Inflammatory Arthritis Spread by ATP and Neural Crosstalk
May 19, 2022
Recent News
Read ArticleA novel study from the Journal of Experimental Medicine suggests that a reflex neural signaling at sites of inflammation may lead to spread to other inflammatory sites via and ATP-mediated neural crosstalk. Such findings may be important in disorders like rheumatoid arthritis (RA) and may lead to future novel interventions for RA.
Biologic Persistence in Psoriatic Arthritis and Psoriasis
May 19, 2022
Two recent studies examined the durability and persistence of biologic agents in patients with psoriasis (PSO) and psoriatic arthritis (PsA) and while some differences were noted overall persistence was low 3 years later.
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Local cryotherapy in adjuvant-induced arthritis in rats given bid resulted in lower arthritis scores, structural damages, less vascular inflammation/endothelial activation (less mRNA CXCL-1, IL-6, IL-1β, leukocyte infiltration, lower IL-17A and OPG https://t.co/b4cAa9E4PJ https://t.co/vhwWoY8Ujw
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Dr. John Cush @RheumNow ( View Tweet)
May 19, 2022
RCT (WBC) whole body cryotherapy (-130C x 3 min; 6 WBC in 14 d) in 56 RA pts. Pain at 2 wks was signif better in WBC than controls (-2 vs -0.88 ; p=0.003) & remained lower x 12 weeks (w less pain meds); Dz activity & Function improved but not signif @wk 12 https://t.co/K7a7CQ7rGj https://t.co/a8QgiDeJS6
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Dr. John Cush @RheumNow ( View Tweet)
May 19, 2022
Many have quoted and shown this image of Ankylosing Spondylitis in a young military recruit at age 25, 35, 45, 50 & 51yrs. This may be the MOST used slide in rheum! It comes from the work of Toronto's Dr. Hugh Little, who sadly passed away at age 58 yrs. https://t.co/PGrwBEtrQd https://t.co/948G3SUHvV
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Dr. John Cush @RheumNow ( View Tweet)
May 19, 2022
Watch: Pregnancy Paradox: How Stopping Drugs Leads to Greater Harm
Uma Mahadevan, MD talks about the pregnancy paradox and how stopping medications in pregnancy to protect the fetus can actually lead to greater harm.https://t.co/HYO5BdjwzZ https://t.co/IGeZ3O8Dno
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Dr. John Cush @RheumNow ( View Tweet)
May 19, 2022
Large Granular Lymphocyte Leukemia rarely assoc w/ #RA. LGL accounts for 2-5% of lymphoprolif. disorders; often assoc w/ Autoimmune Dz (mostly RA). RA w/ LGL presents with leukopenia, anemia, splenomegaly, onset after mean 6 yrs of RA https://t.co/AIz2edHDXp https://t.co/DoHKm3KS7d
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Dr. John Cush @RheumNow ( View Tweet)
May 19, 2022
Relevance of Raynaud’s in Systemic Sclerosis
May 18, 2022
Raynaud’s phenomenon (RP) is integral to the diagnosis and management of systemic sclerosis (SSc) patients; a recent analysis suggests that RP should be characterized based on color change and the presence of other symptoms to know whether RP portends more serious manifestations.
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RNL 2022: Spondyloarthritis Spectrum
May 18, 2022
This RheumNow Live 2022 session features highlights from lectures on Spondyloarthritis.
- Microbiome in Spondyloathritis - Jose Scher, MD
- Axial Psoriatic Arthritis - Philip Mease, MD
- Juvenile Spondyloathritis - Pamela Weiss, MD
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Machine Learning helps predict RA relapse: data from KURAMA, 210 RA pts (150 achieved remission; 60 relapsed). Using clinical, lab and US findings, ML identified US findings in wrist and MTP predictors of relapse https://t.co/9rhctim4Mh https://t.co/iK3JudOMsC
Dr. John Cush @RheumNow ( View Tweet)
May 18, 2022
Interested in what we covered in the month of April? You can find all our PsA content at the link below. What was your biggest takeaway from our PsA All the Way campaign?https://t.co/s5duGwoWeo https://t.co/lTqBKBHg0g
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Dr. John Cush @RheumNow ( View Tweet)
May 18, 2022
Multimorbidity Burden in Rheumatoid Arthritis
Crowson and colleagues at the Mayo Clinic have shown that rheumatoid arthritis (RA) patients have a higher prevalence of multimorbidity with as many as 44 different morbidities of interest in RA.https://t.co/vgC1dCA7kZ https://t.co/fLOaa1PDGU
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Dr. John Cush @RheumNow ( View Tweet)
May 18, 2022
Rising Incidence of Systemic Lupus Erythematosus
Data from Olmstead county, MN over the past four decades shows that the incidence and prevalence of systemic lupus erythematosus (SLE) is increasing.https://t.co/LCDmVS5UVb https://t.co/f3z6BlURkj
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Dr. John Cush @RheumNow ( View Tweet)
May 18, 2022
The global axial spondyloarthritis (therapeutics) market was estimated to be at $1.87 Billion in 2021, and is expected to grow to $7.9 billion by 2032 https://t.co/P9TUUBoneM https://t.co/qfBdkvCdru
Links:
Dr. John Cush @RheumNow ( View Tweet)
May 18, 2022
Tuesday Night Rheumatology: Spondyloarthritis Spectrum https://t.co/4QW8dNGJQq
Dr. John Cush @RheumNow ( View Tweet)
May 17, 2022
@RheumNowNews has already taken a shot at this but let us try : HOW MANY RITUXIMAB pts do you have on EVUSHELD pre exposure prophylaxis for #COVID19 @CCalabreseDO @PaulSaxMD @philipcrobinson @JYazdanyMD @DrPujaMehta1 @jeffsparks @zach_wallace_md @alhkim
Leonard Calabrese @LCalabreseDO ( View Tweet)
May 17, 2022
And now the paper that no one can find even if they are looking for it. On the relationship between disease activity and glucocorticoid disease. https://t.co/aT8I0jwQOJ@rheum_covid @ARD_BMJ https://t.co/7ntGLPdypJ
The COVID-19 Global Rheumatology Alliance @rheum_covid ( View Tweet)
May 17, 2022
Dr. Robert Rosenberg, a founding physician of Arthritis and Rheumatism Associates, is retiring after 44 years effective 5/31/22. ARA extends our deepest gratitude and sincerest thanks for his decades of service and exceptional patient care. We wish him well in his retirement. https://t.co/mYQODUk5VY
Arth and Rheum Assoc @ARARheum ( View Tweet)
May 17, 2022
At a time when most American doctors have never seen measles, I think we should stop calling things morbilliform.
Adam Cifu @adamcifu ( View Tweet)
May 17, 2022
Differential diagnosis of dysphagia - when due to autoimmune dz is called Autoimmune neurogenic dysphagia - causes include inflammatory myopathies,inclusion body myositis, myasthenia gravis, Guillain–Barre, MS, NMO, paraneoplastic neuropathies https://t.co/oA0cPVJ5pJ https://t.co/58MyQwmxhL
Links:
Dr. John Cush @RheumNow ( View Tweet)
May 17, 2022
⭐️Ethics of placebo-controlled trials in PsA ➡️move toward active comparator designs. Need to use measures of deeper response (e.g., ACR 50, PASI100).
⭐️Assesing safety: LTE studies not adequate. Use of phase 4 studies or observational data but beware confounding by indication
Rheum Cat @rheum_cat ( View Tweet)
May 17, 2022
From the blog
Interactions of the gut microbiota in humans promote the release of a variety of metabolites with profound effects on human health and immune regulation.
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When balancing all these disease domains, individual phenotypes, and comorbidities, sometimes treatment decisions can feel like tossing a coin. Fortunately, numerous guidelines have been published to help us do better than tossing a coin…or do they?
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Podcasts
RNL 2022- Spondyloarthritis SpectrumMay 18, 2022
Methotrexate Monitoring (5.13.2022)May 13, 2022
RNL 2022 - Psoriatic Arthritis AdvancesMay 11, 2022- What Is JAKne (5.6.2022)May 06, 2022
Tuesday Night Rheumatology- RA - Improving Future TherapyMay 04, 2022
Therapeutic Updates
Expert Perspectives on the Pathophysiology of SLE
Sponsored by GSK US Medical Affairs
May 01, 2022
Dr. Anca Askanase, Professor of Medicine and Director of the Lupus Center, Division of Rheumatology, Columbia University, takes us through the pathophysiology of SLE as we understand it today.
Read PostThe Science Behind a JAK Inhibitor for the Treatment of Ankylosing Spondylitis(AS)
Sponsored by AbbVie Medical Affairs
May 01, 2022
Read for an overview of results from SELECT-AXIS 2, a clinical trial of oral upadacitinib vs. placebo in bDMARD-refractory AS patients.
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