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  • May 17, 2022
    Malar,rash,SLE, Lupus

    Data from Olmstead county, MN over the past four decades shows that the incidence and prevalence of systemic lupus erythematosus (SLE) is increasing.

    SLE was diagnosed using the EULAR/ACR criteria and looked at patients seen between 1976–2018.

    They identified a total of 188 incident SLE cases in 1976–2018 (mean age 46.3 yrs; 83% women).

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morbidity,covid,heart,lung,brain

Multimorbidity Burden in Rheumatoid Arthritis

May 17, 2022

Crowson and colleagues at the Mayo Clinic have shown that rheumatoid arthritis (RA) patients have a higher prevalence of multimorbidity with as many as 44 different morbidities of interest in RA.

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Tuesday Night Rheumatology: Spondyloarthritis Spectrum https://t.co/4QW8dNGJQq

Dr. John Cush @RheumNow (  View Tweet)

May 17, 2022
@RheumNowNews has already taken a shot at this but let us try : HOW MANY RITUXIMAB pts do you have on EVUSHELD pre exposure prophylaxis for #COVID19 @CCalabreseDO @PaulSaxMD @philipcrobinson @JYazdanyMD @DrPujaMehta1 @jeffsparks @zach_wallace_md @alhkim

Leonard Calabrese @LCalabreseDO (  View Tweet)

May 17, 2022
And now the paper that no one can find even if they are looking for it. On the relationship between disease activity and glucocorticoid disease. https://t.co/aT8I0jwQOJ@rheum_covid @ARD_BMJ https://t.co/7ntGLPdypJ
The COVID-19 Global Rheumatology Alliance @rheum_covid (  View Tweet)
May 17, 2022
Dr. Robert Rosenberg, a founding physician of Arthritis and Rheumatism Associates, is retiring after 44 years effective 5/31/22. ARA extends our deepest gratitude and sincerest thanks for his decades of service and exceptional patient care. We wish him well in his retirement. https://t.co/mYQODUk5VY
Arth and Rheum Assoc @ARARheum (  View Tweet)
May 17, 2022
At a time when most American doctors have never seen measles, I think we should stop calling things morbilliform.

Adam Cifu @adamcifu (  View Tweet)

May 17, 2022
Differential diagnosis of dysphagia - when due to autoimmune dz is called Autoimmune neurogenic dysphagia - causes include inflammatory myopathies,inclusion body myositis, myasthenia gravis, Guillain–Barre, MS, NMO, paraneoplastic neuropathies https://t.co/oA0cPVJ5pJ https://t.co/58MyQwmxhL
Dr. John Cush @RheumNow (  View Tweet)
May 17, 2022
⭐️Ethics of placebo-controlled trials in PsA ➡️move toward active comparator designs. Need to use measures of deeper response (e.g., ACR 50, PASI100). ⭐️Assesing safety: LTE studies not adequate. Use of phase 4 studies or observational data but beware confounding by indication

Rheum Cat @rheum_cat (  View Tweet)

May 17, 2022
SARS-CoV-2-infected alveoli (specifically N protein-coding plasmid alone) induces IL-6 production. Also, COVID-19 Sera also induced IL-6, moreso in those w/ severe disease. anti-N Ab promotes IL-6 production & may lead to cytokine storm https://t.co/jfPNwZM0g8 https://t.co/FwIs11i2qc
Dr. John Cush @RheumNow (  View Tweet)
May 17, 2022
Tonight!: Join us for Tuesday Night Rheumatology on Spondyloarthritis Spectrum. This webinar will feature lecture highlights followed by live audience Q & A. 7pm ET | Join on Zoom or watch LIVE on RheumNow Twitter, LinkedIn and Facebook.https://t.co/Y6MtCItIxw https://t.co/ysRM3cWyYa
Dr. John Cush @RheumNow (  View Tweet)
May 17, 2022
Data from Scleroderma Lung Study (CTX vs MMF in PSS) shows that early progression of ILD by CXR scoring (≥ 2% at 12 or 24 months) experienced significantly worse long-term survival than those with stable Xrays (P = .014). https://t.co/BVy0WEE6G8 https://t.co/e6NN7nxNDt
Dr. John Cush @RheumNow (  View Tweet)
May 17, 2022
24 week, Phase II RCT of baricitinib in 314 active #SLE patients showed significant reductions in levels of dsDNA, IgG, Sm & ACL Abs; but had no effect on C3/C4, RNP, SSA, SSB. Changes in dsDNA did not correlate with SRI-4 responses though.https://t.co/cF6rHbtvf9 https://t.co/zXnUImaLHF
Dr. John Cush @RheumNow (  View Tweet)
May 17, 2022
lumbar,spine,lbp,pain

Acute Inflammatory Responses Needed to Resolve Chronic Pain

May 16, 2022

Science Translational Medicine has published results of a Canadian study of low back pain (LBP) suggests that pain control by anti-inflammatory treatments might have negative effects on pain duration and may be counterproductive for long-term pain outcomes.

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FDA.Safety.jpg

Bimekizumab Development Delayed by FDA

May 16, 2022

UCB announced they have received a Complete Response Letter (CRL) from the U.S. Food and Drug Administration (FDA) regarding the Biologics License Application (BLA) for bimekizumab for the treatment of adults with moderate to severe plaque psoriasis (PSO).

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FDA has approved baricitinib (Olumiant) for the Treatment of Certain Hospitalized Patients with COVID-19 who require supplemental O2, mechanical ventilation, ECMO. Rec dose: 4-mg once daily for 14 days or until hospital discharge https://t.co/RiEp01tc0v https://t.co/f3RvUAzdRp
Dr. John Cush @RheumNow (  View Tweet)
May 16, 2022
Cool NEJM Case of Spinal Gout in 82-yr-old woman with 3-wk hx of severe LBP, rigors, anorexia, incomplete urination. Hx of PsA, CKD, CHF treated w/ Humira, HCQ, diuretics. Imaging tophi in spine, responded to steroids and allopurinol. https://t.co/JgH2bPsDeu https://t.co/RAPNxohe55
Dr. John Cush @RheumNow (  View Tweet)
May 16, 2022
New podcast available on Methotrexate Monitoring. Download wherever you get your podcasts. Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow.https://t.co/TQiUMdS4R0 https://t.co/vgejiV3hUl
Dr. John Cush @RheumNow (  View Tweet)
May 16, 2022
Study of 198 RMD pts, vaccinated 91% JAKi and 80% MTX mono pts were Ab+ for spike protein. Adjusting MTX or JAKi did not significantly alter the immunogenicity (S1 spike Abs). DMARD adjustments w/ COVID-19 VAX may not be needed. https://t.co/ebw172M5I4 https://t.co/vjXqTbuD5t
Dr. John Cush @RheumNow (  View Tweet)
May 16, 2022
ASCORE: Seropositivity Favors Abatacept Drug Survival The ASCORE study evaluated efficacy, safety, and drug retention (durability) of ABA in moderate-to-severe RA and found consistently better ABA durability in those who were seropositive. https://t.co/dLFC3dW4Tv https://t.co/LNCUIQjnGf
Dr. John Cush @RheumNow (  View Tweet)
May 16, 2022
Can You Reduce Frequency of Methotrexate Monitoring?https://t.co/TnXZVCTv10 https://t.co/4q8sWwQ5aC
Dr. John Cush @RheumNow (  View Tweet)
May 16, 2022
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