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Potent Topical Corticosteroids and the Risk of Osteoporotic Fractures

d Jack Cush, MD

JAMA Dermatology has published a Danish national cohort study showing that potent topical corticosteroid use was associated with an increased risk of osteoporosis and major osteoporotic fractures with a dose-response association for cumulative use.

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MDA-5 Antibodies and Juvenile Dermatomyositis

d Jack Cush, MD

A multicentre, retrospective study examined MSA profiles (by immunoprecipitation) from 96 juvenile idiopathic inflammatory myopathies (JIIM) at nine pediatric rheumatology centres in Japan. MSA were found in 85 of 96 cases with over 90% of patients having one of the following three MSA

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Enthesitis Responses to Secukinumab in Spondylitis Patients

d Jack Cush, MD

Schett and colleagues studies the secukinumab (an IL-17 inhibitor) response in patients from 3 clinical trials with enthesitis and ankylosing spondylitis (AS) and demonstrated consistent efficacy with improved enthesitis scores at both peripheral and axial sites.

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Rheumatic Patients Are at Risk for COVID Death

d MedPage Today

Patients with rheumatic diseases who developed COVID-19 were at increased likelihood of death, with risk factors similar to those seen in the general population but also because of factors specific to their underlying disease and its treatment, analysis of data from an international registry foun

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Great full read NEJM review of Extrahepatic manifestations of Chronic HCV Infection; 1) mixed cryo vasculitis; 2)20-30% w/ HCV related Sicca (w/ SSA, SSB); 3) fatigue & FM; 4) AutoAbs: 70% RF+, <40% ANA+, 15% ACL Abs, 7% smooth muscle Abs https://t.co/YrIJbs8P8k

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Charcot (neuropathic) arthritis: often manifests as exaggerated bony hypertrophy w/o joint pain. Common causes(sites): diabetes (TMT ankle), tabes dorsalis/syphilis (hip or knee), syringomyelia (Shoulders, elbows) . Also CPPD, steroids, alcohol, amyloid https://t.co/SrYYrVjSq3

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BC Canada population study shows newly diagnosed #SLE patients (n=5,169) have a higher rate of 1st serious/sever infections (1.8-fold), and more total severe infections (2.1-fold) and infection-related mortality (1.6-fold) vs general population. https://t.co/acDk0WYSby

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Rinvoq (upadacitinib) was slated for a psoriatic arthritis indication this month, but now that has been pushed back ~90days, pending further FDA review of the benefit-risk profile for upadacitinib in psoriatic arthritis https://t.co/FeBOrNIbTo

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Have you listened to this week's podcast? We answer listener questions. https://t.co/LXW8uyFGNP

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News Feature: Comparison of Three Coronavirus Vaccines https://t.co/omxsA8W3nQ https://t.co/s7dc9NwMQo

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News Feature: Rheumatic Patients Are at Risk for COVID Death https://t.co/bhJG1vuVA4 https://t.co/VEN3nwSOPB

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REMDACTA trial of Actemra plus remdesivir failed to meet its primary endpoint of improved time to hospital discharge for patients with severe COVID-19 pneumonia (nor its key secondary endpoints) compared to remdesivir alone https://t.co/OyqpnwUVXU

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4 Days! RheumNow Live is a powerful, interactive meeting delivered by researchers, educators, & clinicians. Sign up to attend virtually or in-person today. CME credits available. https://t.co/LJ3qClHTKh

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β-blockers may lower risk of knee OA and knee pain. Matched cohort study of 100K pts from UK registry shows β-blocker use associated with 10-12% lower risk of knee OA, knee pain & hip pain consultations, moreso w/ Propranolol and atenolol (9-22%) https://t.co/38RoeP1Pmw

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2020 Year in Review - Top Publications in SpA and Still’s Disease Sponsored by Novartis Medical Affairs Listen to medical experts discuss their latest insights in spondyloarthritis and Still’s disease. View Now: https://t.co/rxTAwQNalx https://t.co/6vAAs2qgA9

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News Feature: Low Anaphylaxis Risk with COVID mRNA Vaccines JAMA reports a safety survey of hospital employees showing that the risk of anaphylaxis from mRNA vaccines is 2.47 per 10,000 individuals. https://t.co/hN7UWNasQo https://t.co/0UhOZuGze1

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Listen to last weeks QD Clinics Podcasts (Mar 12)-Ms. RA, Notalgia & Anti-Intraarticular. QD147 - Combination Biologics QD146 - Anti-Intraarticular QD145 - Notalgia? QD144 - Ms. RA QD143 - Blinded by Noncompliance https://t.co/loSC6WNneR https://t.co/GxLCGptB4S

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French review of 41 TRAPS pts w/ amyloidosis AA. AA dx preceded TRAPS in 96% of cases, 47% needed renal replacement therapy and 14% died at 23 most F/U. 19 pts took biologics, 10 improved, 7 stabilized, 4 worsened. AA pts should be screened for TRAPS https://t.co/tONNSRCoOU

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COVID Vaccine Rebuttals by Dr. Kathryn Dao ( @KDAO2011) Dr. Dao addresses the common vaccine concerns that have been posed to her and her rebuttals. https://t.co/f5gwBICEGy https://t.co/Nzm1HfY5GW

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Can you use Combination Biologics or JAKs + Biologics? https://t.co/TwnpkTMuu7 https://t.co/J98JD4I8Oh

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