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Lower Rates of Serious Infection with Ustekinumab in Psoriatic Disease

d MedPage Today

Patients with psoriasis or psoriatic arthritis who were being treated with ustekinumab (Stelara) had lower rates of serious hospitalized infections than patients receiving other biologics or small molecule therapies, a study utilizing data from two commercial claims databases found.

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Tocilizumab Risk of Diverticulitis and GI Perforation

d Jack Cush, MD

A French registry analysis compared the risk of diverticulitis and gastrointestinal perforation (GIP) in rheumatoid arthritis (RA) patients treated with biologics and found a greater risk of both in patients receiving tocilizumab (TCZ) compared with those on rituximab (RTX) or abatacept (ABA

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TAA, TAR, Ankle, replacement

Total Ankle Arthroplasty vs. Arthodeisis?

d Jack Cush, MD

 The Journal of Bone & Joint Surgery reports the findings of a 4-year trial comparing outcomes of total ankle arthroplasty (TAA) versus ankle arthrodesis (AA) in patients with severe ankle arthritis; finding that while both groups improved, TAA was associated with less pain and better function after 4 years.

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Checkpoint Inhibitor Safety in Melanoma Patients with Autoimmune Disease

d Jack Cush, MD

Immune checkpoint inhibitors (ICI) are well known to cause immune-related adverse events (irAEs). A study from the Dutch Melanoma Treatment Registry shows that the use of checkpoint inhibitors for advanced melanoma in AID (autoimmune disease) patients did not increase the risk of irAEs, except for those with preexisting IBD.

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OA, erosive, inflammatory, DIP

Severity Associated with Erosive Hand Osteoarthritis

d Jack Cush, MD

Erosive hand osteoarthritis (EHOA) was studied as part of the Osteoarthritis Initiative, and shown to increase with advanced age and female sex, with developmental findings to suggest that EHOA as a disorder of skeletal frailty.

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There is no downside to promoting oral health in our patients. Even without RCTs, knowing that there are possible links between oral health and RA outcomes is enough reason to have discussions with our patients with periodontal disease, and encourage treatment #EULARJC

Jon T Giles JonTGiles1 ( View Tweet)

If any rheums out there have not watched the vaccine town hall by @ACRheum I highly recommend it. A master class on vaccine counseling by @gradydoctor ! Thank you! Thanks @IreneBlancoMD and @DrDavidKarp https://t.co/4ofQVkjKYz via @YouTube

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Jilaine Bolek Berquist BolekBerqui ( View Tweet)

Metanalysis (11 RCTs, 19 registries) of Pulm arterial HTN assoc. w/ CTD (w/ 1,267 & 4,008 CTD-PAH pts), showed Investigational Rxs reduced morbidity/mortality by 36%. CTD-PAH survival was lower (62 vs 72%) @3yrs, but improved after 2010 (73 vs 65%) https://t.co/0BkO70AQfi

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Dr. John Cush RheumNow ( View Tweet)

Textbooks say fever is common in lupus ("36%–86%") BUT IT IS NOT! Lupus is cause of FUO in 5%; Fever is seen in a minority of SLE onsets; Fever occurs w/ SLE complications - vasculitis, pneumonitis/serositis/alveolar hem, CNS, & INFECTION! https://t.co/KvZeo6Q1WY

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Dr. John Cush RheumNow ( View Tweet)

"Evidenced based medicine is not enough; you can perfectly execute the wrong decision." - Dr. Dino Kazi on the important role of clinical reasoning in patient care #UTSWRheumGrandRounds

UTSWRheum UTSWRheum ( View Tweet)

Great UTSW Rheum Grand Rounds by Dr. Dino Kazi on "Clinical Reasoning". Graphic shows stages of learning & Dunning Kruger effect describing gap of what we dont know but think we do know @UTSWRheum @UTSWIMchief @DinoKazi https://t.co/bFiWOJ2IXz
Dr. John Cush RheumNow ( View Tweet)
Checkpoint Inhibitor Safety in Melanoma Patients with AID A study from the DMT shows that the use of checkpoint inhibitors for advanced melanoma in AID patients didn't increase the risk of irAEs, except for those with preexisting IBD. https://t.co/VFzBOlc0wc https://t.co/0zfr8YFmZr

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Dr. John Cush RheumNow ( View Tweet)
Good review of the epidemiology of Psoriatic disease - Psoriatic arthritis (PsA) is a chronic, progressive musculoskeletal disease that affects 0.1%–1% of the general population and ~20% of patients with psoriasis. Might wt loss be a prevention? https://t.co/kvoNqMMr7r

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Dr. John Cush RheumNow ( View Tweet)

Rituximab Tops Mycophenolate Mofetil for Pemphigus Vulgaris. One year study of 135 moderate-to-severe pemphigus patients saw complete remission in 40% of RTX vs 10% of MMF patients. https://t.co/yAauFRjHCe

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Dr. John Cush RheumNow ( View Tweet)

JAK inhibitor helping vitiligo? Results from phase 3 TRuE-V trial ruxolitinib cream in adolescent/adult vitiligo pts - showed significantly more RUX pts with 75% improvement in facial vitiligo area scoring index (F-VASI75) compared to control at Week 24 https://t.co/q98CBjfdQi

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Dr. John Cush RheumNow ( View Tweet)

RNL 2021: Best of times, worst of times (Keynote): Dr. Iain McInnes Dr. Iain McInnes presents his keynote lecture, Best of Times, Worst of Times..., at RheumNow Live 2021. https://t.co/v3hOYuJZad

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Dr. John Cush RheumNow ( View Tweet)

Rheumatologists--submit a question or case for Jack Cush and we may use it on an upcoming podcast. https://t.co/wzNmOzH4VE https://t.co/pWbUcmLu2O

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Dr. John Cush RheumNow ( View Tweet)
Dr. Jack Cush - Hemoptysis in Lupus https://t.co/SjBazKiTW8 #LupusAwarenessMonth https://t.co/6z2R456Clm

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Dr. John Cush RheumNow ( View Tweet)
Did you miss #RNL2021? We'll be sharing them on the site. RNL 2021: Interstitial Lung Disease in RA - Dr. Jeff Sparks ( @jeffsparks ) https://t.co/0Z5PsWyMFH

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Dr. John Cush RheumNow ( View Tweet)

International survey by the World Lupus Federation of 6,100 lupus pts from over 85 countries shows 50% reporting decreased access to lupus healthcare; including /rheumatologist 36%, medical tests 29%, infusions 24%, meds 17% https://t.co/5tlbiP65gf

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Dr. John Cush RheumNow ( View Tweet)

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