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Longitudinal UK SLE inception cohort 273 pts found:
👉⬆️damage in 1st 3 yrs b/f stabilizing at lower rate
👉mortality uncommon in 1st 12 yrs, but can occur w/in 5 yrs of Dx.
👉unexpected⬆️mortality in Caucasians
38% deaths IHD, 23% infx
Abst#0111 #EULAR2021 @rheumnow @Lupusdoc https://t.co/wUwWaB4V2R
k dao KDAO2011 ( View Tweet)
Can you predict flares in SLE pts who achieved LLDAS? Retrospec cohort study from Portugal over 3 years of 292 pts who were in LLDAS, 31% flared. Flares seen more in: 👉pts who require ongoing Rx w/ immmunosuppr, GCs 👉pt w/+RNP Abst#0105 #EULAR2021 @RheumNow https://t.co/xfBqGh4pPP
k dao KDAO2011 ( View Tweet)
C3 and C4⬆️in SLE pregnancy like they would in pregnancies w/o SLE!
French GR2 prospective study of 290 SLE pregnancies quantifies mean C3 value⬆️by 28%, C4⬆️by 11% from 1st ➡️3rd trimester. Remember this when assessing disease activity. #EULAR2021 Abstr #0103 @rheumnow https://t.co/TXjO4mjNJE
k dao KDAO2011 ( View Tweet)
Definition of LLDAS: "A state assc w/low likelihood of adverse outcome, considering disease activity and medication safety; it must be favorable, deployable, feasible, and attainable," - Dr. E Morand #EULAR2021 @RheumNow https://t.co/oMMU3AjhmX
k dao KDAO2011 ( View Tweet)
Quick update from #EULAR2021! Patient reported outcomes are important but how can we use them clinically in a meaningful way. Some key SpA/PsA findings from the experts at ASRI and the CorEvitas registry @rheumnow https://t.co/irxQs7Yzrx
Dr. Rachel Tate uptoTate ( View Tweet)
Dr. G Robinson Abstr#OP0013 on sex link b/t autoimmune & CV risk
👉Hormones drive funx change in Treg transciptome
👉anti-inflamm Tregs⬆️in males
👉Tregs are more suppressive in males
👉Treg transciptome profile altered b/t males & females in autoimmunity #EULAR2021 @rheumnow https://t.co/p4Awfu2hiK
k dao KDAO2011 ( View Tweet)
In DESIR AxSpA cohort: only 25% of patients achieved remission at 5 year follow up!!! Lower SES and ^ weight were negative factors in remission. Abstract #OP0052 #EULAR2021 @RheumNow https://t.co/X4wN1wIGfX https://t.co/DKBIXmEmki
Dr. Rachel Tate uptoTate ( View Tweet)
Female AxSpA pts report worse PROs but have better spinal mobility vs male AxSpA pts. Dz activity pattern similar in 4/6 BASDAI components regardless of gender. Females reports ^ fatigue, males report ^ spinal pain. Abstract# OP0051 #EULAR2021 @RheumNow https://t.co/U8T8JEWwCp https://t.co/yNP6PuA8PD
Dr. Rachel Tate uptoTate ( View Tweet)
ProDERM study (95 pts): RBPCT phase III IVIG 10% is effective in dermatomyositis (2 g/kg over 2-5 days q4 weeks. (common AEs: HA, fever, nausea most common AEs, rare SAE include thrombosis, LoC, hypoesthesia). Dr. R Aggarwal Abstr#OP008 #EULAR2021 @RheumNow https://t.co/ScTdUySxOl
k dao KDAO2011 ( View Tweet)
Put out cigarettes around others!
👉passive smoking in childhood & adulthood⬆️RA risk
👉RA occurs earlier for passive smoking in childhood
👉passive smoking can cause citrullination in genetically proned subjects b/f 1st Sx's
Dr. Y Nguyen Abstr#OP0012 #EULAR2021 @rheumnow https://t.co/ZoIumNQQAf
k dao KDAO2011 ( View Tweet)
Flow&digital cytometry in early Rx-naive RA disting immunophenotypes in periph blood & dz tissue. Dr. F Rivellese Abst#OP0011
👉B cells invers correl w/inflamm'n & dz activity
👉Tph cells are potential markers of synov inflamm'n & predict clinical outcomes
#EULAR2021 @rheumnow https://t.co/5GLx0espBX
k dao KDAO2011 ( View Tweet)
Plenary abstract #OP0013. In autoimmunity: Male lipoprotein profile: ^ CV risk, but had ^ anti-inflammatory features vs females, 2/2 sex hormones. Possible pathway to dx and tx of inflammatory disease in the future? #EULAR2021 @RheumNow @eular_org https://t.co/Z2KmEQftve
Dr. Rachel Tate uptoTate ( View Tweet)
Differences in PROs found in CORRONA(now CorEvitas) PsA/SpA registry Ax-PsA and AxSpA patients. Can we better use PROs for disease characterization/differentiation? Abstract #OP0049 #EULAR2021 @RheumNow https://t.co/uHW2FQe0A5 https://t.co/HuPPUTAC9Z
Dr. Rachel Tate uptoTate ( View Tweet)
What to tell pts with IA about their risk with #COVID19? Depends. Age & major comorbidities (CAD, COPD, HTN, DM, ⬆️ BMI, steroids) are impt. IA pts have ⬆️ ICU admissions & intubation so risk is ⬆️ but pts with IA were older with ⬆️comorbidities vs controls @RheumNow #EULAR2021
Janet Pope Janetbirdope ( View Tweet)
What to tell IA pts re response to #CovidVaccine? Global Rheum Alliance showed worse outcomes if on #Rituximab for #SARS_CoV_2 infection OP0006 Good immunity was found with Pfizer vaccine against spike protein but MTX, steroids, MMF blunt response LB003 #EULAR2021 @RheumNow
Janet Pope Janetbirdope ( View Tweet)
Plenary abstract #OP0010: Fecal microbiota transplant (FMT) found to be inferior to sham in treating active peripheral PsA. No SAEs in patients treated with FMT. @RheumNow #EULAR2021 https://t.co/a5HgrJ4y1C https://t.co/Jk9FQZdn4B
Dr. Rachel Tate uptoTate ( View Tweet)
Does Fecal transplant work to treat PsA?
per FLORA trial: No benefits from fecal microbiotia transplantation vs sham in PsA w/ active dz despite MTX (limited by small size, high placebo response) - Dr. M Kragsnaes Abstr#OP0010 #EULAR2021 @rheumnow https://t.co/I7PsWgK9uA https://t.co/OKC4QcH8Nq
k dao KDAO2011 ( View Tweet)
Wow!
Video vaccine education message directly sent to patient cell phones by SMS is low cost, simple and effective to educate rheum patients about #COVIDvaccine. 76.6% of pts were more likely to take the vaccine.
Abst#OP0009-PARE #EULAR2021 @rheumnow Dr. L Rajagopala https://t.co/OLBOSrmHVR
k dao KDAO2011 ( View Tweet)
#Dementia is ⬇️ing in #RheumatoidArthritis btwn 1980s & now despite theory of NSAIDs being protective for cognitive impairment & they have ⬇️ed over time vs matched pop’n. Maybe due to biological or other factors Olmsted county pop study @RheumNow @eular_org #EULAR2021 OP0216 https://t.co/qTWDtSfPt0
Janet Pope Janetbirdope ( View Tweet)
Yes more lab abnormalities in #Upadactinib vs #Adalimumab in RA RCTs including cytopenias, transaminitis but not creatinine @RheumNow @eular_org #EULAR2021 but no diff in treatmt emergent Adverse events abst OP0128 Yes do labs when on #Upadacitinib https://t.co/5ypKGxuE3U https://t.co/XRjr0gDnIT
Janet Pope Janetbirdope ( View Tweet)