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Vitamin D Fails in Postmenopausal Osteoporosis Prevention
JAMA reports that investigators from the University of Wisconsin in Madison studied the impact of vitamin D supplements on 230 women who were at least five years past menopause but no older than 75, and without osteoporo
Read ArticleNSAIDs are Risky in Patients with Chronic Kidney Disease
Little is known about what happens when NSAIDs are used in patients with chronic kidned disease (CKD), especially those with hypertension.
Read ArticleNot All Placebos are Equal: The Needle is Mightier than the Pill
Placebos are necessary to determine the “true effect” of any medical intervention. As such, they have become the cornerstone of evidence-based medicine, randomized controlled clinical trials and novel drug development.
Read ArticleLong term Denosumab Use Shows Favorable Outcomes: Results from the FREEDOM Extension Trial
Osteoporosis is a disease characterized by increased bone loss that outpaces the grown of new bone. As a result bones become less dense and more fragile and brittle; porous bones are more prone to fracture.
Read ArticleLithium May Have Chondroprotective Effects in OA
Several studies have suggested that lithium chloride exhibits significant chondroprotective effects on cartilage degradation (in animal models) in response to inflammatory cytokines.
Read ArticleFDA Strengthens MI and CVA Risks Associated with NSAIDs
FDA announced yesterday they would strengthen warnings stating that non-aspirin nonsteroidal anti-inflammatory drugs increase the chance of a heart attack or stroke. This applies to both prescription and OTC NSAIDs.
Read ArticleThe Unproven Use of Stem Cell Therapy in OA of the Knee
Regenerative medicine and the use of bone marrow stromal cells (or mesenchymal stem cells - MSC) is controversial in many areas of medicine, including osteoarthritis. MSC use is at a very early stage in orthopedic research, but has been investigated in osteoarthritis of the kn
Read ArticleRight Knee Pain - What's Your Dx?
A 36 year-old white male butcher has right knee pain for 3 weeks. He noted a similar episode 5 years earlier and admits to a traumatic fall on that knee years ago. He denies fever, redness, warmth, other joints or other past medical problems. He only takes OTC ibuprofen prn.
Read ArticleConservative Equals Surgical Management of Lumbar Spinal Stenosis
A randomized controlled trial of compared the outcomes of surgical decompression or physical therapy in 169 lumbar spinal stenosis patients. After two years, intention-to-treat analyses revealed no difference between groups.
Read ArticleIntraarticular Hip Injection of Ketorolac Equals Steroid Responses
Using ultrasound guided intraarticular injection of the hip, 98 OA of the hip patients were randomized to receive IA ketorolac or triamcinolone. At, 1, 3, and 6 mos pain scale and Harris hip scores were improved equally in both groups with no statistical differences.
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Increasing Incidence of Osteomyelitis
A Mayo Clinic analysis of trends in osteomyelitis disclosed 760 new cases between 1969 and 2009 in Olmstead county. Rates increased from 11.4 cases per 100,000 person-years for the period from 1969 to 1979 to 24.4 per 100,000 person-years in the period from 2000 to 2009.
Read ArticleKnee Implant Forecast from 2012 - 2018
The global knee implants market was USD 8.4 billion in 2011, and it's forecasted to reach USD 15 billion in 2018, with compound annual growth rate of 8.64% during 2011 to 2018. The U.S.
Read ArticleEczema associated with osteoporosis and fractures
NHANES data shows eczema is associated with a higher rate of fractures and osteoporosis. Of the nearly 5,000 people included in the study, seven percent reported a diagnosis of eczema.
Read ArticleOsteoporosis Induced by Bariatric Surgery
Although the cause is not clear, women who have weight loss surgery have a higher risk of thinning bones (osteoporosis) and fractures over time, according to a new analysis of a Swedish study.
Read ArticleUnderuse & Overuse of DXA Screening
A US Preventive Services Task Force recommends DEXA screening in women >65 yrs and only in women 65 yrs if there is a significan risk of fracture. Amarnath and coworkers studied 50,995 women in primary care, aged 40-85 years, between 2006-2012.
Read ArticleMen are Less Likely to be Screened for Osteoporosis
Study by Dashkova et al finds males less likely to have their bone density checked, but suffered worse outcomes. "We were surprised at how big a difference we found between men and women regarding osteoporosis," study author Dr.
Read ArticleTanezumab in Osteoarthritis: Data Presented at OARSI
Pooled analyses of the tanezumab (a nerve growth factor inhibitor) phase 3 studies was presented at the 2015 Osteoarthritis Research Society International (OARSI) World Congress.
Read ArticleDiet, Exercise and Glucosamine Fail to Prevent OA in Overweight Females
An at-risk population of 407 middle-aged overweight women (BMI ≥ 27 kg/m2) without clinical signs of knee osteoarthritis were prospectively studied for 2.5 years and randomized to receive either glucosamine or diet and exercise in a double-blind, placebo-controlled trial.
Read ArticleReview of Bisphosphonates and Atypical femoral fractures
The Journal For Nurse Practitioners provides a succinct overview of atypical femoral fractures and bisphosphonates. These popular agents account for 14 million prescriptions annually in the United States.
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