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Rheumatoid Poor Outcomes Not Linked to Comorbidity
Disease activity leads to poor outcomes; but does comorbidity add to this? A recent analysis suggests that while comorbidities do not affect long-term, functional outcomes, sociodemographic factors do affect outcomes in rheumatoid Arthritis (RA).
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DMARD Effects on COVID-19 Outcomes
Sparks and colleagues have published data from the Global Rheumatology Alliance noting that among rheumatoid arthritis (RA) patients afflicted with COVID-19 infection, there was little influence of their baseline biologic or targeted synthetic (b/ts) disease-modifying antirheumatic drug
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CMAJ: nice full read review of biologic use during pregnancy.
1) autoimmune/arthritis pts may use biologics during pregnancy
2) mom/infant should avoid live vax 1st 6–12 mos
3) Minimal biologic transfer in breast milk
4) no risk of congenital anomalies
https://t.co/mlZTrDjXSi
Links:
Dr. John Cush RheumNow ( View Tweet)
Top 10 things you should know about THE EYE in your rheumatology practice @CRASCRRheum
#uveitisclinic
#uveitisrheumatologyclinic
#kensingtoneyeinstitute https://t.co/SqRKOYa2N0
Vanessa Ocampo - MD DrDDRheum ( View Tweet)
Another report of JAK inhibitor working in GVHD - Successful treatmente of joint & fascial involvement in GVHD with baricitinib. https://t.co/TQlPLCD2T7 https://t.co/474GpFKBo2
Dr. John Cush RheumNow ( View Tweet)
New ACR Rheumatoid Arthritis Guideline: Emphasis on Methotrexate
The ACR has issued new guidelines on the treatment of RA, addressing questions about initial treatment with methotrexate and minimizing reliance on glucocorticoids.
https://t.co/J9wmcZr17D https://t.co/Tf3G9sFgm9
Links:
Dr. John Cush RheumNow ( View Tweet)
Former Rheumatologist Settles Civil Fraud Claims for $2 Million for alleged False Claims Act violations. Charges were based on claims for improper medical treatments and false billing to a federal program. https://t.co/HZwrwDrkVk
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Dr. John Cush RheumNow ( View Tweet)
ICYMI: Neuropsychiatric Events Common in Lupus
Neuropsychiatric (NP-SLE) or CNS lupus events range from mild to severe; several recent studies have noted that NPS lupus is common and should be screened for.
https://t.co/cBDZI8OLKD https://t.co/on4fA3P9GS
Links:
Dr. John Cush RheumNow ( View Tweet)
Fracture Risk with Low Dose Steroid
A large RA cohort analysis shows that low-dose glucocorticoid therapy in rheumatoid arthritis (RA) patients may carry an increased risk of vertebral osteoporotic (OP) fractures.
https://t.co/HcYpx8IDcB https://t.co/iVPjJHLNBX
Links:
Dr. John Cush RheumNow ( View Tweet)
Recent review of the epidemiology of rare Autoimmune Liver disease (PBC, PSC, AIH) shows prevalence (per 100 000) to( vary for PBC (1.91 to 40.2), for PSC (0.78 and 31.7) and for AIH (4.8 to 42.9/100,000) https://t.co/XbRYV5Qlwa
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Dr. John Cush RheumNow ( View Tweet)
Dutch study of 644 t Early Psoriatic Arthritis pts shows that 17% had no psoriasis (PASI = 0), 71% had mild psoriasis (PASI < 7), 9% moderate psoriasis (7–12) and 4% had severe psoriasis (PASI > 12). PASI didnt fluctuate much in 1st year https://t.co/XW3QhJ65Oz
Links:
Dr. John Cush RheumNow ( View Tweet)
#ClinicalPearl Palmar erythema in #SLE #lupus is sometimes painful, may not be fixed and also may have erythema of distal fingers on flexor side https://t.co/C5mysB8pFS
Janet Pope Janetbirdope ( View Tweet)
ICYMI: Metanalysis of Tramadol efficacy & safety in knee or hip #OA. 6 RCTs (3,611 pts) showed little clinical benefit w/ 100/d or 200 mg/d; only 300mg/d was better vs PBO at pain & functional improvement. All doses had higher risk of GI, CNS AEs & W/D https://t.co/wDLHFQWFOe https://t.co/l4B83eUQrW
Links:
Dr. John Cush RheumNow ( View Tweet)
ICYMI: New-Onset IBD & IL-17 Inhibitors: What’s the Risk?
https://t.co/zXDQotDiWV
Patients w/ inflammatory/autoimmune diseases who initiated treatment w/ IL-17 inhibitors didnt have a higher risk for development of IBD, but only based on the severity of their underlying disease https://t.co/w3IpQkzmn7
Links:
Dr. John Cush RheumNow ( View Tweet)
ICYMI: FDA Approves IVIG in Dermatomyositis
https://t.co/BZsl8a6ArW
The FDA has approved Octagam 10% [Immune Globulin Intravenous (Human)], as the first and only intravenous immunoglobulin (IVIg) formulation to be approved for adult dermatomyositis (DM). https://t.co/VFF0QMqbin
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Dr. John Cush RheumNow ( View Tweet)
Fracture Risk with Low Dose Steroid
https://t.co/HcYpx8IDcB
A large RA cohort analysis shows that low-dose glucocorticoid therapy in rheumatoid arthritis (RA) patients may carry an increased risk of vertebral osteoporotic (OP) fractures. https://t.co/1bc5nyZUzG
Links:
Dr. John Cush RheumNow ( View Tweet)
Tofacitinib Efficacy in Ankylosing Spondylitis
https://t.co/SEKa5OnB50
Deodhar and colleagues have published the results of a study showing that in adult patients with active ankylosing spondylitis (AS), oral tofacitinib was effective (versus placebo) and safe. https://t.co/Wb19EJQZHN
Links:
Dr. John Cush RheumNow ( View Tweet)
Growing Cannabis Use in Arthritis Patients
The National Databank for Rheumatic Diseases reports a significant increased in cannabis use amongst arthritis patients between 2014-2019.
https://t.co/9YyYB75GuN https://t.co/Xs24kBLmeg
Links:
Dr. John Cush RheumNow ( View Tweet)
New-Onset IBD and IL-17 Inhibitors: What Is the Risk?
https://t.co/zXDQotDiWV
Patients w/ inflammatory/autoimmune diseases who initiated treatment w/ IL-17 inhibitors didnt have a higher risk for development of IBD, but only based on the severity of their underlying disease https://t.co/hbWf45pQWt
Links:
Dr. John Cush RheumNow ( View Tweet)
Steroid (GC) withdrawal studied in T2T RA cohort of 207 RA pts (F/U 39 mos); Only 60% discontinued GC, w/ low risk of flare. BUT D/Cs were SLOW w/ only 9.7%, 26.6%, 48.0% & 58.6% at 6 mos, 1, 2 & 3 yrs - median time to cessation = 27 mos https://t.co/h02aueYKwN
Links:
Dr. John Cush RheumNow ( View Tweet)