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Mitochondria as Master Regulators of Inflammation

Jack Cush, MD Jul 25, 2022

Mitochondrial constituents and metabolic products may give rise to immune activation; this is especially true for mitochondrial DNA, which can function as damage-associated molecular patterns (DAMPs) leading to inflammasome activation.

Tonight! Sign up for Tuesday Night Rheumatology at 7pm! https://t.co/bnEXGUeeyx https://t.co/A4MaXWfhRO

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Transcription factor ETS-related gene (ERG) is an orchestrator of lung capillary homeostasis & repair. Dysfunctional ERG signaling drives pulmonary vascular aging and persistent fibrosis https://t.co/TMFBa74ob7 https://t.co/n60DwGaa74

https://go.nature.com/3cJjVT7

Heterozygous deficiency of Aggrecan (proteoglycan w/in cartilage) gene: manifests as inherited short stature, early-onset osteoarthritis, degenerative disc disease, osteochondritis dissecans, increasing joint pathology over time https://t.co/4iQdNL79oB https://t.co/qxStgE641v https://t.co/EHPJuIeQGt

Treatment Options for Still's Disease Gotta know if you're treating “systemic” or “articular” (arthritis) Still’s disease. Most Still’s patients have a dominance of one or the other. With certainty, the right therapy for the right symptoms can be chosen. https://t.co/fPBk6PdCaD https://t.co/u3RfWsnyv6

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Review of Clinical Trial measures in systemic sclerosis: -RCTs focus on skin dz, ILD or Pulm HTN using mod. Rodnan skin (MRSS), 6-min walk -FVC is surrogate measure for SSc-ILD - Composites: CRISS, the EUSTAR-AI -Future: Skin mRNA biomarkersTHBS1 and COMP https://t.co/2KD892VIUy https://t.co/9giddEl9I4

https://go.nature.com/3S0r69j

11.5% of Crohns pts have TNFi use contraindications (either MS, CHF, neoplasia, infx risk, TNFi AE, comorbidities, SLE. Alternatively GI survey respondents use ustekinumab (76%), vedolizumab (249%), or tofacitinib (0.5%) https://t.co/6ApUz93iS0 https://t.co/PTmnsTd2Wh

https://bit.ly/3RTeYHg

Novel autoinflammatory disease with an ALPK1 gain-of-function mutation: ▶️ R etinal dystrophy ▶️ O ptic nerve oedema ▶️ S plenomegaly ▶️ A nhidrosis ▶️ H eadache https://t.co/9GbjZLMFCo https://t.co/Bh0MkYmrDA

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🌏 Today is World Sjögren's Day!🌍 🩺 Sjögren's is not Just Dry eyes👁️ and Dry Mouth👅👄 - there's much more to it There's still a lot about this 'invisible' #Autoimmune Disorder, we don't know Clinical Features and Pathogenesis #LetstalkaboutSjögrens #MedTwitter #RheumTwitter https://t.co/t9toed8MG7

Anyone who thinks BA.5 is just another variant isn't paying attention >200,000 new cases yesterday. Vertical. https://t.co/x7wziHMZ9K

Successful use of ixekizumab for glucocorticoid-free remission maintenance in giant cell arteritis https://t.co/6f9yZwUFPb Another IL17 looking promising in GCA!

Successful use of ixekizumab for glucocorticoid-free remission maintenance in g…

213 #SLE pts were screened for Cryoglobulinemia (2013 -2017); CG is frequent in SLE (66%), but mostly asymptomatic. Mean levels 40mg/L (0-228). Cryo Vasculitis in 15% w/ purpura, ulcers, digit ischemia, arthritis, GN (5%) or CNS (19%) https://t.co/jRVXCj4MlV https://t.co/gamOOwkJ5R

https://bit.ly/3zCKWRb

Overdose deaths increased to 107 000 deaths in US in 2021, with significant racial disparity. Higher overdose rates seen in American Indian, Alaska Natives and Blacks. WORSE during COVID - 2020, overdose rates were 7 times higher in Blacks than Whites https://t.co/PMRo9gbzZl https://t.co/CgxgemyEA7

https://bit.ly/3oomv39

JAMA patient (resource) handout on Lumbar Spinal Stenosis! https://t.co/fl5K5Ve6fY https://t.co/aLHs6sKE1o

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French study from 362 septic arthritis pts over 2 yrs., mean age was 64yrs, w/ high Charlson comorbidity index 3.5. Most common was Knee (39%), Staphylococcus (51%), Abx used 47d, surgery in 48%; 28% serious complications & 9.2% died https://t.co/PdddHsagFg https://t.co/3oHbW0tAjU

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Spinal Findings on MRI May Not Signify SpA Research indicates that rheumatologists should be cautious about diagnosing SpA on the basis of imaging alone. https://t.co/Z4gox4cx9N https://t.co/PI9BCty8Bx

https://bit.ly/3veQU7Z

Leflunomide versus azathioprine in lupus nephritis? Study of 215 bx proven LN given either LEF or AZA - Renal flares were equal (15.7% v 17.8%), as was time to flare (16 mo vs AZA 14 mo); 24-hr proteinuria, creatinine, C3 and C4 improved similarly. https://t.co/2TWmweS2wy https://t.co/0YzlU4vfXP

https://bit.ly/3PMedOo

Sometimes the journey impacts as much as the destination. TREAT-EARLIER now @TheLancet: pre-RA (CSA+MRI) DBRCT: po MTX for 1y (+im mpred120x1) vs placebo eventual RA same but persistent benefit at 2y (1y post-MTX cessation): function, Sx, presenteeism, MRI a short thread🧵1/7 https://t.co/64b7us6hvS

https://twitter.com/TheLancetRheum/status/1550479166704852992

During 2021-22, there was 387,112 deaths due to pneumonia, influenza, or COVID-19. At least 72% were dut to COVID-19 and 0.6% was due to influenza https://t.co/0ljpXJt0yr https://t.co/1Sp4RULVAY

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Mitochondria as Master Regulators of Inflammation

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