The British Society of Rheumatology (BSR) has published evidence-based guidelines for idiopathic inflammatory myopathy (IIM) affecting juvenile and adult-onset disease. This rare condition has an estimated prevalence of 5-15 per 100,000 persons.
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Analysis of rheumatoid arthritis (RA) data from the British Society for Rheumatology Biologics Register shows that, even after failing three or more biologic or targeted synthetic DMARDs (b/tsDMARDs), patients may continue to benefit from repeated trials of unused b/tsDMARDs.
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A population based trial has shown that allopurinol use dose escalation and achieving target uric acid levels (with allopurinol), was not associated with increased mortality in patients with gout and concurrent CKD
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Disability claims in the U.S. related to rheumatoid arthritis (RA) were just as common in 2015 as in 1999, a government researcher found, against expectations that the advent of biologic therapy would have led to a steady decrease.
Phase 2b DBRPCT of Intranodular injections of adalimumab in 140 pts w/ Dupuytrens contracture showed signif reduction nodule size and hardness ((−4·6 vs −2·2; p=0·0002) at 12 months https://t.co/jXMAyeCL5t https://t.co/0PB81M3v5h
FDA update on Paxlovid - for use pts need to have:
- COVID test +
- Mild-mod dz @ risk for severe COVID
- High risk comorbidity
- potential interaction w/ statins, OCPs, HIV meds
- Dose adjust (nirmatrelvir) w/ CKD
- Dose 3 tabs bid x 5d
- Watch LFTs
https://t.co/oSqwlKijXq https://t.co/3Yx1C23QSz
Study of 13 European registries on durability/effect of interleukin-17 (IL-17) inhibition with secukinumab: among 2,017 PsA on secukinumab, retention rates were 86% and 76% at 6 and 12 mos, with 12 mo remission rate of 11% to 16% https://t.co/03sJBSbUy6
Did you miss last night's TNR on RA, improving future therapy?
We've got you covered. Listen to the playback here.
https://t.co/ci6TZOw3VX https://t.co/31gRUaKbQm
Good free patient info handout on LUMBAR SPINAL STENOSIS from JAMA https://t.co/0CkSR2gqaT
Korean Health Insurance claims data looked at risk of Aortic Regurgitation, Atrial Fib in Axial Spondyloarthritis - 3:1 comparison of normals found axSpA (n 8877) at signif higher risk for aortic regurgitation (HR 2.55) & AF (1.20) https://t.co/BXLDymQDKZ https://t.co/YtUbwmKpkG
RUXCOVID phase 3 RCT ruxolitinib (5mg bid x 14d) + plus standard care in 432 hospitalized COVID-19 showed no benefit over placebo in day 29 primary outcomes (death, respiratory failure (invasive ventilation), or ICU care. https://t.co/eyAit2uOLi https://t.co/R9rA1A4dm5
Neural networks of high-res quantitative CT (HR-pQCT) scans allowed for 3D imaging of MCP2 to differentiate normals from #RA & #PsA. 932 of 617 ppts correct AuROC for HC 82%, RA 75%, PsA 68%. UA pts read as 86% RA,11% PsA, & 3% HC https://t.co/wSQgllYgug https://t.co/yA6g55SpeC
Thanks so much to all who contributed to April's PsA All the Way campaign on RheumNow. You can find all our PsA content at the link below. Did you learn anything new about PsA from our coverage?
https://t.co/Mo7Yf2cu4i https://t.co/LvpuLtF4Mv
Retrospective study of 71 adult-onset Still’s disease pts Rx 1st w/ High-dose glucocorticoids shows 41% failed to respond (poor outcome) by week4 w/ WBC as best predictor. If WBC < 13K 60% responded; if ≥13K only 23.5% https://t.co/tMNDgoqP14 https://t.co/xJrIEUU6iK
TLR7 signaling impt to SLE as it drives type I IFN & activation of autoreactive B cells. Nature reports missense TLR7 (Y264H) variant from severe lupus induces guanosine & cGMP & causes murine lupus when introduced into mice. https://t.co/mzAWd3Pke8 https://t.co/knwa7fBLxk
"Belt & Suspenders" strategy - both COVID-19 vaccination & PrEP (Evusheld) needed to prevent SARS-CoV-2 in moderately to severely immunocompromised pts (transplant, cancer, immunodeficiency) and active poorly controlled autoimmune Dz https://t.co/RmflniD7rD https://t.co/K7pmQtqcOb
TONIGHT! Join us at for Tuesday Night Rheumatology at 7pm ET.
This webinar will share highlights from these lectures followed by live audience Q & A:
Treatment Choices in Refractory RA
Adherence to Rheumatoid Therapies
Precision Medicine in RA
https://t.co/8t6z8Y3JR9 https://t.co/xmIRA7faP5
Rheumatologic diagnosis through hand exam by Dr. Sarah Chung @ACPinternists #rheumatology #rheumtwitter #MedEd #rheumatoidarthritis #BJHM #Hospitalmedicine #IM2022 #MedTwitter 👇🏽 https://t.co/qR4zNa4NcX
Patient with new onset Colitis while on secukinumab, but is this drug-induced?
https://t.co/tpipGFOHI4 https://t.co/h4QujJdU8O
Leflunomide responses in #RA assoc w/ high metabolite levels (A77 1726). In 115 LEF Rx Pts, 40% had LDAS/remission. A77 1726 levels neg correlation w/ DAS28-ESR (r = − 0.42, p < 0.001). Levels >10µg/mL & LDAS PPV 70%; NPV 93% https://t.co/V32wUGVWLM https://t.co/L9DwZBwet9


