Nerve Growth Factor Inhibitor Compounds Cartilage Loss in Osteoarthritis
Nerve growth factor (NGF) is a key modulator of pain perception, Inhibitors of NGF are being studied in several chronic pain conditions, including osteoarthritis (OA).
News
Problems with Red Flags in Diagnosing Low Back Pain
There is considerable heterogeneity in "red flags" amongst numerous low back pain (LBP) guidelines worldwide. A "red flags" denotes a finding, which if present, imparts a significantly high risk of underlying serious spinal pathology with considerable subsequent morbidity or mortality.
Biosimilars are Bioequivalent to Original TNF Inhibitors
Chingcuanco and coinvestigators have reported on their comparative analysis of biosimilars and their originator TNF inhibitors in the current issue of Annals of Internal Medicine. (Citation source: http://buff.ly/2arTd1q)
Canakinumab Yields Genetic and Disease Modifying Effects in TRAPS Patients
Tumor necrosis factor (TNF) receptor-associated periodic syndrome (TRAPS) is an autosomal-dominant autoinflammatory disease resulting from mutations of the TNF super family receptor 1A (TNFRSF1A) gene.
Meniscal Tears May Not Need Surgery
A study published in the British Medical Journal examines whether knee surgery or conservative medical management benefits those with degenerative meniscal tears. (Citation source http://buff.ly/2awVbKu)
RheumNow Week in Review - 29 July 2016
Dr Jack Cush reviews this week's highlights from RheumNow.com.
Long-Term Safety of Adalimumab Reviewed
Burmester and colleagues have published their review of the long-term outcomes and safety issues with the TNF inhibitor, adalimumab (ADA). The analysis included 15,132 patients exposed to adalimumab in global RA clinical trials.
Pravastatin Improves Obstetric Outcomes in Anti-Phospholipid Syndrome Patients
Pregnancy complications of anti-phospholipid syndrome (APS) have included recurrent abortions, spontaneous fetal loss, preeclampsia, and premature birth. The etiopathogenesis of these events has been presumed to be placental thrombosis or infarction.
Novel Rise of Combined Dermatology-Rheumatology Clinics
Rheumatology News has a novel online report about combined rheumatology-dermatology clinics. In the last several years, there have been a few of these in operation (Boston, Chicago, Rhode Island).
RheumNow Week in Review – 22 July 2016
From tofacitinib developmental trials in RA and psoriasis and adherence to T2T in early RA to a rheumatology pearl about dapsone and much more, here are the highlights of what you may have missed on RheumNow.com this week.
FDA Panel Recommends Brodalumab Approval in Psoriasis
Valeant Pharmaceuticals International's experimental drug to treat psoriasis should be approved as long as certain measures are put in place to mitigate the risk of suicide, an advisory committee to the U.S. Food and Drug Administration concluded on Tuesday.
