The American Society of Clinical Oncology, Inc (ASCO) has updated its guidelines and recommendations for the management of immune-related adverse events (irAEs) in patients treated with immune checkpoint inhibitor (ICPi) therapy. Below are select statements from this guideline.
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Lupus management is guided by assessment of both clinical and serologic features; but what happens with the patient with systemic lupus erythematosus (SLE) serologically active, but clinically quiescent (SACQ)? A large cohort study shows that nearly one-third of such patients may flare
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New research to be presented this week at ACR Convergence, the American College of Rheumatology’s annual meeting, shows a relationship between genotype, bone marrow failure and survival in patients with the rare autoinflammatory disease VEXAS syndrome, which was only identified in 2020.
Clues to Survival and Mortality with VEXAS Syndrome
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#ACR21 is just days away and we want to see your best images of learning virtually, missing a meeting in San Francisco, wellness, or break time activities.
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22 inactive (86%) #RA pts were treated with checkpoint inhibitors & Immune-related adverse events occurred in 7 (32%; two severe AE) leading to 6/22 D/C. RA flares occurred in 12 (55%); 10/12 Rx with steroids & good response. https://t.co/zemGVZOnYL
Study 144 pts Rx w/ Rituximab for Autoimmune renal Dz (AAV, FSGS, IgG4RD, LN, etc). 17% had Severe infections (SIE) w/in 3 mos; mostly pulm & GU. Risk factors=BMI, high creatinine. Hypogammaglobulinemia was frequent (58.5%) but not associated with SIE https://t.co/2jaxC4xLhc https://t.co/ajUKI35q2h
Early RA cohort (CATCH) 1891 early RA, 30% Rx oral steroids as bridge therapy; but 30% of these did not taper or D/C steroids after 24 mos. Early GC use assoc w/ age, unemployment, high Dz activity, later biologic use. https://t.co/dva1A6QHAk
WATCH: QD Clinic - Who is Immunosuppressed?
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Large GWAS Study Reveals Genetic Basis for Osteoarthritis Phenotypes
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Systematic review of dietary interventions for RA - 30 RCTs, 1063 pts; Pain was most reported outcome, sporadic studies showed occ. lowering of ESR, CRP, TNF, Plts, Igs, etc. Few studies show Anti-inflammatory diets may effective lowering DAS in RA https://t.co/B46NrVkwcK
#ACR21 is just days away and we want to see your best images of learning virtually, missing a meeting in San Francisco, wellness, break time activities, etc!
Tweet your pic and make sure to include #RheumPix and #ACR21 and we’ll RT our favorites. https://t.co/ey9iZ9QaKO
QD Clinic - Alopecia Rules
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New podcast available for download on RheumNow!
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ICYMI: ACR publishes a "White paper on Antimalarial Cardiac Toxicity"- reviewing drug hx,indications, effects & rare risk of arrhythmias, conduction abnormalities, cardiomyopathy, QTc prolongation. torsade de pointes. No evidence for routine ECG monitoring https://t.co/2aemSKzk3T https://t.co/4CrqO0OKlz
ICYMI: The Sacroiliac Joint - some call this a symphysis, but it is an "amphiarthrosis", or sliding joint, with minimal movement; Only the lower 1/3 of the joint is synovial lined -- this is where one should look for sacroiliitis. https://t.co/8uD13h2qHZ https://t.co/D3UERVXrgX https://t.co/2DToXTQCi5
ICYMI: Platelet-Rich Plasma Injections Fail in Ankle Osteoarthritis
https://t.co/Fmf8f2C3Y4 https://t.co/8Tw4fAhREd
ICYMI: Systematic review of dsDNA studies (byfluorescence immunoassay) included 1977 total patients, 47% with SLE == over all dsDNA had >90% for specificity and a pooled specificity of 94.7% (95% CI 91.67%-96.67%) https://t.co/Nk8h9fDYpE https://t.co/RcmewQpN7B
Way to Go (big) Seoyoung!! https://t.co/G59UTTMTIb


