ICYMI: Beyond the Needle: Redefining the Assessment of Lupus Nephritis

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Lupus nephritis is one of the most silent and severe manifestations of SLE. When not captured early, patients are at high risk of progressing to end-stage renal disease, which would require dialysis or transplantation. Renal biopsy remains the gold standard for diagnosis and disease classification. However, the procedure is invasive and very painful. Non-invasive measures are critical for early detection and continuous monitoring.

ICYMI: Are Emulation Trials a Fantasy?

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Are emulation ‘trials’ helpful, despite the biases that occur with observational data, or do they truly mimic the results of randomized controlled trials (RCTs)?

54K Peptic Ulcers Annually (12.13.2024)

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Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow.com

Rheumatoid Arthritis Boosts Risk for Some Types of Heart Failure

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Rates of heart failure with preserved ejection fraction (HFpEF) were doubled in patients with rheumatoid arthritis (RA) relative to other people of the same age and sex, researchers found.

Safety of Acetaminophen in the Elderly

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New research, led by experts at the University of Nottingham, has found that repeated doses of paracetamol in people aged 65 and over, can lead to an increased risk of gastrointestinal, cardiovascular and renal complications.

ICYMI: Say Goodbye to Methotrexate in PMR?

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For decades, glucocorticoids (GCs) have formed the backbone of polymyalgia rheumatica (PMR) management.

Outcome of Pain in Hand Osteoarthritis

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Leiden cohort study of hand osteoarthritis (HOA) patients shows that over 4 years, pain outcomes are variable, and not inevitably worsening.

Treat-to-Target LLDAS in Lupus

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Patients with highly active systemic lupus erythematosus (SLE) appeared to sustain much less organ damage and fewer disease flares when drug therapy yielded substantial relief, researchers found.

ICYMI: ORAL Surveillance - Is Statin Use the Problem/Solution?

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The findings from ORAL Surveillance Study have been a dominant conversation at recent ACR Convergence, with the seminal findings and subsequent analyses a target of debate. Subsequent post-hoc analyses, follow-up studies, and claims data analyses have been used to further interpret the data, though a clear answer on safety is not certain. A study presented on Sunday reported on a new post-hoc analysis that provides new insights.

Drug-Free Remission in Giant Cell Arteritis is Uncommon

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ICYMI: GLP-1 Agonists Show Promise in Slowing Kidney Disease in Lupus Nephritis

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A retrospective cohort study presented at #ACR24 explores the benefits of GLP-1Ras in reducing the risk of end-stage renal disease (ESRD) for patients with lupus nephritis. Drawing on data from the TrinetX global research database, the study examines how GLP-1Ras may reduce ESRD progression in a population where 10-20% progress to ESRD within five years, even with immunosuppressive therapies.

Healthy diet helps chronic pain

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Chronic pain is an acute and debilitating condition that affects millions of people worldwide. And while pain interventions are available, many people struggle without treatment at all.