Faith and Miracle Larry This week on the podcast, Dr. Jack Cush recalls what life was like early on during COVID, from March to June of 2020. https://t.co/SfidfBF1En https://t.co/Jnv6moxYwQ

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#RNL2023 @RheumNow Dr. Stanley Cohen: possible adverse effects of JAKi -Herpes zoster, other infections -Malignancy -Occasional cytopenias -LFTs (with DMARDs) -Incr Cr or CPK -Acne -Incr lipids -GI perf -VTE Which do you counsel with your patients? https://t.co/AZDKShOPbU

Dr. Deanne reminds us that RA is worth preventing for many reasons. #RNL2023 @RheumNow https://t.co/va0RmdhUQR

Dr. Kevin Deane on preclinical-RA Very complex history on development of RA with multiple phases before detectable RA shows up in your clinic. #RNL2023 @RheumNow https://t.co/vzQFhik0aK

#RNL2023: Kevin Deane: Anti-CCP positive leads to a 20-30% risk for articular clinical RA within 3-5 years @RheumNow https://t.co/skp1K4r1hF

STOP-RA study on HCQ preventing RA... HCQ did NOT prevent RA development in pre-RA pts @RheumNow #RNL2023 https://t.co/Vv3szkqxWh

#RNL2023 @RheumNow Kevin Deane presents his STOP RA Trial HCQ is safe and easy - can you use it in pre-clinical RA to prevent disease? NO EVIDENCE of decreased progression of RA in HCQ compared to placebo https://t.co/1OSVubd9rO

Treatment with MTX in early CCP+ RA thought to be effective in slowing disease however StopRA study did not show a difference between HCQ and PBO in patients. We need to know more about HCQ vs MTX in this space! #RNL2023 @RheumNow https://t.co/7asmvVfXiC

The holy grail. How to stop #rheumatoid #arthritis in at risk Pts. Who to treat, when to stop? Many RCTs but no home run-NNT is high. #MTX and a diff study #Abatacept that work while on Rx and #Rituximab, most don’t work esp after stopping Rx @kevindeane #RNL23 ⁦@RheumNow⁩ https://t.co/BkIxxS0ecn

Dr. Deane's current management of "pre-RA" pts - carefully eval for synovitis - lifestyle factors - stop smoking, diet, dental hygiene - educate pt on ~30% risk - annual in-person follow up @RheumNow #RNL2023 https://t.co/Z0t0Yibyri

How do you prevent RA in at-risk patient? Smoking cessation! Healthy weight and exercise! Diet! Periodontal health! 🚭🏋️🥕🦷 Education & follow-up! Not robustly proven to prevent/delay RA, but may be more important than early DMARD intervention! Kevin Deane, MD #RNL2023 @RheumNow

Natural history of RA by Kevin Deane #RLN23 ⁦@RheumNow⁩ https://t.co/ab0cafDblz

The amazing JAKs The many JAK/TYK targets approved for multiple conditions Coming soon: UPA for Crohn's - first indication for Crohn's disease #RNL2023 @RheumNow https://t.co/Pf3gzrdyeq

Dr. Stanley Cohen on JAKinibs: Very concise and informative timeline on the multiple JAKinibs approved for multiple conditions @RheumNow #RNL2023 https://t.co/3ZZHr0akrR

JAKi cycling, likely something we all do/consider in clinic. Dr. S. Cohen reviews the JAK-pot study which shows good, expected results between cycling in patients. #RNL2023 ⁦@RheumNow⁩ https://t.co/qBau79o0VQ