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The degree to which the oral rheumatology drug tofacitinib (Xeljanz) seems to promote new malignancies is now fleshed out in the latest, and at least somewhat reassuring, report from a landmark safety study.
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Bimekizumab, a selective inhibitor of interleukin (IL)-17F and IL-17, has shown superior efficacy and safety in a 16 week trial in patients with active psoriatic arthritis who previously failed therapy with tumour necrosis factor-α (TNFi) inhibitors.
Dr. John Cush
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A Multidimensional Approach in the Management of Axial Spondylarthritis
Abstract 1510 by Jones et al studied the effect of lifestyle on treatment response in patients with axial spondylarthritis.
https://t.co/Y5syU5cX6Y https://t.co/PO7TZ3ZBOo
Dr. John Cush
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Visit our podcast channel and listen to experts from the #SLEEducatorsNetwork discuss how biologic therapies could help address key unmet needs in #lupus, and how clinicians can identify the most appropriate patients for biologics.
#SponsoredbyGSKUSMA
https://t.co/zYB48YvNDC https://t.co/gL67G5jQv8
Dr. John Cush
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Review of 120 pts w/ Catastrophic antiphospholipid syndrome showed that 54% had skin involvement & was 1st APS sx in 35%. Findings: livedo racemosa (45%), necrosis/ulcers (42%), splinter hemorrhages (29%), distal edema (23%), purpura (14%). https://t.co/zFsPUdo4Wb https://t.co/rEN4yfoP9h
Dr. John Cush
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Sparks editorial -- RA pathogenesis has been linked to pollution, Lung Dz, smoking, silica dust, asbestos, textile dust, brick/concrete laying, pesticides, military burn pits - some w/ strong associ w/ HLA-SE and ACPA, but not ACPA-negative RA https://t.co/ZStmF8MeLD https://t.co/xQxJ74aQ81
Dr. John Cush
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SLE: Variability in Racial Disparities in Pregnancy Outcomes
Significant disparities exist in pregnancy outcomes in women with SLE, w/previous cohorts identifying Black women as having a higher risk of maternal mortality compared to White women w/SLE.
https://t.co/1PrJYpMcHx https://t.co/YN7K0Gf5Jl
Dr. John Cush
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Tapering Methotrexate with Biologics or JAK Inhibitors in RA
Dr Segan ( @JulianSegan) discusses Abstract 0916 at #ACR22.
https://t.co/CUjZ7SiSoE https://t.co/VYtmCIJEt6
Dr. John Cush
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Lifestyle Modifications may enhance TNF Inhibitors in axSpA
https://t.co/0O4jd3g0WL https://t.co/zUaRUR9tGL
Dr. John Cush
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The Top 10 Research Priorities in Psoriatic Arthritis
A survey of 317 carers and clinicians focused on psoriatic arthritis has set an agenda of the top 10 research questions for psoriatic arthritis (PsA).
https://t.co/zfivHvtLX9 https://t.co/LZsiE417w2
Dr. John Cush
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Multi-ancestry analysis reveals novel genetic loci associated with OA
https://t.co/AIo3il8uHP https://t.co/nXGtOCCZsA
Dr. John Cush
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Systematic review comparing MIS-C and Kawasaki: 14 studies, 2928 pts; major differences- KD pts were younger; MIS-C had more Pulm, GI, Shock, more cardiac (LV, valvular pericarditis, myocarditis), but less coronary lesions & conjunctivitis https://t.co/bcCRh5HxL7 https://t.co/qLvfCYwx9u
Dr. John Cush
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Comparing Biosimilar Growth in the US, Germany, and Switzerland
The biosimilar landscape will change dramatically in 2023, following the successful rollouts in other countries in Europe.
https://t.co/LYcG0BNO6C https://t.co/V2m8HoIWLF
Dr. John Cush
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GCA: What we feel and what we can't
Dr. David Liew ( @drdavidliew) discusses Abstracts 0483 and 0486 at #ACR22 Convergence.
https://t.co/Pobsb2anLa https://t.co/RQS4N3TqgK
Dr. John Cush
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Timely Fetal Screening Important in Positive Anti-Ro Antibody Pregnancies
Dr. Yusof ( @Yuz6Yusof) discusses Abstract 0957 presented at #ACR22.
https://t.co/yl4K7jZMGr https://t.co/6733AEhRyX
Dr. John Cush
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Imaging in PMR
One of the major limitations of PMR management is the lack of a gold standard investigation or biomarker of disease activity.
https://t.co/sZtgWKAtFv https://t.co/4H4tAY6CIZ
Dr. John Cush
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Why treatment of pre-RA isn't ready for prime time
The ACR Great Debate was on "To treat or not to treat in pre-RA?" and it was stressed that autoimmunity may start well before clinical symptoms occur.
https://t.co/A0dx3PFyiJ https://t.co/wqBuM8XD7M
Dr. John Cush
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Familial Mediterranean Fever mimics
Dr Baspinar et al. performed a large case-control study in Turkey to assess whether acute abdomen episodes which led to appendectomies could be misdiagnosed as appendicitis rather than FMF-associated serositis.#ACR22
https… https://t.co/fHgeoLjNOu
Dr. John Cush
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Hydroxychloroquine: Cumulative Doses and Thresholds
Dr. Sheila Reyes ( @RHEUMarampa) discusses Abstracts 0982 and 0344 at #ACR22 Convergence.
https://t.co/k33LUNnTmV https://t.co/AJSBdT4rJC
Dr. John Cush
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Spondyloarthritis: Novel Therapies, Diagnostic Dilemmas and Depression
Dr. Lianne Gensler ( @lianegensler discusses the following abstracts presented at #ACR22. Abstracts 1597, 1598, 1599 (treatment) and 1613, 1609 and 1614 (diagnosis and outcomes)
https://t.co/0wCxKyFM0u https://t.co/8vaZ1ZncjF
