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Delays in Diagnosis of Axial Spondyloarthritis

d Jack Cush, MD

The diagnosis of axial spondyloarthritis (and anklylosing spondylitis) (axSpA) is often delayed and usually not diagnosed by rheumatologists; a recent metanalysis shows that longer delays were attributable to lower education levels, younger age at onset and absence of extra-articular manifes

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Hydroxychloroquine Shortage During COVID-19

d Jack Cush, MD

According to a recent report in Annals of Rheumatic Disease, public enthusiasm for hydroxychloroquine (HCQ) created significant access issues for rheumatic patients in the early phases of the COVID-19 pandemic.

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Adipose Transplants as a New Regulator of Osteoarthritis

d Jack Cush, MD

A novel report from PNAS suggests that in osteoarthritis (OA), the damage is not entirely from body weight and mechanics, instead it may be from adipose tissue itself.

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Corticosteroid Use Hikes CV Risks in Rheumatic Patients

d Jack Cush, MD

UK Clinical Practice Research Datalink population study shows that patients with immune-mediated inflammatory diseases, such as RA, PMR, GCA and IBD, have an augmented risk of CV outcomes with glucocorticoid use; even lower doses had a near doubling of their underlying CVD risk.

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Telemedicine study on accuracy of Pt reported swelling predicting inflamm arthritis. 1637 pts w/ 13 wks of Sxs. 76% pts reported swelling, but only found by 41% of Rheums. Pt reporting sensitivity was was 87%, but specificity only 31%; PPV=46%, NPV=77% https://t.co/oV3p06BHRj

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New year, new QD Clinic- Clinic Emergencies. https://t.co/xyaVP8ZkmB https://t.co/QXTvp2mttV

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Study of 52 pts w/ pericardial dz in GCA (44) & PMR (8) finds only 46% were >70 yrs. Manifest as pericardial effusion (85%), was initial Sx in 37%. 69% were symptomatic & classic cranial Sxs present in only 40%. Tamponade more likely w/ PMR https://t.co/B5IxBT9OO7

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Adipose Transplants as a New Regulator of Osteoarthritis--A novel report from PNAS suggests that in osteoarthritis (OA), the damage is not entirely from body weight and mechanics, instead it may be from adipose tissue itself. Read more: https://t.co/0VpR4VPmBX https://t.co/jSALMKXrhB

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147 Obese patients (25 w/ gout, 55 w/ hyperuricemia) had bariatric surgery. 1 yr after sugery, pts lost mean 31 kg & decreased uric acid from 419 to 308 µmol 1–7 days postop and 328 @12 mos (P < 0.001). 40% of gout pts were at/below target. https://t.co/9e8zpWKHay

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Download your RheumaKnowledgy Card https://t.co/L7O0UFjEBV https://t.co/iFtVKERnjC

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Corticosteroid Use Hikes CV Risks in Rheumatic Patients--It is long known that high-dose steroids may increase the risk of cardiovascular disease (CVD), heart disease, stroke, or other vascular outcomes, but it is unknown what the risk is at lower doses. https://t.co/gkTLP3ceVD https://t.co/HMpvpham1q

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Medicare's 'Most Favored Nation' Drug-Pricing Rule in Limbo--The fate of the Trump administration's "most favored nation" (MFN) rule for bringing down prescription drug prices remains uncertain as President-elect Joe Biden prepares to assume office. https://t.co/3NnvyRiVDo https://t.co/gLSFERaNku

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SOBI announced Kineret is now FDA approved to treat DIRA (defic of IL-1 receptor antagonist), an ultra-rare, autoinflammatory Dz caused by a genetic mutation in the IL1RN gene,. Pts have life-threatening systemic inflammation with skin and bone involvement https://t.co/iccvWYJva9

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National Psoriasis Foundation Task Force updated their COVID-19 guidance statements. Including Guidance 4.6, stating PsA pts who receive a mRNA-COVID vaccine should continue their biologic or oral therapies as they manag of their psoriatic disease https://t.co/byujtDET33

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Retrospective study of 171 GCA patients found that 32% had aoritis (by Sxs or AI murmur); hese pts were 6 fold more likely to have subsequent Aortic complications (aortic aneurysms or dissection) https://t.co/zRVzmnU7JH

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After your 2 doses of COVID vaccine, YES you need to continue to wear a mask, cont. hand washing & social distancing - so as to continue to protect yourself and others. While vaccinated you can still become infected and spread infection. https://t.co/TkcSNx0hF1

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A oatint infected with COVID-19- Yes they should get vaccinated ~90days after infection has resolved.Antibody testing is not needed before you are vaccinated. Evidence suggests that reinfection is uncommon in the 90 days after initial infection. https://t.co/TkcSNx0hF1.

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Preprint results of the REMAP-CAP trial in the UK shows that IL-6 inhibitors, when given within 24 hrs of ICU entry for COVID-19, lowers mortality rate by 36%. Hosp mortality in 353 TCZ was 28%, 48 sarilumab was 22% in 402 controls was 36%. https://t.co/fkjOz99t0l

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ACR Convergence 2020 Late Breaking Abstracts available from the ACR "Spotlight" slide give away. 10 slides on COVID, Tyk2 in PsA, FAST febuxostat study, Tofa in AS and novel drugs for SLE and PSS https://t.co/DvcDyusCUR

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RheumNow Podcast is up! Benlysta safety, HCQ lowers thromboses, HCQ adherence, Telemedicine, Actemra in COVID,, 2021 looking forward and zoomatology! Watch it here>> https://t.co/PtfEUPB1hc or listen to podcast on Apple> https://t.co/FHJv01AAbC or Android>https://t.co/Iylluqqeej

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