregnancies- 1st trimester NSAID exposure had no risk of congenital malformations (MCM). 8% exposed vs unexposed: overall MCM 8.2% v 7%; aRR 0.99). MCMs not incr = MSK, CV, CNS, cleft palate, GI, GU, nonsignif MSM aRR from 0.77- 1.05 https://t.co/ytYhBFl44o https://t.co/1fq4D1KykM

First-trimester nonsteroidal anti-inflammatory drugs exposure and risk of major…

ABA versus HCQ in Palindromic Rheumatism Palindromic rheumatism may develop rheumatoid arthritis (RA) and could be an at-risk population. A pilot trial compared abatacept (ABA) versus hydroxychloroquine and demonstrated ABA reduces RA development in a 2 year study. https://t.co/z0ptEYdhQj

APR: Fibromyalgia Dr. Jack Cush reviews Fibromyalgia as part of the Advanced Practice Rheum video series. https://t.co/jq6dSXy6SU https://t.co/bDGRhhY2D9

APR: Fibromyalgia | RheumNow

In this week's RheumIQ quiz: An RA patient has a current or new cancer. With which cancer should you avoid/stop the use of a TNF inhibitor? See if you got it right at https://t.co/DTabBEfjj9 https://t.co/tVYUEjAPy3

RheumIQ Weekly Quiz | RheumNow

Study of 305 newly Dx axSpA pts (age 38 yrs; 55% male, Dx delay 6yrs, 75% B27+). Clinical Dx, without Xray/imaging in 12%, 5% developed sacroiliitis during 8 yr F/U. r-axSpA mostly male w/ ^CRP https://t.co/zGjb3uSkjP https://t.co/3bdGAvKXAm

Insights into axial spondyloarthritis features and the development of imaging e…

Medical Economics reports only 18% MDs practiced in MD-owned settings, a new low. By Jan '26 hospitals or corporate employment rose to 550,494 & independent MDs fell to 120,900 https://t.co/l0tt3yO9kt https://t.co/pkgmHFPjE1

Physician independence vanishes as corporate medicine swallows up U.S. health c…

Depression screening (PHQ-8) equally accurate in pts w/ & w/o chronic pain. Depression screening is not biased by overlapping symptoms in depression and chronic pain. https://t.co/UWf97NDPAK https://t.co/7dvt35RT9E

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Infectious Rheumatology (5.15.2026) Dr. Jack Cush discusses his favorite journal articles from the past week on RheumNow. https://t.co/MzqDykG78w https://t.co/z7BsADXo4x

Infectious Rheumatology (5.15.2026) | RheumNow

Update on Multicentric Reticulohistiocytosis Have you ever seen multicentric reticulohistiocytosis (MRH)? Don't worry, it's a rare non-Langerhans cell histiocytosis condition characterized by papulonodular skin lesions and symmetric erosive polyarthritis, and it has only been https://t.co/koXOwktDgA

FDA has approved benralizumab (Fasenra) for the treatment of adult and pediatric patients w/ hypereosinophilic syndrome (HES); based on the NATRON Phase III trial https://t.co/qqPsjhUClP https://t.co/lCZNoTh9fv

FASENRA approved in US for hypereosinophilic syndrome

ANCA-Assoc. Vasculitis has great Rx optionis, BUT still no reliable biomaker to predict relapse or renal outcomes, this includes IL-6. But there is hope for CD163 in the future. https://t.co/lFyfTPj5vG https://t.co/wLfOPz76JC

Anti-neutrophil cytoplasmic antibody-associated vasculitis: biological insights…

10yr retrosp. study of 110 Still’s dz pts. MAS occurred in 37% (1/2 @onset; assoc w/ serositis) and ILD observed in 82% (also assoc w/ MAS, polycyclic course) https://t.co/SNa0KiWfgY https://t.co/xbpCuHdJka

Clinical course, complications and treatment outcomes in Still’s disease: a 10-…

Another IL-17A inhibitor (Vunakizumab) for active Ankylosing Spondylitis Vunakizumab, a novel anti–interleukin (IL) 17A monoclonal antibody, was studied in patients with active radiographic axial spondyloarthritis [r-axSpA] and found to be effective and tolerable. https://t.co/y0mw7tRWbs

Fatigue in SLE An NIH lupus cohort study looked at fatigue in SLE and found associations with organ damage, obesity, but does not correlate with disease activity in systemic lupus erythematosus (SLE) patients. https://t.co/JEAnhMFJD8 https://t.co/sROKzsyISl

Fatigue in SLE | RheumNow

"Everything will be alright in the end; and if its not alright, then its not yet the end" – Suni Kapoor Best exotic Marigold Hotel https://t.co/Yua7t4yoZe

Registry of 587 #SLE pts. 30% were RNP+ --> more dz activity than RNP- (SLEDAI-2 8.0 vs 4.0) and more Rx use (daily GC 6.8 vs 3 mg). RNP+ more renal, skin & serologic activity & less likely to LLDAS (20% vs 32%) or REM (12% vs 23%). RNP + 18-fold more likely to be Sm+ https://t.co/9i3BBGA0uu

Topics

All News

Hydroxychloroquine: 5 mg/kg/day Is Only the Starting Point

Immune-Mediated Inflammatory Diseases Following Uveitis

Does Exercise and Lifestyle Modification Improve RA?

ABA versus HCQ in Palindromic Rheumatism

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