“You Can Have it All” (4.7.2023) Save

Jack Cush, MD

Apr 07, 2023 1:36 pm

Dr. Jack Cush reviews the news and highlights from our "Women in Rheumatology" Campaign from last week on RheumNow.com

AMA survey shows 94% MD report delays in Pt care assoc w/ prior authorization. MDs spend 2d/wk on PA &1/3 hire added staff for PA. 4/5 PAs result in abandoned Rx. CMC has a proposed rule to speed up PA approval. Congress needs to act on this PA problem! https://bit.ly/3GnGNDg
Steroid-Sparing Rituximab in Polymyalgia Rheumatica BRIDGE-PMR proof-of-concept trial assessed the efficacy of RTX in patients with PMR and showed that a single 1000 mg dose of lead to a significant number of glucocorticoid-free remissions after 1 year. https://t.co/Jl0TMc7On0
Open-label Trial of 14 pts with MAS due to steroid refractory systemic JIA or adult-onset Still’s demonstrated the efficacy of IV emapalumab, an anti-IFNγ mAb. Demonstrated signif reductions in LDH, sIL-2R, Ferritin, CXCL9, & steroid dose https://t.co/vgxT5KzmQF
Inflammasome inhibitors in development: RRx-001 in cancer, ALS, parkinsons - OLT1177 in OA knee, gout, Schnitzlers - DFV890 in CAPs, knee OA - IZD174/334 in CAPS - ZYIL1 CAPS https://bit.ly/3zFg1mo
Among 182 adult #RA pts - half (50%) had Depression and 25% had anxiety. Patients with depression or anxiety had higher HAQ and DAS28 scores. Depression was more prevalent in females, housewives, & low education. Anxiety more in blue-collar workers https://t.co/C9Foulu29l
Abbvie has completed a phase II upadacitinib vs combo elsubrutinib/upadacitinib (ABBV-599) in active #SLE - M19-130 (SLEek) Phase 2 trial met the primary endpoint SRI-4 response and pred dose<=10 mg qd. No new safety signals - Phase III trial planned https://t.co/6CwS2AVamH
Antiphospholipid Antibodies With Incident Cardiovascular Events
EMA Final Update on JAK Inhibitors and MACE, Malignancy & VTE Risks https://t.co/rMEqodKdVN
DESIR - early SpA Cohort study of 494 pts (half F); w/ 6 yrs F/U, Women had higher ASDAS-CRP & PtGA (P < 0.0001; vs men), yet CRP was similar and structural damage more frequent in men (P < 0.0001). https://bit.ly/3UjqxJC
Analysis of 886 SpA pts in the Ankylosing Spondylitis Registry of Ireland shows women have worse BASDAI (4.57 vs 3.83, p < 0.01) & ASQoL (7.51 vs 6.12, p < 0.01) scores than males. higher scores in females due to all 6 BASDAI components https://t.co/2kt6t9MXUB
Pooled data from 3 RCTs in PsA compared tofacitinib vs. adalimumab in 816 pts. Baseline, women had higher TJC, enthesitis, HAQ-DI, FACIT-F (Males more dactylitis). Sexes had equal ACR20/50/70, PASI75, ∆HAQ-DI, & persistence, but females less achieved MDA https://t.co/LICWVjI2kH
US MD survey shows # active MDs grew 33% to 923 419 (2001-2021). But AVG weekly work hrs declined 7.6% (53 to 49 hrs/wk). Decline driven by MD males/Fathers (-12%), rural MDs, 45-54 yrs old MDs. Only MD mothers had signif. increase in work hours (+3%) https://t.co/1CR2ERPX5e
Aug 2022 Ann Int Med reports a Compensation study of 1435 matched male (881) & female (554) PCPs; Shows that despite being a growing share of the workforce, Women PCPs earned median of $58 829 less than male PCPs. https://t.co/iS9oFvdjgq
962 #RA pts from Leiden early arthritis clinic shows that in 2005 was a significant delay (~5wks) in referral of females vs male pts. The longer referral delays in female pts has since been eliminated. By 2020 the referral delay is same 4.7 vs 5.4 wks. https://t.co/JphiWWk85j
"You can have it all... ... but not all at the same time ... or all the time."- @UnaMakris @rheumnow Tuesday Night Rheumatology
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