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Immune Checkpoint Inhibitor Associated Arthritis

Jack Cush, MD May 30, 2022

Immune checkpoint inhibitors (ICIs) have dramatically improved outcomes in numerous cancers but have been hampered by a growing spectrum of immune-related adverse events (irAEs). Rheumatic complaints may be less frequent than other irAEs associated with ICI in cancer patients.

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Bridge Prednisone Use Fails to Improve Outcomes

Jack Cush, MD May 30, 2022

A one year, X-ray outcome trial has shown that the initial use of prednisone (high or low dose) in newly treated active early rheumatoid arthritis (RA) did not improve radiographic outcomes.

RNL 2022: Rheumatoid Arthritis - Best Management Last week's Tuesday Night Rheumatology, hosted by Dr. Jack Cush, featured highlights from the 2022 RheumNow Live Rheumatoid Arthritis - Best Management Pod, followed by a lively audience Q & A. https://t.co/trgaAqbB5J https://t.co/OiFd66ZanY

https://bit.ly/3wZKr1S

Is Gout Protective Against Dementia? People with gout appeared less likely to develop dementia than age- and sex-matched peers, a database study from Korea found. https://t.co/I0eW805oqR https://t.co/BeQEcjxOIo

https://bit.ly/3N0IIiF

Cardiovascular Risk in Calcium Pyrophosphate Deposition Disease A recent EHR study shows that acute CPPD crystal arthritis was significantly associated with elevated risks for non-fatal CV events. https://t.co/c0Nbjko3OQ https://t.co/SC9J80ROFT

https://bit.ly/38xW8Uk

Watch: Who Killed Caravaggio? Peter Nash, MBBS, FRACP shares thoughts on what or who exactly killed Caravaggio six centuries ago. https://t.co/9iOlArIIpb https://t.co/GQX8aDZGjy

https://bit.ly/3O0iiOf

Increasing Corticosteroid Use in Non-Hospitalized COVID-19 JAMA reports that despite NIH recommendations, non-hospitalized COVID infected patients were oftent prescribed systemic corticosteroids. https://t.co/1BADbI5j3z https://t.co/QtZZd7UJkc

https://bit.ly/3lX8XKO

Retrospective pregnancy outcome study in 154 Rheumatic pts. Systemic sclerosis pts had higher risk of adverse preg outcomes (vs HC - 60.6% vs 10.0%; OR = 14; SSc had increase in 1st trimester miscarriage, preeclampsia, SGA & Preterm https://t.co/hfd6SsCRmr Conclusions

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Single center muscle bx of 860 pts muscle biopsy had 531 with IIM (61.7%), 253 with non-IIM (29.4%), and 76 undiagnosed (8.8%). 7.9% were classified as immune mediated necrotizing myositis, 40% DM, 9.5% synthetase synd, IBM 0.3% https://t.co/KTsjpu0qPY

https://bit.ly/3NLmMI3

Long COVID Manifestations The acute consequences of a SARS-CoV-2 infection may be bothersome or devastating, but the long-term consequences may lead to so-called "long COVID" syndrome. Long COVID appears to affect up to 20% of those who survive COVID-19. https://t.co/Oh5R9xPKYD https://t.co/5iRVEjdWZW

https://bit.ly/3lSMgYh

Disease modification has been defined in multiple disease areas but no widely accepted definition exists for SLE. Learn about the benefits & why there’s a need to consider therapies that modify the immunologic mechanisms of SLE. Sponsored by GSK USMA https://t.co/GV20emEpki https://t.co/onX7To2zvn

https://bit.ly/3MIzxmP

Can SGLT2 Inhibitors Be Protective in Lupus and Vasculitis? SGLT2 inhibitors are all the buzz in the renal world with reports of a renal protective and mortality lowering effects https://t.co/b7YupKPJr7 #MedEd https://t.co/AYPeX360Gv

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Amitriptyline and FDA Treatments for Fibromyalgia #MedEd https://t.co/zA4rycnHg4 https://t.co/TxD1jp6XGf

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Watch: Lupus Nephritis: The Blind Men and the Kidney with Dr. Joan Merrill Joan Merrill discusses treatment of lupus nephritis. This was previously recorded at RheumNow Live 2022. https://t.co/9GRw5VGTKr https://t.co/PS6aEk1fsx

https://bit.ly/3Gsz85N

Visit @RheumNow podcast channel & hear experts from the #SLEEducatorsNetwork review a new framework for defining disease modification in SLE and why there’s a need to consider therapies that modify the immunologic mechanisms of SLE. Sponsored by GSK USMA https://t.co/gsrYmu5ufO https://t.co/Fmt21u3wUN

https://bit.ly/38pOSd0

Dr. Jack Cush reviews the news, regulatory updates and journal reports from the past week on https://t.co/V10S4oVFsv. This week gout worries, mortality risks, measuring anti-drug antibodies and a better way in lupus? https://t.co/iaMQZtzdLm https://t.co/Zu9VwKoCAc

Looking forward to reading/watching the coverage of #EULAR2022 by our outstanding faculty, including Drs., Rachel Tate @uptoTate, Kathryn Dao @KDAO2011, Robert Chao @doctorRBC , Janet Pope @Janetbirdope and Antoni Chan @synovialjoints . https://t.co/oBQCxzdzfF

Join experts from the #SLEEducatorsNetwork to learn more about our current understanding of SLE pathophysiology & why, given its progressive nature, there’s a need to try to change the course of this complex disease. Sponsored by GSK USMA @jeevsmd https://t.co/WkL1lU2JRJ https://t.co/g8iv6WUG5k

https://bit.ly/39SvCVK

Watch: Novel Treatment of SLE Dr. Sonali Narain discusses new insights on existing treatments and newly approved therapy and soon to be approved therapies for SLE. #MedEd https://t.co/7Op3R8IzV1 #MedEdTwitter https://t.co/qBMTbOBmyM

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Immune Checkpoint Inhibitor Associated Arthritis

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