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Periprosthetic Joint Infections

Recent NEJM has reviewed arthroplasty-associated infection and periprosthetic joint infections (PJI), noting this is a rare event; notably these infections are caused by skin microorganisms introduced during arthroplasty surgery or may be seeded post-surgically, via hematogenously spread or compromised local tissues (skin or bone).

JAK-pot Study: To Cycle or Switch after JAK inhibitor Failure?

Data from 17 international registries (JAK-pot collaboration) suggest that for Rheumatoid arthritis (RA) patients failing their first janus kinase inhibitor (JAKi), it did not matter if they were cycled to another JAKi or switched to a biologic disease-modifying antirheumatic drug (bDMARD).

Burden of BMI on Costs of Musculoskeletal Diseases

A cross-sectional global study shows a substantial impact of obesity and BMI on the health and economic impact of patients with musculoskeletal (MSK) disorders.

PsA Til Death Do Us Part (1.20.2023)

Dr. Jack Cush reviews the highlights from the past week on RheumNow.com.

AS, but not PsA, has Increased Mortality Risk

Inflammatory disorders are often accompanied by an increased mortality risk, either from secondary malignancy, infection or cardiovascular disease.

Phase III Trials Back Bimekizumab for Spondyloarthritis

Medpage Today

Bimekizumab, an investigational biologic drug targeting interleukin (IL)-17A/F, appeared highly effective in patients with axial spondyloarthritis (axSpA), researchers said.

Hydroxychloroquine Dose and Risk for Incident Retinopathy

A cohort study in Annals of Internal Medicine shows that higher hydroxychloroquine doses was associated with progressively greater risk for incident retinopathy.

Poorer health outcomes for at-risk patients with fractures

People at high risk of fracture who also have complex or multiple chronic medical conditions are less likely to receive treatment for the underlying osteoporosis and also have poorer health outcomes, according to a new study from the Garvan Institute of Medical Research.  

New Guideline: Vaccinations OK With Few Tweaks for Rheum Patients

MedPage Today

Nearly all available vaccines can be given to people with rheumatologic diseases, according to a new, detailed guideline from the American College of Rheumatology (ACR), though the timing for their administration and dosing of antirheumatic drugs may need adjustment in some cases.

Elevated Uric Acid Is Associated With New‐Onset Atrial Fibrillation

A Longitudinal Swedish study has shown that elevated serum uric acid (SUA) levels has cardiovascular implications and may predict the development of atrial fibrillation (AFib). 

Rheum Believe it Or Not (1.13.2023)

Dr. Jack Cush reviews the notable standouts in the news since the 1st of January.  Surprising reports on ferritin, alcohol benefits, cannabis for pain and a lower dementia risk with hydroxychloroquine.  Here are the links below.

RA Disease Activity and Alcohol Use

Despite its well known toxicities, alcohol is known to be antiinflammatory. The effects of alcohol use in rheumatoid arthritis (RA) is less known, but a recent study suggests that alcohol consumption was dose-dependently associated with lower disease activity and higher health-related quality of life in RA patients.
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