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Pain in Psoriatic Arthritis

Patricia Harkins, MD

The prioritisation of pain, and its evaluation, is important in those with psoriatic arthritis, when the already incredibly heterogenous nature of the condition can complicate assessment. Whilst we lean towards all pain in PsA being nociceptive in nature, evidence suggests that a significant proportion of patients with PsA also have nociplastic pain, characterised by fibromyalgia.

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Sleep asleep

Sleep Quality & Psoriatic Arthritis

Olga Petryna, MD

For people living with psoriatic arthritis (PsA), the comfort of a good night's sleep may feel out of reach for many.

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Best of

ACR Best Abstracts - Day 3

Jack Cush, MD

The last day was jammed with important reports and research including the late breaking abstracts. 



 

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The complexity of opioid use in spondyloarthritis

Robert Chao, MD

A few things we know about opioids: use is common; it’s not efficacious in the treatment of spondyloarthritis; and, there is an opioid epidemic and its users are stigmatized. Abstract 0402 is a retrospective study that looked at patients with psoriatic arthritis or ankylosing spondylitis in the FORWARD databank. It sheds new light and leaves us with some food for thought

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male female

Do different genders experience PsA differently?

Olga Petryna, MD

There has been a lot of talk lately about the difference in the way male and female PsA patients experience their disease.  Are the differences only cultural or are there important clinical differences in the disease presentation, organ involvement and complications that physicians should be aware of?   

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Vaccine Efficacy in Patients with Seronegative Spondyloarthritis

Catherine Sims, MD

Vaccine efficacy remains an important and highly discussed topic at this year’s annual meeting given the ongoing COVID-19 global health crisis, current influenza season, and recently published 2022 ACR guidelines for vaccinations in patients with rheumatic and musculoskeletal diseases.

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Are MDA criteria created equal in PsA? Dr. Rachel Tate ( @uptoTate ) reviews abstract #1496: Do Patients in MDA Report Low Disease Activity Regardless of Which of the MDA Criteria Are Met? Presented at #ACR22. https://t.co/H4wPHEV8D5 https://t.co/NqXYxXRNEX

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Dr. John Cush RheumNow ( View Tweet)
Differences in Presentation and Outcomes of Early vs Late Onset PsA Dr. Petryna ( @DrPetryna) discusses abstract 0377 presented at #ACR22. Abstract 0377: Differences in Early-onset vs. Late-onset PsA: Data from the RESPONDIA and REGISPONSER Studies https://t.co/Bw3RHp3lSR https://t.co/Yva84Iw8hk

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Dr. John Cush RheumNow ( View Tweet)
Patient Reported Outcomes in PsA Using Novel IL 17A Inhibitor Dr. Sims ( @DrCassySims) discusses abstract 0199 presented at #ACR22. https://t.co/L14WoimRE6 https://t.co/LhgyE1LwGa

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Dr. John Cush RheumNow ( View Tweet)
Curtis et al. Primary non-adherence to csDMARDs and b/tsDMARDs in RA/PsA/SpA. Medicare and commerically-insured patients. 20-44%! of new prescriptions not filled by 6 months. Higher for csDMARDs than b/tsDMARDs @RheumNow #ACR22 Abstr#2199 https://t.co/Pwg6GKu7Gg https://t.co/wPF0pu1UDa

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Richard Conway RichardPAConway ( View Tweet)
Pain in #psoriaticarthritis might not be all inflammatory.. In this study presented by Dr F Sunzini: 👉PsA pts w/⬆️FM scores had⬆️functional brain connectivity bet mid-post IC & thalamus, phgyrus & PFC ..so consider nociplastic pain too & adjust mgt #ACR22 @RheumNow ABST#2256 https://t.co/suCAvx0pD5
sheila RHEUMarampa ( View Tweet)
BE OPTIMAL Study - Bimekizumab (IL-17A and IL-17F inhibitor) for treatment of PsA. Similar ACR 50 (~50%) response rates of Bimekizumab, adalimumab, and placebo (switched to BKZ at wk 16). ~60% PASI100 in BKZ #ACRBest Abs#L02 @RheumNow #ACR22 https://t.co/W2B2kyju9F
Robert B Chao, MD doctorRBC ( View Tweet)
Ritchlin et al. Bimekizumab in bDMARD naive PsA. 52 week results. Not surprisingly, week 16 outcomes sustained. No joint difference to ADA, skin slightly better @RheumNow #ACR22 Abstr#L02 https://t.co/RjCV8Hb3HR https://t.co/a0NQFyFZlt

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Richard Conway RichardPAConway ( View Tweet)
A new murine model to study Pso and PsA! Immunodeficient mice NSG-SGM3 🐁 injected w/ serum & PBMCs from Pso and/or PsA pts = pro & arthritis (same phenotype than pts) Mice skin & synovia >effector memory CD8 T cell & < naïve https://t.co/cxSvEZC9Ly Abs#L04 #ACR22 @Rheumnow https://t.co/hfbtSsP3f8

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Aurelie Najm AurelieRheumo ( View Tweet)
#L02 #acr22 @rheumnow Bimekizumab ph3 in PsA: meaningful clinical improvement, improved mTSS, no new safety signals. Wk 52 ACR50: 53.0% PBO/BKZ, 54.5% BKZ, 50.0% ADA; MDA 53.7% PBO/BKZ, 55.0% BKZ, 52.9% ADA . mTSS change from baseline ≤0.5): 87.3% PBO/BKZ, 89.3% BKZ, 94.1% ADA https://t.co/NYRrPUBjt1
Olga Petryna DrPetryna ( View Tweet)
BE OPTIMAL: BKZ in PsA Phase 3 RCT Data at 52 wks 700+ completed study ACR50: 53% PBO/BKZ, 54% BKZ, 50% ADA PASI 100 65% PBO/BKZ, 61% BKZ, 48% ADA No Rx progression 87% PBO/BKZ, 89% BKZ, 94% ADA Candida infections 7% BKZ, 0.7% ADA https://t.co/MMjN1Aa3qf Abs#L02 #ACR22 @Rheumnow https://t.co/keF0QOZMwA

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Aurelie Najm AurelieRheumo ( View Tweet)
Get the skinny on Bimmy! Gotta learn this name #Bimekizumab in bio naive PsA N=852 Bimmy=IL17 A & F inhibitor Great data on skin & joints. Where will it fit in as we have other IL17Ai’s is IL17F giving added value? #ACR22 #ACRBest @RheumNow https://t.co/wNAzTaLhsM
Janet Pope Janetbirdope ( View Tweet)
Does tofacitinib work better in patients with PsA and AS who smoke? Abstract #1036 #ACR22 @RheumNow 🚬519 ever smokers 🚭767 never smokers 💉In PsA only, TOF efficacy was greater in ever smokers vs. PBO ✋Overall, efficacy was generally comparable in ever v. never 🚬

Catherine Sims, MD DrCassySims ( View Tweet)

Here's the 1 year model #ACR22 @RheumNow https://t.co/VhEuJMMyIt
Richard Conway RichardPAConway ( View Tweet)
Eder et al. New PRESTO prediction model for PsA development in PsO. 1 year and 5 year models presented @RheumNow #ACR22 Abstr#1612 https://t.co/xMMVaIGnN5 https://t.co/RlJ3ZlEeDE

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Richard Conway RichardPAConway ( View Tweet)
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