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Rare Diseases

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Methotrexate Monitoring (5.13.2022)

May 13, 2022

Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow.com. Bad news for digitial ulcers in Systemic sclerosis, Readmissions in Lupus and Thrombocytopenia in APL patients.




  1. Risk factors for readmission among 132,400 #SLE hospitalizatiions included

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Wiki Guidelines Approach to Pyogenic Osteomyelitis

May 12, 2022

A crowd sourced, WikiGuidelines approach to clinical treatment guideline development for pyogenic osteomyelitis yielded 7 important clinical questions, 2 clear treatment recommendations and 5 topic reviews to inform future treatment or investigations.



Some clinical scenarios may be

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Arthritis Predicts Hepatic Fibrosis in Hemochromatosis

Apr 25, 2022

Mayo Clinic Proceedings reports the results of a retrospective, cross-sectional of patients with HFE hemochromatosis showing that advanced hepatic fibrosis is primarily seen in those with arthritis due to HFE hemochromatosis. 



A total of 112 patients with a liver biopsy confirmed

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Is Alzheimer's Risk Lower With TNF Inhibitors?

MedPage Today
Apr 11, 2022

Tumor necrosis factor (TNF) inhibitors for rheumatoid arthritis were linked with a lower risk of Alzheimer's disease and related dementia, but only in people with cardiovascular disease, data from the DREAM (Drug Repurposing for Effective Alzheimer's Medicines) study showed.



Among

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RheumNow Podcast – What You Do For & What You Do To the Patient (4.8.2022)

Apr 08, 2022

Dr. Jack Cush reviews the news and journal articles from the past week and discusses the use of fibroscan in RA, steroid hip injections in OA and famous quotes from a famous cardiologist.




  1. CorEvitas Registry study of173 Axial #PsA pts showed 6 mos of bDMARD/tsDMARD resulted

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Consequences of TNF inhibition (3.18.2022)

Mar 18, 2022

This week we're going to talk about the downside of TNF inhibitors, a few interesting observations in gout, and yes, kids do get COVID. We're also going to preview what's coming in April (hint: it's about PsA). This and more as Dr. Jack Cush reviews the news and journal articles from the past

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Seropositivity Linked to Bronchiectasis in Rheumatoid Arthritis

Mar 17, 2022

Rheumatoid arthritis associated bronchiectasis (RA-BR) is uncommon, and is unrelated to interstitial lung disease (ILD), but like ILD, can substantially impact RA outcomes.



A case-control study from the Mass General Brigham Biobank compared RA-BR (57 cases) and RA controls without RA-

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Efficacy and Safety of Mavrilimumab in Giant Cell Arteritis

Mar 14, 2022

A phase II trial in patients with active giant cell arteritis shows that mavrilimumab, a monoclonal antibody against granulocyte-macrophage colony-stimulating factor [GM-CSF]) is capable of inducing clinical remission.

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RheumNow Live is Coming to Town (3.11.2022)

Mar 11, 2022

Dr. Jack Cush reviews the news and journal articles from the past week on RheumNow.com.

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Could Anifrolumab Work in Lupus Nephritis?

Mar 10, 2022

Anifrolumab is effective and FDA approved for use in systemic lupus erythematosus (SLE); and now, a trial in lupus nephritis that almost shows benefit.



A phase II double-blinded study looked at the efficacy of anifrolumab active, biopsy-proven, Class III/IV lupus nephritis taking

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Kawasaki Disease Guideline from ACR and Vasculitis Foundation

ACR
Mar 09, 2022

The American College of Rheumatology (ACR), in partnership with the Vasculitis Foundation (VF), released a new guideline for the management of Kawasaki disease that addresses diagnostic issues relating to Kawasaki disease, the treatment of high-risk patients, and the management of

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ACR Guidelines for the Treatment of Systemic Juvenile Idiopathic Arthritis

Mar 03, 2022

The ACR has updated its clinical guidelines for the management of juvenile idiopathic arthritis (JIA), with this update focusing on oligoarthritis, TMJ arthritis, and systemic JIA (with and without macrophage activation syndrome); only the latter, systemic JIA recommendations are reported

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Diagnostic Delay in Axial Spondyloarthritis (2.25.2022)

Feb 25, 2022

Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow.com. This week, rheumatologic problems incited by respiratory infections, air pollution and how you live, now where you live.




  1. Diagnostic delay in axial spondyloarthritis? Systematic review

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ACR Addresses Racial Disparities in Lupus Trials

ACR
Feb 24, 2022

The American College of Rheumatology (ACR) is launching two new initiatives to reduce racial disparities in lupus clinical trials: Training to Increase Minority Enrollment in Lupus Clinical Trials with CommunitY Engagement (TIMELY) and new Continuing Medical Education (CME) targeted towards

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RheumNow Podcast - RWCS 2022 Roundup (2.19.2022)

Feb 21, 2022

Drs. Jack Cush and Artie Kavanaugh review the highlights of the RWCS (Rheumatology Winter Clinical Symposium) from Maui.


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Acardi-Goutietes syndrome type 2 (an interferon party) w mutation presenting as adults, looks like cerebral palsy. Pernio, cerebral calcifications. Dr. Susan Shenoi @RWCSmtg #RWCS2022 https://t.co/x8sF8uWXeU
Dr. John Cush @RheumNow( View Tweet )
Feb 19, 2022
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Predicting Treatment Response in Inflammatory Muscle Disorders

MedPage Today
Feb 17, 2022

Rheumatologists looking for clues to whether their patients with certain inflammatory myopathies will improve on immunosuppressive drugs may find them in a new study appearing in Arthritis Care & Research.



Presence of dermatomyositis-specific autoantibodies, shorter time between

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CV Risk Management in Rheumatic Disease Patients

Feb 15, 2022

The European League against Rheumatism (EULAR) has developed recommendations for cardiovascular risk (CVR) management in rheumatic disease patients based on literature review and expert consensus.



These recommendations are applicable to patients with gout, vasculitis, systemic

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Hand OA and Heroes in Rheumatology (2.11.2022)

Feb 11, 2022

Interesting reports this week about dementia, who gets hand OA and a great list of women Heroes and Pillars of Rheumatology. Tune in as Dr. Jack Cush reviews the news and journal articles from this past week in RheumNow.com.

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ACR Updates Clinical Guidance for Multisystem Inflammatory Syndrome in Children Associated With COVID

Feb 09, 2022

A Task Force from the ACR has provided an updated (version 3) guidance for the diagnosis and management of Multisystem Inflammatory Syndrome in Children (MIS-C), a COVID related condition characterized by fever, inflammation, and multiorgan dysfunction. The current guidance also applies to

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X-Linked Hypophophatemia - Survey Results

Feb 04, 2022

The July 2021 RheumNow “Live Vote” surveyed US and non-US rheumatologists on their knowledge and practices when dealing with the bone disorder, X-linked hypophosphatemia (XLH). Although rare, XLH can be a diagnostic consideration in patients with recurrent fractures, rickets, osteomalacia and

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An Ounce of Prevention (2.4.2022)

Feb 03, 2022

Dr. Jack Cush reviews the news and journal reports from this past week on RheumNow.com.  He discusses the GI side effects of IL-17 inhibitors, downstream revenues from rheumatology care and dietary prevention of gout. 

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Pediatric Rheumatology Workforce Shortages

Feb 03, 2022

Two recent analyses from the USA and Canada point to a significant unmet need with regard to pediatric rheumatologists.



The 2015 pediatric rheumatology workforce in the US was evaluated by the American College of Rheumatology, estimating the Pediatric rheumatology supply and demand

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ACR/EULAR 2022 Classification Criteria for EGPA

Feb 02, 2022

The 2022 ACR/EULAR revised classification criteria for eosinophilic granulomatosis with polyangiitis (EGPA) have been revised and validated for use in clinical research.



This international cohort of vasculitis and comparator cases were to develop and validate criteria based on 91

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ANCA, vasculitis, test

ACR/EULAR 2022 Classification Criteria for Microscopic Polyangiitis

Feb 02, 2022

The 2022 ACR/EULAR  classification criteria for microscopic polyangiitis (MPA) have been developed, validated and are now ready for use in clinical research.



An international cohort of patients with vasculitis or comparator diseases were recruited to first develop criteria and then

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