Recent News
Read ArticleA systematic review of the effectiveness and safety of pharmacological treatments for adult-onset Still’s disease (AOSD) supports the use of either IL-1 or IL-6 inhibitors.
Cutoffs for Systemic Juvenile Arthritis Disease Activity Score
An international cohort of children with systemic Juvenile idiopathic arthritis (Still's disease) validated the systemic Juvenile Arthritis Disease Activity Score 10 (sJADAS10), a disease activity measure distinguish patients with inactive disease, minimal disease activity, moderate disease activity, and high disease activity.
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Featured BSR Abstracts
Dr. Jack Cush muses on the news, journal reports, FDA announcements and the 2024 BSR abstracts just released.
https://t.co/Km8alIyCIP https://t.co/8yYUldF0pw
Dr. John Cush @RheumNow ( View Tweet)
Lower Limb Muscle Mass Influences Osteoarthritis Risk
The Rotterdam study shows that weight-bearing recreational physical activity caused more incident knee osteoarthritis (KOA), but mainly when there was low muscle mass.
https://t.co/N6JnJJgXgY https://t.co/hL7fK0DPWJ
Dr. John Cush @RheumNow ( View Tweet)
Study of 187 Oligoarticular JIA pts - Remission was achieved w/ DMARDs in 65.8%; predictors of nonresponse (DMARD resistance) - Elevated CRP (> 1.1 mg/dL' OR 1.3) & and high JADAS-71 at Dx (> 15.8; OR 1.7) https://t.co/tuO7UsEfrL https://t.co/KGcdBtneQt
Dr. John Cush @RheumNow ( View Tweet)
French insurance claims study of 12071 #PsA pts on biologics (2015-2021) found total of 367 serious infections (3%; IR 1.7/100PY). SIR risk significantly lower for new users of etanercept (wHR 0.72) & ustekinumab (wHR 0.57) (vs ADA new users https://t.co/CutqoxA05e https://t.co/OUCUbrKnFF
Dr. John Cush @RheumNow ( View Tweet)
Long term F/U of T2T in BeST (early RA 153) & IMPROVED (UA 282) pts 12 & 20 yrs after, the majority of RA & UA pts were in DAS remission (91% LDAS, 68% remission), & w/ limited functional disability (mean HAQ 0.6-0.8). Xray progression was mild https://t.co/vcL8Mnv0Ty https://t.co/lPVbNipFng
Dr. John Cush @RheumNow ( View Tweet)
#BSR Analysis of 1,362 pts starting 1st JAKi before EMA warnings on JAKi (1/23) showed 28% prev failed ≥3 bDMARDs & 80% met ≥1 EMA JAKi risk criteria -that included 1) age ≥65 2) incr CV risk; 3) current/past smoker; 4) prior cancer https://t.co/U3IaswZUyy https://t.co/m43RDAbpwP
Dr. John Cush @RheumNow ( View Tweet)
Multiplicative Adverse Effects of Social Determinants of Health in Lupus Nephritis: A Meta-analysis and Systematic Review
A metanalysis shows that social determinants of health adversely impacts patients with lupus nephritis. Lupus nephritis is a significant complication of SLE, often with dramatic increases in morbid and mortal risks. Outcomes are likely to be augmented by social determinants of health, including socio-economic status, and social risk factors.
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Imaging-Only Diagnosis of Giant Cell Arteritis Is Feasible
Medpage Today
Positive findings with color Doppler ultrasound were enough to diagnose giant cell arteritis (GCA) accurately without need for confirmation with temporal artery biopsy (TAB), a prospective study indicated.
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Machine learning analysis of retrosp EHR data (3/20-9/22) on 2+ million showed COVID (5.3%) outcomes in #IMID pts not linked to DMARD or IMID Dx; but rather to age, unvaccinated, & comorbidities (Afib, CAD, CHF, CKD, COPD, CA, liver Dz) https://t.co/aMmJD5P9cc https://t.co/Yy9FuCvol4
Dr. John Cush @RheumNow ( View Tweet)
SLE Faculty Panel Q&A
https://t.co/2OWlhfmKaP https://t.co/jx6MPDtojS
Dr. John Cush @RheumNow ( View Tweet)
Complex Autoantibody Patterns in RA
https://t.co/WmaXmmP7dY https://t.co/4dFgFEZ84i
Dr. John Cush @RheumNow ( View Tweet)
NEJM: evolution of pyoderma gangrenosum skin lesions https://t.co/vsgQhsjY5q https://t.co/INrbTIc9kX
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Dr. John Cush @RheumNow ( View Tweet)
Systemic Inflammation and Mortality in RA-ILD
Analysis of the German RABBIT registry shows that systemic inflammation, more so than disease activity, strongly influences all-cause mortality in patients with RA-ILD.
https://t.co/Qjtg364Pv7 https://t.co/aTQxTcO6Yv
Dr. John Cush @RheumNow ( View Tweet)
In 530 #GCA pts, relapses seen in 46%; but severe relapse (ischemi/aortic events) in 3%. Severe GCA relapse pts more likely to be younger at Dx(P=0.02), w/ more limb claudication(< 0.0001), fewer GCA-related cranial Sxs (<0.0001); but not higher mortality https://t.co/k7wgU6oMcn https://t.co/BKOfGmZ27u
Dr. John Cush @RheumNow ( View Tweet)
FDA issued a drug safety warning linking thiopurine (AZA, 6MP) use in pregnancy & a rare risk of intrahepatic cholestasis of pregnancy (ICP). ICP has been reported in pts w/ CD, UC, or SLE; however thiopurines are not FDA approved for these Dx https://t.co/s37eRuAtQx
Dr. John Cush @RheumNow ( View Tweet)
Study of f 234 AAV pts. 85 (36%) developed diffuse alveolar haemorrhage. Independent predictors of DAH: 1) Age [OR=1.037); 2) PLT # [OR=0.996]; 3) ESR [OR=1.028]; 4) HgB [OR=0.978]; 5) hematuria [OR=3.77] https://t.co/shI8RPZgcv https://t.co/dmceGvUuyR
Dr. John Cush @RheumNow ( View Tweet)
Biomarker Predictors of Osteoarthritis
Science Advances has reported that Duke University researchers have validated a biomarkers of osteoarthritis that may be identified 2 years before the appearance of radiographic OA. S
https://t.co/z5Tg9pAgqO https://t.co/ltY4rEg9p3 https://t.co/AjCKaUW59X
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Dr. John Cush @RheumNow ( View Tweet)
Very late onset Lupus (>60) is less female, less arthritis/dz activity, lower dsDNA, C3, SSA, SSB and ANA but more Sjogrens & RA? Single clinic study of 845 SLE - jSLE (<18), aSLE (18-49), lSLE (50-60), and vlSLE (>60).vlSLE had lowest survival (20yrs) https://t.co/VwDSArDhrc https://t.co/3pSr0xSCKn
Dr. John Cush @RheumNow ( View Tweet)
“50% of pts with lupus nephritis are asymptomatic . You have to have a degree of kidney damage before you have proteinuria. Proteinuria does not correlate with intrarenal activity.” – Dr. A Fava #RNL2024 @rheumnow https://t.co/w6UktVozsj
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Dr. John Cush @RheumNow ( View Tweet)
From the blog
One of the first words I was taught by my parents was “chào”. In Vietnamese, you say chào and bow when you greet someone or when you leave as a sign of respect.
In my first blog about self-discovery, I detailed the burnout and why I left clinical practice. In this second blog of the trilogy, I wanted to share encounters with patients as I told them goodbye. While I received great advice when I started practice, no one ever talks about how hard it is to leave.
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Podcasts
Featured BSR Abstracts (5.3.2024)
SLE Faculty Panel Q&A
Tuesday Night Rheumatology- Mastering SLE
Current & Future Biomarkers in SLE - Dr. Andrea Fava
Therapeutic Updates
Approaches for slowing organ damage progression in lupus
Sponsored by GSK US Medical Affairs
Watch our videos featuring global rheumatology experts to learn about recent advances towards slowing organ damage progression in lupus. Discover how you can implement disease modification and remission treatment goals, alongside corticosteroid tapering and the earlier introduction of biologics, to help improve patient outcomes.
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