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Dr. Jack Cush reviews the new studies and drug approvals and new insights into febrile disorders from the past week on RheumNow.com
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Antimalaria (AM) therapy is a cornerstone to the management of systemic lupus erythematosus (SLE), yet a recent study suggests that slowly tapering AM yields a lower rate of SLE flares.
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What is the classic 'triad' of Still's disease? Does it affect males and females equally? What are typical lab findings? Which drugs are effective at treating Still's, and as importantly, which ones are not? What about complications? Read on for these and other FAQs regarding Still's disease.
Dr. John Cush
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Viscosupplementation Ineffective in kOA
The BMJ has published the results of a metanalysis showing strong conclusive evidence that viscosupplementation in kOA has minimal effects on pain/reveals strong of an increased risk of adverse events.
https://t.co/hOy0JczC4I https://t.co/Hc2rwbZS3q
Dr. John Cush
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Immunoprofiling of synovial CD4+ T cell subsets shows that ACPA+ pts differ from ACPA- RA by having high expression of adhesion G-protein coupled receptor 56 (GPR56) on synovial CXCL13high TPH CD4+ T cells expressing LAG-3 https://t.co/LQ77CIdh9o https://t.co/chfmLfIqeF
Dr. John Cush
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Ustekinumab (IL-12/23i) phase 2 study was successful in #SLE; but the phase 3 LOTUS study of 512 pts, UST was NOT superior to PBO (SRI-4 44% v 56%) at 1 year. Study was halted for lack of efficacy (but no safety concerns). https://t.co/X5CKYVFxg5 https://t.co/6HVw6AMJPL
Dr. John Cush
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QD Clinic - Stills (or Not) with Hives
What do you think? 40 yr. woman with fevers, hives, and LFTs.
https://t.co/IZNnWzerOL https://t.co/sUGPuy2tKC
Dr. John Cush
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mitochondrial DNA can drive SLE by PMN uptake, NETs, activation of STING & type-I IFN. Maybe same for Autoinflammatory responses were oxidized mtDNA provokes cGAS-STING, binding cytosolic NLRP3, triggering inflammasome activity. https://t.co/sTDTkoMQX2 https://t.co/wXhVzzIFRC
Dr. John Cush
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Steroid Injection for Chronic Achilles Tendinopathy
Adding a corticosteroid shot to exercise therapy significantly improved symptoms of chronic Achilles tendinopathy, a 100-person randomized trial found.
https://t.co/sdYmsVpBsU https://t.co/r9zFVUmE88
Dr. John Cush
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Watch: What's new in sarcoidosis?
https://t.co/GnU1FDnUhn https://t.co/H1omKPtQmn
Dr. John Cush
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NEJM Case - 17-Year-Old Girl with Fever and Cough and B/L lower lobe infiltrates. 3 wk hx started w/ conjunctivitis, SOB, Cough fever myalgia & knee pain. No rash. T 38.5°C, W 11.5, H/H 6.9/21, P526k, CRP 77mg/L, UA 2+ protein, neg COVID tests. https://t.co/VOiW7DIdBR https://t.co/1GWA2gAgeK
Dr. John Cush
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1 yr success of knee arthroplasty was drawn frm 20 studies (11 317 pts, 37 factors) suggests higher BMI was correlated w/ worse physical function. Physical function & OA severity assoc. w/ better function post-TKA https://t.co/jtDCeprUhd https://t.co/Tflw8VO5Kw
Dr. John Cush
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Metanalysis (48 pubs, 145 refract pts) of JAK inhibitors in myositis (DM, JDM) shows significant improvement in skin lesions, muscle weakness, and ILD. https://t.co/EUOB8XUCht https://t.co/SYeYwooUkW
Dr. John Cush
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Worldwide metanalysis of FUO shows most common infections to be Mycobacterium tuberculosis (34%), brucellosis (10%), endocarditis (7.5%), abscesses (7%), herpesvirus (CMV,EBV 7%), pneumonia (6%), URI (6%), enteric fever (5%) https://t.co/RPMb1kYEI9 https://t.co/E0lrizOUkF
Andy Tran
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What's going on here? https://t.co/3jwbRazJhc
RCHPediatrics
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When to think beyond infection in recurrent fever??Join us to learn a clear approach to fever and auto inflammatory disorders from expert faculty @bhat_chandrika at #cusp @rakshay_shetty @PedRheum @PeriodicFeverUK @LatikaGupta_ @DrPujaMehta1 https://t.co/roMVbBDaNK
Hector Chinoy
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@DrPujaMehta1 @leticiakawano @docrota @DrJoPorter @drharsha_gunawa @best_rheum @jeffsparks @AshimaMakol @pedrommcmachado @KaminskiMed @KerriBerriKerri @DrPeter_George @scott_matson @LatikaGupta_ What about this one https://t.co/E6oMCFlplt
Puja Mehta 🧩
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Pleased to share our review
Management of #Myositis #ILD practical guide for clinicians
#Teamwork ✍️💪
@docrota 🇺🇸 🖐️
@DrJoPorter 🫁
@drharsha_gunawa 🖐️
OpenAccess😃
https://t.co/fhCHvzXdVP
3 clinico-serological phenotypes
1⃣ anti-synthetase
2⃣ anti-MDA5
3⃣ anti-PM-Scl
/1 https://t.co/B1Qh0drSbg
Indiana University Infectious Diseases Fellowship
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#idboardreview #meded #idmeded #IDtwitter #dermtwitter #MedTwitter Infectious differential diagnosis of rash involving palms & soles https://t.co/xXK4nYwEoi
Mithu Maheswaranathan, MD
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🆕🌟CDC Guidance on COVID-19 Vaccines for Children <18 yrs who are Immunocompromised 👦👧🏾💉⬇️
Thank you Dr. Rebecca Sadun for reviewing!
#PedsTwitter #PedsRheum #Pediatrics https://t.co/eeuRKflhSO
