Do You Have to be Overweight for GLP-1s to Work?

RheumThoughts: Do You Have to be Overweight for GLP-1s to Work?

Janet Pope, MD, MPH, FRCPC

Sep 22, 2026 8:54 am

Are there any data that GLP-1 RA drugs can be effective if a person has a normal BMI?

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Osteoarthritis, Obesity and GLP-1s

Sep 8, 2026

Article

Osteoarthritis, Obesity and GLP-1s

Tom Appleton, MD, PhD Sep 8, 2026

We all know that osteoarthritis is the most common form of arthritis in the world, and that obesity is its most modifiable risk factor. What I really want to focus on is the role that GLP-! receptor agonists might be playing in our management of osteoarthritis. So why does this matter?

Article

Bariatric Surgery in the Era of GLP-1RA

Satya Dash, MD Sep 14, 2026

Weight loss with lifestyle changes alone is difficult to sustain for most people. One reason for this is the weight loss associated endocrine milieu, which can decrease energy expenditure and increase the drive to eat. Therefore, we frequently use medications and/or bariatric surgery.

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Janet Pope, MD, MPH, FRCPC (63 Posts)

Dr. Janet Pope is a Professor of Medicine in the Division of Rheumatology at the University of Western Ontario (UWO), Schulich School of Medicine, London, Ontario, Canada. She is the Division Head in Rheumatology at St. Joseph's Health Centre, London. Her research includes studies in scleroderma, SLE and RA, including outcome measurements, clinical trials and disease manifestations. She has published over 450 peer-reviewed articles, 15 chapters, 500 abstracts and several Cochrane meta-analysis reviews. Mentoring of research students and trainees numbers more than 125. She has received the Distinguished Investigator Award from the Canadian Rheumatology Association, Rheumatologist of the Year from the Ontario Rheumatology Association, Department of Medicine Research Achievement Award, and the Dean’s Award of Excellence in Research. She has been inducted into the Canadian Academy of Health Sciences.