Recent News
Read ArticleDr. Jack Cush reviews the news and journal articles from the past week on RheumNow.com. Today’s reports suggest where to look for help, especially with regard to pain.
Intracellular vs extracellular Calcium Pyrophosphate Crystals in 134 pts - 108 w/ intracellular & 26 w/ extracellular CPP crystals. Having Acute/chronic CPP crystal arthritis - 97% had intracellular and 62 extracellular crystals (p<0.001). Arthritis more likely to be asso w/… https://t.co/oRVNKptLfx https://t.co/06oGP4EyVJ
Dr. John Cush @RheumNow ( View Tweet)
Upadacitinib safety across in RA, PsA, AS, atopic dermatitis >15000 Pt-Yrs exposure. Rates (per 100PYs) of Hzoster (1.6–3.6), NMSC (0–0.8) & incr CPK (4.4–7.9) higher w/ UPA vs comparators (RA, PsA); Deaths (0–0.8), SIE (0–3.9), MACE (0–0.4), VTE (<0.1–0.4), CA, malignancies… https://t.co/OoJ5OX7JyL https://t.co/vaMVFmldEB
Dr. John Cush @RheumNow ( View Tweet)
Risk of Uveitis with Spondyloarthritis
A retrospective registry study shows that uveitis may be seen in 10% with the diagnosis of axial spondyloarthritis (axSpA) but becomes more common (47%) over the next 30 years of disease. The good news is that biologic therapy can… https://t.co/96rRu77Tyl https://t.co/bGHnZ7lCIm
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Long Term Antibiotics Increase Risk of RA
JAMA has published a population-based retrospective cohort study showing a possible association between the long-term use of antibiotics and the risk of rheumatoid arthritis (RA).
https://t.co/U7lPvTSJWO https://t.co/MrUuP6crB7
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GI Abnormalities in Scleroderma
A prospective Scleroderma Cohort Study found that gastrointestinal tract (GIT) involvement was common and negatively impacted quality of life, physical function, and employment, but had no effect on mortality.
https://t.co/6jQvKz7nmm https://t.co/1IGPe6obyS
Dr. John Cush @RheumNow ( View Tweet)
ED Delays and Hip Fracture Mortality Risk
Waiting more than 4 hours in emergency care for treatment is linked to heightened risks of death and a longer hospital stay for hip fracture patients, reveals a single centre study, published online in Emergency Medicine Journal.… https://t.co/ZaIEkb7Lo5 https://t.co/P15DrXMbnj
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UK Biobank study of 391 481 individuals found that a high polygenic risk score (PRS) for Hidradenitis suppurativa (HS) was assoc w/ increased risk of incident coronary artery Dz, diabetes, High LDL/TG and CRP https://t.co/ZS4w4hooKB https://t.co/DUXoFHMBqR
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University cohort study of 673 adults w/ CLE or dermatomyositis finds that 32% take herbal supplements, esp in younger & Hispanic pts. 31% of DM experienced Dz onset or flare after supplements (vs 10% in CLE). Elderberry had highest risk of exacerbation https://t.co/BZluGYzr3t https://t.co/5zJD7AwwNK
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Leiden Early Arthritis Clinic study (2011-17) of 431 pts found when RA is Dx in <12 wks, treatment costs were lower in Seropositive & negative RA. If Dx after 12wks, costs 316% higher in seronegative and 19% higher is autoantibody-positive RA pts https://t.co/I8QqZxIChW. https://t.co/8CRpqRiscz
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A CATCH study of 2052 early RA (ERA) pts found high incidence of hypertension (26%) with the highest risk in older patients with traditional cardiovascular risk factors. Those without HTN, at enrolment, 24% developed HTN after median follow-upof 5 years. https://t.co/8MmU60MK8v https://t.co/LyxSssXKLo
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Screening to Prevent Multimorbidity in Rheumatic Patients
A population based screening program of patients with chronic inflammatory rheumatic diseases (IRD) demonstrates that systematic screening IRD patients for multimorbidity increased preventive interventions and reduced hospital admissions.
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Full read review of the interaction of innate immune and adaptive immune systems. https://t.co/gXHcLbydxx https://t.co/VFFHL1GpjU
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https://t.co/Yk8dKDdZie https://t.co/d14Mq2AxlI
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What happens when "...When the person you could have been meets the person you are becoming" - Seth Godin https://t.co/RJOqNJvxwJ https://t.co/eBUc8V0Wdi
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Cancer risk increased following, but not before, a systemic sclerosis diagnosis. From a dataset of 10.1 million individuals, 1588 Dx w/ SSc & 206 developed cancer. Most common mucocutaneous (4.5%), lung (2%) breast (2%). Cancer risk higher after the Dx of SSc (HR ~1.4)… https://t.co/9GNMOU28TQ https://t.co/czLEsXymIv
Dr. John Cush @RheumNow ( View Tweet)
Mindfulness in Managing Chronic Pain
JAMA reports that outpatient resource mindfulness-based interventions (MBIs) delivered via telehealth are effective in managing chronic pain amongst veterans.
https://t.co/ytSb03h0Fd https://t.co/vWKvYW9Udb
Dr. John Cush @RheumNow ( View Tweet)
Artificial Intelligence in Diagnosing Sacroiliac Inflammation in axSpA
A so-called deep learning artificial intelligence (AI) algorithm for analyzing MRI scans showed "acceptable" agreement with expert human readers for detecting sacroiliac joint (SIJ) inflammation in patients… https://t.co/nKbYF603ut https://t.co/Y5IzVIG2l3
Dr. John Cush @RheumNow ( View Tweet)
Intracellular vs extracellular Calcium Pyrophosphate Crystals in 134 pts - 108 w/ intracellular & 26 w/ extracellular CPP crystals. Having Acute/chronic CPP crystal arthritis - 97% had intracellular and 62 extracellular crystals (p<0.001). Arthritis more likely to be asso w/… https://t.co/LY32oLJQv3 https://t.co/jSm4dkBICF
Dr. John Cush @RheumNow ( View Tweet)
GI Abnormalities in Scleroderma
A prospective Scleroderma Cohort Study found that gastrointestinal tract (GIT) involvement was common and negatively impacted quality of life, physical function, and employment, but had no effect on mortality.
Mucosal Disruptions as Initiators of Rheumatoid Arthritis
The microbiome and mucosal disruptions are believed to play a role in autoimmunity, particularly rheumatoid arthritis (RA). This is linked to the "mucosal hypothesis" of RA. A recent review by Hollers, et al. discusses… https://t.co/79khnkajMy https://t.co/UvZWwJ3ERg
Dr. John Cush @RheumNow ( View Tweet)
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