Predictors of Serious Infections with Rituximab
The risk of serious infectious events (SIE) with rituximab (RTX) is similar to that seen in other biologics (e.g., RA: 2% or 4.3/100PY), but with prolonged use the risk may change.
RheumNow Podcast – Medical Selfies (5.24.19)
Dr. Jack Cush Reviews the news and journal articles from the past week on RheumNow.com
Nintedanib May Benefit Systemic Sclerosis Related Interstitial Lung Disease
The NEJM reports a randomized placebo controlled trial of nintedanib, a tyrosine kinase inhibitor, in systemic sclerosis patients with interstitial lung disease (ILD) resulted in less pulmonary decline, but had no effect on other features of systemic sclerosis.
Ustekinumab Effective in Behcet's Disease
A small prospective study has shown that ustekinumab is safe and effective in Behçet's disease (BD) with recurrent oral ulcers (OU).
Higher Comorbidities in Hidradenitis Suppurativa
JAMA Dermatology reports that patients with hidradenitis suppurativa have significantly more comorbidities than do patients with psoriasis.
AAD/NPF Guidelines on Biologic Use in Psoriasis
Menter and colleagues from the American Academy of Dermatology (AAD) and National Psoriasis Foundation (NPF) have published their expert consensus guidelines for the use of biologics in psoriasis.
Canadian Vaccination Guidelines for the Immunosuppressed
A multidisciplinary Canadian task force has developed guidelines for vaccination in patients receiving immunosuppressive therapies, based on the evidence that immunosuppressive use in immune-mediated disease may be associated with an elevated risk of infections.
RheumNow Podcast - MTX vs. Etanercept in Psoriatic Arthritis (2.15.19)
Dr. Jack Cush discusses the news from the past week on RheumNow.com - including the SEAM trial, MRI guided T2T, biologics and infection, contraceptive use, ANA negative lupus, etc.
RheumNow Podcast – Downside of Lupus (2.9.19)
Dr. Jack Cush reviews this past week's news and reports from RheumNow.com:
RheumNow Podcast - Scurvy and Mechanics (2-1-19)
Dr. Jack Cush reviews new journal articles, news reports, and more from the past week on RheumNow.com.
IL-6 Blocker Succeeds in Real-World Vasculitis
Tocilizumab (Actemra) was effective for refractory giant cell arteritis (GCA) in real-world practice, although serious infections occurred relatively frequently, Spanish investigators reported.
2018 Rheumatology Year In Review
This annual appraisal of hallmark moments, news and research articles from 2018 are gleaned from that published in RheumNow during the last year and filtered by other news sources and literature review. The top 10 list herein is rooted in what rheumatologists should know and what will likel
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Rheums--have a question or case for Jack Cush? Record it here and we may feature it on an upcoming podcast. Tell us your name and where you practice rheumatology.
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Dr. John Cush @RheumNow ( View Tweet )
4 years 3 months ago
The CDC has reported that mRNA vaccine effectiveness against COVID-19–associated hospitalizations was sustained over 24 weeks; but there is evidence of waning protection amongst the immunosuppressed.
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Dr. John Cush @RheumNow ( View Tweet )
4 years 3 months ago
Important read re:G6PD testing prior to HCQ
Rare & not assoc w/hemolytic anemia in this cohort, but only 11 pts with G6PDH deficiency
I'm v. skeptical of G6PD screening; cost (no HCQ in SLE) could easily be worse than benefit (avoiding hemolytic anemia)
Do you routinely test? https://t.co/HI2PuF1Xq9
Mike Putman @EBRheum ( View Tweet )
4 years 3 months ago
CMAJ: nice full read review of biologic use during pregnancy.
1) autoimmune/arthritis pts may use biologics during pregnancy
2) mom/infant should avoid live vax 1st 6–12 mos
3) Minimal biologic transfer in breast milk
4) no risk of congenital anomalies
https://t.co/mlZTrDjXSi
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Dr. John Cush @RheumNow ( View Tweet )
4 years 4 months ago
Top Tweet Last Week:
Potential Birth Defects with Hydroxychloroquine
HCQ is one of the safest meds used in rheumatology, but there is new claims data suggesting a small increase in the risk of malformations associated with first-trimester HCQ use.
https://t.co/IHNKjHVXaU https://t.co/Oay2ayVr9m
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Dr. John Cush @RheumNow ( View Tweet )
4 years 4 months ago
These companies do auto-inflammatory gene testing in the USA.
@RWCSmtg https://t.co/89bWd0SiAI
Dr. John Cush @RheumNow ( View Tweet )
4 years 5 months ago
Serious problem! Pulmonologists believe that MTX causes and/or worsens ILD. MTX causes hypersensitivity pneumonitis, not ILD. RA, lupus DM, PSS cause ILD and they may need MTX to manage their disease. Do your own research, look at this paper to start. https://t.co/vUyCxJP2Mh
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Dr. John Cush @RheumNow ( View Tweet )
4 years 5 months ago
Download this week’s podcast titled “Good as I Ever Was”. You can find us on SoundCloud and wherever you download your podcasts.
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Dr. John Cush @RheumNow ( View Tweet )
4 years 5 months ago
Ten Things to Tell Patients About Diet and Rheumatic Disease: Dr. Eric Dein ( @ejdein1 )
https://t.co/q2Mc1gLZig https://t.co/iV5JO8m5Sv
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Dr. John Cush @RheumNow ( View Tweet )
4 years 5 months ago
#EULAR2021 - Day 3 Report
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Dr. John Cush @RheumNow ( View Tweet )
4 years 6 months ago
