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CXCL5 Therapy in Lupus?
EurekAlert!
A new study has shown that restoring the balance of a protein in blood may be a promising treatment option for systemic lupus erythematosus.
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Lupus Linked With Greater Risk of Cardiovascular Complications of Childbirth
Pregnant women with systemic lupus erythematosus (SLE) were more prone to cardiovascular complications during delivery, and their risk seems to have increased over the past 15 years, according to national administrative data.
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Just Can’t Get Enough of Hydroxychloroquine
When it comes to hydroxychloroquine dosing, issues on efficacy, toxicity and therapeutic thresholds may affect the optimal use of this important drug.
Following are three abstracts presented during the meeting that address these topics.
Lupus Research Alliance announced 2022 Distinguished Innovator Award recipients:
- Hongbo Chi, PhD, Exploring Metabolism of Follicular Helper T Cells & Lupus Progression
- Joseph Craft, MD: Processes Enabling T Cells to Be Destructive in Lupus Nephritis
https://t.co/yI2NlCHaBi https://t.co/fevBTkaxCY
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Practical Guidance for the Clinical Rheumatologist in Unplanned Pregnancies
Women of reproductive age comprise an overwhelming majority of patients with rheumatic and musculoskeletal disease.
https://t.co/45ABQ0e2Qy https://t.co/dhLqzjf9uL
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From a cohort of 689 SLE pts, prevalence of lupus pericarditis was 16.4% Pericarditis was signif assoc w/ renal dz (p 0.003), lymphopenia (p <.0001), thrombocytopenia (p 0.004), +APL Abs (p = 0.002) https://t.co/BndDu21aXF https://t.co/Umbq3rsF1y
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Review of the Rheumatic causes of Pericarditis and their management. Causes: SLE, RA, MCTD, Myositis, EGPA, GPA, IgG4-rel Dz, FMF, TRAPS, CAPS, AOSD, JIA, Sarcoidosis, Kawasakis, GCA, Takayasu's https://t.co/h6zpTOIuyu https://t.co/Gy3Eaqz8sM
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Study 119 SLE pts w/ SLEDAI-2K of 13.5 @Dx & 2.8 @ 1st birth. Half had 1+ flares at mean of 9 mos after birth. Pts in remission had less flares (37% vs 61%; p=0.008). SLE flares during pregnancy had more flares in F/U (76% vs 47%; p=0.019) https://t.co/3u3agu9wDj https://t.co/twj4YYclRz
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Tight control of proteinuria in newly diagnosed lupus nephritis
The last 3 years have been exciting times in the field of lupus nephritis (LN) with two new licensed therapies, belimumab (BAFF-inhibitor) and voclosporin (calcineurin-inhibitor).
https://t.co/InkX6I7qUm https://t.co/U1M1DtF8Id
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Inadequate Dosing of Hydroxychloroquine Leads to Hospitalizations in SLE
https://t.co/ZktIKo1eVl https://t.co/dtxVXZFXpk
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Review of 120 pts w/ Catastrophic antiphospholipid syndrome showed that 54% had skin involvement & was 1st APS sx in 35%. Findings: livedo racemosa (45%), necrosis/ulcers (42%), splinter hemorrhages (29%), distal edema (23%), purpura (14%). https://t.co/HsVWlebfL2 https://t.co/dixoeHNkFQ
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SLE preg delivery hospitalizations (77560) was associated with increased risk of CV complications, including preeclampsia [aOR 2.12] , peripartum cardiomyopathy (4.42), CHF (4), arrhythmias (2.2), AKI (7.7), stroke (4.8), VTE (6.9) w/ incr hosp costs https://t.co/PF6P8oDWZB https://t.co/jA2pHcciB1
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SLE: Variability in Racial Disparities in Pregnancy Outcomes
Significant disparities exist in pregnancy outcomes in women with SLE, w/previous cohorts identifying Black women as having a higher risk of maternal mortality compared to White women w/SLE.
https://t.co/1PrJYpMcHx https://t.co/YN7K0Gf5Jl
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Dr. John Cush RheumNow ( View Tweet)
Lupus Linked With Greater Risk of Cardiovascular Complications of Childbirth
Pregnant women with SLE were more prone to cardiovascular complications during delivery, and their risk seems to have increased over the past 15 years, according to data.
https://t.co/mRUOVrKbt2 https://t.co/m18DWxSV20
Links:
Dr. John Cush RheumNow ( View Tweet)
Study of 294 SLE pts on HCQ (2005-2021): 37 (13%) developed CHF w/ low EF (HFrEF), arrhythmia or cardiac death. After adjustments, wt-based dosing of HCQ not assoc w/ cardiac events(sHR 0.62; 0.41,0.92) & may decrease risk in non-smokers https://t.co/11dneH04bv https://t.co/pp0ELe5mqV
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https://t.co/iylzzYRVAB https://t.co/7rKQShIzs5
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Dual target blockade may be better than one in SLE
Inhibition of B-cell Activating Factor (BAFF) has revolutionised the treatment of patients with systemic lupus erythematosus (SLE).
https://t.co/uu6ygb4l8B https://t.co/nLO3oSiEVa
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Future therapy? Nanoparticles laced with rapamycin to nanoparticle stimulate regulatory T cells to suppress autoimmune disease (tested in a mouse model). https://t.co/JHFh82siff https://t.co/Y8itPXiPho
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Impressive free read and review of Neutrophils and Netosis in Autoimmune and Autoinflammatory disorders (Nature Reviews) from Kapland & Wigerblad at the NIH. https://t.co/w4cIwcQMkt https://t.co/ReA9xM2X4j
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Topic Podcasts - Lupus Part2
#ACR22 Daily Recap: Saturday Recap New Treatments for SLE?
https://t.co/uRI3Q3eI6E https://t.co/wBXfXw7z8J
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