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Systemic Sclerosis Insights (9.13.2024)
Dr. Jack Cush reviews the news and journal articles from this past week on RheumNow.com.
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Consumption of Alcohol and the Risk of Gout
Alcohol is a risk factor for gout and flares. While the inciting potential differs among alcohol types, are these differences sex specific?
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Higher Cancer Rates (8.16.2024)
Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow.com, noting his concerns about diet, cancer, ILD, death and dosing challenges.
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Depends on Where You’re Looking (8.9.2024)
Dr. Jack Cush reviews the news and journal reports from RheumNow.com this week.
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Have a a rheumatology question or case for Jack Cush? Record it here and we may feature it on an upcoming podcast. Tell us your name and where you practice rheumatology.
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Dr. John Cush RheumNow ( View Tweet)
NOR-Gout study shows Non-adherence to urate lowering therapy after 5 years is related to poor gout outcomes. 5-year Observational study of 163 patients showed overall good ULT adherence but nonadherent had more flares (33 vs 10%) & less at target (45 vs 87%)… https://t.co/xuIjBiuFHF https://t.co/fmqkCOYayP
Dr. John Cush RheumNow ( View Tweet)
Progression of Undifferentiated Arthritis to Inflammatory Arthritis
https://t.co/Ozr8jPnAcx https://t.co/Jctal4xznB
Dr. John Cush RheumNow ( View Tweet)
NOR-Gout study shows Non-adherence to urate lowering therapy after 5 years is related to poor gout outcomes. 5-year Observational study of 163 patients showed overall good ULT adherence but nonadherent had more flares (33 vs 10%) & less at target (45 vs 87%)… https://t.co/wHQIRbIoBu https://t.co/eBKL4uRfZc
Dr. John Cush RheumNow ( View Tweet)
ACR 2024 Abstracts are available.
Let the fun begin.....
https://t.co/uNLZBqjEX0
Search by term, title or abstract # here: https://t.co/Du1eN4gA9D
or
Search by sessions and topics here >> https://t.co/R7NH1jeHPj https://t.co/OCoTPr03nG
Links:
Dr. John Cush RheumNow ( View Tweet)
Systemic Sclerosis Insights (9.13.2024)
https://t.co/fRbKdSAqxG https://t.co/PMbYDXPHMd
Dr. John Cush RheumNow ( View Tweet)
French retrospective study of 181 hemodialysis pts (97 on urate Rx-90% allopurinol, 9% febuxostat). W/ ULT pts had significantly fewer agout flare (HR:0.42; CI 95: 0.25-0.71). Overall flares 35% (23% ULT vs 50% w/o ULT; p 0.0002) https://t.co/9hTgsR2Kx9 https://t.co/Bef0T1po2c
Dr. John Cush RheumNow ( View Tweet)
post hoc analysis of 4432 pt COLCORONA trial, showed colchicine had few drug interactions, none serious. The most common were interactions w/ rosuvastatin & atorvastatin (10-12% of all pts), that MAY nonsignificantly increase colchicine exposure https://t.co/W3JXne0ywH https://t.co/dNz6NVYjUW
Dr. John Cush RheumNow ( View Tweet)
Consumption of Alcohol and the Risk of Gout
Alcohol is a risk factor for gout and flares. While the inciting potential differs among alcohol types, are these differences sex specific?
https://t.co/CzE9ZSEN9f https://t.co/e4WBSBlNEo
Dr. John Cush RheumNow ( View Tweet)
AR882, a URAT1 inhibitor, was given FDA Fast Track designation for potential treatment of clinically visible tophi in patients with gout. In the US 13 mill have gout & 2 mill have visible tophi. AR882 was presented at EULAR24 https://t.co/StvD3iz9AD https://t.co/G9SzxJysSD https://t.co/KcUSPVb5pn
Links:
Dr. John Cush RheumNow ( View Tweet)
From 25K prediabetics, 1,521 had serial serum Uric acid measures. Predictors of increaed SU levels included Older age, male sex, greater BMI, and higher HbA1c. Those w/ a BMI ≥30 kg/m2 exhibited higher SU levels https://t.co/ztp8M781Dw https://t.co/PNaZxMIOlG
Dr. John Cush RheumNow ( View Tweet)
Metanalysis of 16 RCTs shows febuxostat reduces the risk of kidney events (RR = 0.56, 95% CI 0.37-0.84, p = 0.006) and a slower decline in eGFR (vs controls) https://t.co/9YAxTrHFVQ https://t.co/ZyRE7R6P4a
Dr. John Cush RheumNow ( View Tweet)
Rheums! Have a Rheumatology question or case for Jack Cush? Record it here and we'll feature it on an upcoming podcast. Tell us your name and where you practice rheumatology.
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Dr. John Cush RheumNow ( View Tweet)
EMR study looked at NIDDM & 4 indicators of #Obesity (waist circumference, waist/hip ratio, BMI, & visceral fat area -- 600 gout pts vs 9,935 controls shows all obesity measures signif incr odds of #Gout (OR 1.775, 1.691, 1.858, & 1.578, respectively) https://t.co/JJn5txgxiN https://t.co/tgnWWl9COe
Dr. John Cush RheumNow ( View Tweet)
Gout Forecast: 70% Increase by 2050
The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) of 2021 has forecasted prevalence of gout to increase by 70% by 2050.
https://t.co/7OSQXSBtUc https://t.co/p9hkO5xzAa
Dr. John Cush RheumNow ( View Tweet)
UK Biobank 11+ yr study of 5728 incident gout pts - light alcohol decreased in gout incidence among females (HR 0.78). Light red wine also reduced gout risk, whereas beer or cider, champagne or white wine, and spirits increased the gout risk at any dose. https://t.co/nP8vObFsOH https://t.co/DuXQMyeaE3
Dr. John Cush RheumNow ( View Tweet)
