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Large GWAS Study Reveals Genetic Basis for Osteoarthritis Phenotypes

Jack Cush, MD Oct 29, 2021

Cell has published the results of a multinational, GWAS meta-analyses of 826,690 individuals that included 177,517 osteoarthritis patients, finding 52 previously unknown osteoarthritis (OA) genetic risk variants and linking OA genetic risks with joint distribution and pain

Systematic review of dietary interventions for RA - 30 RCTs, 1063 pts; Pain was most reported outcome, sporadic studies showed occ. lowering of ESR, CRP, TNF, Plts, Igs, etc. Few studies show Anti-inflammatory diets may effective lowering DAS in RA https://t.co/B46NrVkwcK

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#ACR21 is just days away and we want to see your best images of learning virtually, missing a meeting in San Francisco, wellness, break time activities, etc! Tweet your pic and make sure to include #RheumPix and #ACR21 and we’ll RT our favorites. https://t.co/ey9iZ9QaKO

QD Clinic - Alopecia Rules QD Clinic is sponsored by https://t.co/V10S4oVFsv's coverage of #ACR21 https://t.co/8w6xQS5uPz https://t.co/FDvXVNkvVy

New podcast available for download on RheumNow! https://t.co/zuowQS3pTK https://t.co/vZeUMgWwEr

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ICYMI: ACR publishes a "White paper on Antimalarial Cardiac Toxicity"- reviewing drug hx,indications, effects & rare risk of arrhythmias, conduction abnormalities, cardiomyopathy, QTc prolongation. torsade de pointes. No evidence for routine ECG monitoring https://t.co/2aemSKzk3T https://t.co/4CrqO0OKlz

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ICYMI: The Sacroiliac Joint - some call this a symphysis, but it is an "amphiarthrosis", or sliding joint, with minimal movement; Only the lower 1/3 of the joint is synovial lined -- this is where one should look for sacroiliitis. https://t.co/8uD13h2qHZ https://t.co/D3UERVXrgX https://t.co/2DToXTQCi5

ICYMI: Platelet-Rich Plasma Injections Fail in Ankle Osteoarthritis https://t.co/Fmf8f2C3Y4 https://t.co/8Tw4fAhREd

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ICYMI: Systematic review of dsDNA studies (byfluorescence immunoassay) included 1977 total patients, 47% with SLE == over all dsDNA had >90% for specificity and a pooled specificity of 94.7% (95% CI 91.67%-96.67%) https://t.co/Nk8h9fDYpE https://t.co/RcmewQpN7B

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Way to Go (big) Seoyoung!! https://t.co/G59UTTMTIb

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Congrats!!! https://t.co/v6EUyDJ5lJ

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Primary care docs: please remember that it is not enough just to treat the acute gouty episode. This truly is a chronic debilitating disease #MedEd #gout https://t.co/lXTIqZXA1m

Janet Pope on Twitter: "#ClinicalPearl. What do you see on 3rd DIPs? Note …

Beautiful, isn’t it? https://t.co/Ga0840KBcW

Ultrasound Rheumatology UZR on Twitter: "Gout: The video shows a petri dis…

If you see a patient with fatigue and arthralgias please screen for depression before you order a battery of serologies. Pain is a common feature of depression #MedEd https://t.co/0FCugZRbgI

ICYMI:New Download Available! FDA EUA for Baricitinib in COVID https://t.co/yTQLb7DDvR https://t.co/p6NPCXa0Fn

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Sign up today to receive #ACR21 news and select topic emails throughout the conference. #RheumNow https://t.co/riyAnrRHhX https://t.co/XIJIMdvQ2g

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Biologic Use and the Risk of Serious Infection in Psoriasis Patients https://t.co/zU8ZaYjGyf https://t.co/jpAITJOFpi

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Rheumatologists are setting cardiology straight about hydroxychloroquine and chloroquine. This, and a special recognition of parent-child rheumatologists, along with the news and articles from this week on RheumNow. https://t.co/zuowQS3pTK https://t.co/eToS9zjqss

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BEAT-LUPUS: Sequential Belimumab After Rituximab in SLE https://t.co/4hUBRnhdhl https://t.co/xj900Vd8qt

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Nationwide 2 yr F/U study, 11 centers, 300 pts with early (1.2 yrs) systemic sclerosis shows, despite most (2/3) on immunosuppressives, 71% progressed to diffuse SSc, 21% worsen Skin, 23% worse FVC & 6.6% died (cardiac, GI, ILD) https://t.co/UfagmX2S16

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Large GWAS Study Reveals Genetic Basis for Osteoarthritis Phenotypes

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