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Multi-ancestry analysis reveals novel genetic loci associated with Osteoarthritis

Dec 06, 2022

The first large multi-ancestry genetics study of osteoarthritis (OA) has found 10 novel OA-associated genetic loci, and results showed some of the OA-associated regions are robustly found in every population ancestry studied. 

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Familial Mediterranean Fever mimics Dr Baspinar et al. performed a large case-control study in Turkey to assess whether acute abdomen episodes which led to appendectomies could be misdiagnosed as appendicitis rather than FMF-associated serositis.#ACR22 https… https://t.co/fHgeoLjNOu
Dec 06, 2022
Hydroxychloroquine: Cumulative Doses and Thresholds Dr. Sheila Reyes ( @RHEUMarampa) discusses Abstracts 0982 and 0344 at #ACR22 Convergence.https://t.co/k33LUNnTmV https://t.co/AJSBdT4rJC
Dec 06, 2022
Spondyloarthritis: Novel Therapies, Diagnostic Dilemmas and Depression Dr. Lianne Gensler ( @lianegensler discusses the following abstracts presented at #ACR22. Abstracts 1597, 1598, 1599 (treatment) and 1613, 1609 and 1614 (diagnosis and outcomes)https://t.co/0wCxKyFM0u https://t.co/8vaZ1ZncjF
Dec 06, 2022
Comorbidities in Ankylosing Spondylitis Dr. Akhil Sood ( @AkhilSoodMD) discusses Abstract 1609 at #ACR22 Convergence. https://t.co/tX0gP3mYmW https://t.co/PYLpoczz08
Dec 06, 2022
Vaccines Work! Dr. Eric Dein ( @ericdeinmd) and Dr. Caoilfhionn Connolly discuss abstracts 2275 & 0797 at #ACR22 Convergence. https://t.co/xXcs5yQPSi https://t.co/1C4Cj9Ykei
Dec 06, 2022
Systematic review of MSK findings in patients with acute lymphoblastic leukemia finds 29 pts with peripheral arthritis (7), axial manifestations (17), and osteolytic lesions (21 pts) & Vertebral Fx (4) Hypercalcemia in 9 cases. https://t.co/DhCMMlMs7f https://t.co/HjjL4aF22a
Dec 06, 2022
Comparison of 227 Systemic Sclerosis pts w/ & without ILD shows SSc-ILD to have more muscle Dz [OR 2.55], LVDD [OR 2.36], PAH [OR 9.13], dcSSc [OR 2.86], PLR [OR 1.005], elevated KL-6 [OR 2.03], and anti-Scl-70 [OR 3.1]. https://t.co/Pzx9N5rPcF https://t.co/F8mBQ1u5iL
Dec 06, 2022
Fat and bone are never alone: osteoporotic fracture in RA Dr. David Liew ( @drdavidliew) discusses Abstract 889 at #ACR22. Abstract 889: Serum Adipokines Predict Incident Osteoporotic Fracture in Patients with Rheumatoid Arthritis https://t.co/jSFmOiQb6N https://t.co/JTXugoxofP
Dec 06, 2022
Gender Differences in axSpA In abstract 1614, Dr. Poddubnyy presents the results of the PROOF study which assessed the probability of achieving inactive disease or low disease activity among males and females who were recently diagnosed with axSpA. https://t.co/DL2TDgXJnG https://t.co/XSQxWWnQgD
Dec 06, 2022
Lupus Linked With Greater Risk of Cardiovascular Complications of Childbirth Pregnant women with SLE were more prone to cardiovascular complications during delivery, and their risk seems to have increased over the past 15 years, according to data. https://t.co/mRUOVrKbt2 https://t.co/m18DWxSV20
Dec 06, 2022
Retrospective study of US National Inpatient Sample data 2015-2019 looked at 60,360 gout admissions, roughly 1/4 had Arrhythmias (mostly older pts; AFib (88%), atr flutter (6.2%), VTach (3.2%). Gout-arrhythmia pts had more deaths (adj OR 2.06) https://t.co/L1WEsybI7h https://t.co/xwAfFVJOuk
Dec 06, 2022
In pts undergoing hip or knee arthroplasty for OA, aspirin (3.45%) compared with enoxaparin (1.82%) resulted in a significantly higher rate of symptomatic VTE within 90 days, defined as below- or above-knee DVT or pulmonary embolism https://t.co/7hgLbynNx6 https://t.co/HMc4UbMcdy
Dec 06, 2022
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TARGET Trial - Cardiovascular Risk Reduction in Rheumatoid Arthritis

Dec 05, 2022

A recent randomised clinical trial suggests immunomodulators reduce arterial inflammation, and thereby cardiovascular (CV) risk, but shows no significant benefit to TNF inhibitors over triple therapy in patients with rheumatoid arthritis (RA).

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Comparing Biosimilar Growth in the US, Germany, and Switzerland

Dec 05, 2022

The biosimilar landscape will change dramatically in 2023, following the successful rollouts in other countries in Europe. This analysis of the uptake and price of biologic therapy in Germany, Switzerland and the United States suggest that anticompetitive practices in the US could allow biosimilars to enter the market sooner and could also lower health care costs with improved access.

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RA-ILD takes centre stage Greg McDermott presented abstract 2248 on the prevalence and mortality of subpleural interstitial lung abnormalities (ILA) in RA and non-RA comparators. https://t.co/zrg7IEhBfg https://t.co/dKACCzr4CZ
Dec 05, 2022
More Than a Conference:Life’s Lessons By: @KDAO2011 This is my 20th year attending the ACR meeting; despite my virtual attendance, I was still able to connect w/people. I reflected on my experiences w/ the conference and wanted to share my life lessons. https… https://t.co/9gBbaYBujc
Dec 05, 2022
MTX side effects more prominent in PsA than RA pts. Study of 240 PsA & 86108 RA pts starting either MTX or TNFi. TNFi AE same betw PsA & RA, but MTX adverse greater in PsA (44.8% vs. 29.4%), especially N/V, abdominal pain, depression, tinnitus https://t.co/0QBc6sb900 https://t.co/FZibAeFDBx
Dec 05, 2022
Sleep Quality & PsA Abstract #0387 presented at #ACR22 attempted to shed light in this important quality of life determinant. 247 adult PsA patients were included in this study and their sleep quality was measured using the PSQI questionnaire. https://t.co/lLTnrh2yxG https://t.co/9ViEnEFE6c
Dec 05, 2022
Humira biosimilars became available in EU 10/18; and will soon be available in the USA w/ Amjevita (Amgen) available Jan 2023 & 6 others (Pfizer, BI, Samsung, Coherus, Sandoz, Biocon) after July 2023. https://t.co/LH3MpT0o9O https://t.co/VeCbcdq5Ie
Dec 05, 2022
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