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Lovastatin Fails to Lower CRP and Activity in RA

Aug 04, 2020

Ridker and colleagues have shown that statins (3-hydroxy-3-methylglutaryl coenzyme-A (HMG Co-A) reductase inhibitors) are effective at treating hyperlipidaemia and lowering C-reactive protein levels; Aranaow and colleagues have shown that lovastatin, when given to rheumatoid arthritis (RA)

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RheumNow Podcast – COVID-19 Responds to Steroids (7.24.20)

Jul 24, 2020

Dr. Jack Cush reviews the News and Journal Reports from the past week on

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For TNF Response in RA, Weight Matters

Jul 22, 2020

Patients with rheumatoid arthritis (RA) who were obese were significantly less likely to remain on treatment with tumor necrosis factor (TNF) inhibitors -- but so were those who were underweight, a large, long-term study determined.

Compared with patients with normal weight, patients in obesity

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Bisphosphonate therapy may be protective against radiographic knee OA progression in early‐stage patients (KL grade < 2) (HR 0.53), especially non-obese. Study from 1977 women in the Osteoarthritis Initiative.

Dr. John Cush RheumNow ( View Tweet)

Jul 20, 2020
#EULAR2020 #op0192 UK Biobank and IMPALA studies: metabolic body composition of PsA pts w/increased VAT,ectopic liver fat distribution & ⬆️ abdominal fat index associated w/increased risk of CHD&T2DM @RheumNow
Olga Petryna DrPetryna ( View Tweet)
Jun 07, 2020
Dan Clauw: obese patients with chronic pain reported improved pain levels very early with low calorie diet, long before weight loss, suggesting the diet may be having a more direct effect.

Stefan Siebert StefanSiebert1 ( View Tweet)

Jun 06, 2020
Do certain TNFi get more affected by obesity in RA?
David Liew drdavidliew ( View Tweet)
Jun 05, 2020
Obesity is a strong predictor of worse clinical course and treatment response in AS. Poster #THU0389 #EULAR2020 @RheumNow
Dr. Rachel Tate uptoTate ( View Tweet)
Jun 05, 2020
This Turkish study found that obesity did NOT play a roll in tx efficacy/retention using SEC in axSpA patients. #EULAR2020 Poster #THU0390 @RheumNow
Dr. Rachel Tate uptoTate ( View Tweet)
Jun 05, 2020
Do you routinely discuss obesity with your rheum patients? #EULAR2020 @RheumNow

Dr. Rachel Tate uptoTate ( View Tweet)

Jun 05, 2020
Interesting observation: obese patients seem to respond better to etanercept than to mAb TNFi @RheumNow
Jun 05, 2020

Physical Activity Prevents Hospitalization

May 06, 2020

Modifiable lifestyle choices can impact long term health.  A recent study shows that usual and increased physical activity can results in less hospitalization amongst the the general population.

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Cigarette Smoking and ANCA-Associated Vasculitis

May 05, 2020

JAMA Internal Medicine has reported that cigarette smoking associated with an increased odds of having antineutrophil cytoplasmic antibody–associated vasculitis (AAV) (especially MPO positive AAV) and is thereby a modifiable risk factor for AAV.

In a case-control study, 473 AAV

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Lenabasum Encouraging in Systemic Sclerosis

Apr 30, 2020

The oral cannabinoid receptor type 2 (CB2) agonist lenabasum showed promising results for systemic sclerosis (SSc) in a phase II study.

At week 16, the American College of Rheumatology Combined Response Index in diffuse cutaneous Systemic Sclerosis (CRISS) increased to 0.33 among

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Lower Risk of Diabetes with Abatacept

Apr 20, 2020

 Patients with rheumatoid arthritis (RA) treated with abatacept (Orencia) had a lower risk of developing diabetes mellitus compared with those receiving certain tumor necrosis factor (TNF) inhibitors, a large cohort study suggested.

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The Immunologic Basis of Wellness in the COVID-19 Era

Apr 06, 2020

We indeed are living in interesting times and we all are seeking not to contract COVID-19 - this is logical. While our goal is to avoid infection, I think we all must agree that our aspirations must encompass more than disease avoidance. What we should be seeking now, as well, is more than

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RheumNow Podcast- Methotrexate Mechanisms (2.28.20)

Feb 28, 2020

Dr Jack Cush Reviews the news and journal articles from the past week on

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Bariatric Surgery Improves Rheumatoid Activity

Feb 25, 2020

Obesity is a risk factor for the onset of rheumatoid arthritis (RA) and may also an impediment to optimal DMARD and biologic responses.  A new study has shown that after 1 year, obese RA patients undergoing bariatric surgery with weight loss had significantly lower disease activity.

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RheumNow Podcast- Best Biologics (2.7.20)

Feb 07, 2020

Dr Jack Cush reviews the news and journal articles from the past week on

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Bariatric Weight Loss Fails to Alter RA Risk

Feb 06, 2020

Obesity has been shown to be a risk factor for the onset of rheumatoid arthritis (RA) and also shown to affect outcomes by impairing responses to many DMARD therapies. A Swiss study of RA patients undergoing bariatric surgery failed to show that bariatric surgery and weight loss had any effect

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RheumNow Podcast- A Good First Impression (1.24.20)

Jan 24, 2020

Dr Jack Cush comments on this week's journal articles, reviews and studies.

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Diabetics using SGLT2 Inhibitors have a lower Gout Risk

Jan 14, 2020

Researchers from the Brigham and Women's Hospital have reported that adults with type 2 diabetes who were treated with SGLT2 inhibitors had a lower risk of gout compared to GLP1 agonist, suggesting that sodium–glucose cotransporter-2 inhibitors may reduce the risk for gout with type 2 diabetes

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Obesity Not Discussed by Doctors and Patients

Dec 17, 2019

Reuters -  Doctors rarely talk about weight concerns with patients who are overweight or obese, and when they do, patients’ experiences tend to be negative, according to a new review of research based on interviews.

Most often, doctors avoid the topic, leaving patients feeling

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FDA Warns 15 CBD Manufacturers

Dec 06, 2019

Today, the U.S. Food and Drug Administration issued warning letters to 15 companies for illegally selling products containing cannabidiol (CBD) in ways that violate the Federal Food, Drug, and Cosmetic Act (FD&C Act).  This warning affirms that the FDA has not determined the many

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RheumNow Podcast – The Shoes Maketh the Doctor (10.25.19)

Oct 25, 2019

Dr. Jack Cush reviews the news and journal articles from the past week on

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