All News
Conaghan shares unpublished data from PROMOTE study at #RNL2023
Early data shows MTX benefits pain in patients w/ OA, particularly more metabolically active.
Looking forward to more data on this - though many many many DMARD trials thus far have been disappointing in OA
@RheumNow https://t.co/Ieagp8mq31
Mar 18, 2023
30% rule!
Risk of RA development in Pre clinical RA patient in the next 3 to 5 years .
Kevin Deane #RNL2023 @RheumNow https://t.co/J6Polz70im
Mar 18, 2023
Dr Philip Conaghan at #RNL2023
X-rays are misleading in OA
OA is a CLINICAL disease
Radiographs do not help in diagnosis or monitoring
@RheumNow https://t.co/ZrAfPN02qi
Mar 18, 2023
#RNL2023 @RheumNow
There are a lot of RA Rx on market now - do we need more?
Dr. Brenner: YES
Stromal targets like LIF/LIFR, Notch3, cadherin-11 offer upstream benefits for our difficult to treat RA patients that don't respond to tradition cs/bDMARDs https://t.co/zJRRisGW9i
Mar 18, 2023
@RheumNow Live #RNL2023
Stanley Cohen, MD:
Use of JAK inhibitor in patients with known ASCVD: Number needed to harm 16
ASCVD is biggest risk factor for MACE events with JAKi https://t.co/gXNUOO8seG
Mar 18, 2023
Dr Brenner at #RNL2023
Excellent description on how fibroblasts are major producers of IL-6 producers
Clinically presents a target for blocking the fibroblasts, upstream the inflammatory cascade in RA
@RheumNow https://t.co/TserFZtvhV
Mar 18, 2023
JAKinib safety takeaways
- avoid in older population > 65 yo, malignancy, CV risk, VTE risk
- appropriate in younger pts without VTE/CVD risk factors
#RNL2023 @RheumNow https://t.co/5i1bRqqr7g
Mar 18, 2023
@RheumNow Live 2023 Starts Tomorrow!
Or does it start earlier?
Love that there is a pre-learn and pre-test to set the stage for #RNL2023
Excited for this talk by @anisha_dua on assessment for GCA/PMR
#RheumTwitter https://t.co/VcawlnaPFf
Mar 18, 2023
Faith and Miracle Larry
This week on the podcast, Dr. Jack Cush recalls what life was like early on during COVID, from March to June of 2020.
https://t.co/SfidfBF1En https://t.co/Jnv6moxYwQ
Links:
Mar 18, 2023
#RNL2023 @RheumNow
Dr. Stanley Cohen: possible adverse effects of JAKi
-Herpes zoster, other infections
-Malignancy
-Occasional cytopenias
-LFTs (with DMARDs)
-Incr Cr or CPK
-Acne
-Incr lipids
-GI perf
-VTE
Which do you counsel with your patients? https://t.co/AZDKShOPbU
Mar 18, 2023
Dr. Deanne reminds us that RA is worth preventing for many reasons. #RNL2023 @RheumNow https://t.co/va0RmdhUQR
Mar 18, 2023
Dr. Kevin Deane on preclinical-RA
Very complex history on development of RA with multiple phases before detectable RA shows up in your clinic.
#RNL2023 @RheumNow https://t.co/vzQFhik0aK
Mar 18, 2023
#RNL2023:
Kevin Deane: Anti-CCP positive leads to a 20-30% risk for articular clinical RA within 3-5 years
@RheumNow https://t.co/skp1K4r1hF
Mar 18, 2023
STOP-RA study on HCQ preventing RA...
HCQ did NOT prevent RA development in pre-RA pts
@RheumNow #RNL2023 https://t.co/Vv3szkqxWh
Mar 18, 2023
#RNL2023 @RheumNow
Kevin Deane presents his STOP RA Trial
HCQ is safe and easy - can you use it in pre-clinical RA to prevent disease?
NO EVIDENCE of decreased progression of RA in HCQ compared to placebo https://t.co/1OSVubd9rO
Mar 18, 2023
Treatment with MTX in early CCP+ RA thought to be effective in slowing disease however StopRA study did not show a difference between HCQ and PBO in patients. We need to know more about HCQ vs MTX in this space! #RNL2023 @RheumNow https://t.co/7asmvVfXiC
Mar 18, 2023
The holy grail. How to stop #rheumatoid #arthritis in at risk Pts. Who to treat, when to stop? Many RCTs but no home run-NNT is high. #MTX and a diff study #Abatacept that work while on Rx and #Rituximab, most don’t work esp after stopping Rx @kevindeane #RNL23 @RheumNow https://t.co/BkIxxS0ecn
Mar 18, 2023
Dr. Deane's current management of "pre-RA" pts
- carefully eval for synovitis
- lifestyle factors - stop smoking, diet, dental hygiene
- educate pt on ~30% risk
- annual in-person follow up
@RheumNow #RNL2023 https://t.co/Z0t0Yibyri
Mar 18, 2023
How do you prevent RA in at-risk patient?
Smoking cessation! Healthy weight and exercise! Diet! Periodontal health! 🚭🏋️🥕🦷
Education & follow-up!
Not robustly proven to prevent/delay RA, but may be more important than early DMARD intervention!
Kevin Deane, MD
#RNL2023 @RheumNow
Mar 18, 2023
Natural history of RA by Kevin Deane #RLN23 @RheumNow https://t.co/ab0cafDblz
Mar 18, 2023