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Consensus on Managing Vertebral Fractures in Advanced CKD

EurekAlert!

A coalition of leading international experts have released the first comprehensive Consensus Statement on the Management of Vertebral Fractures in Chronic Kidney Disease (CKD) Stages G4–G5D.

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APPIPRA Study - Benefits of Early Treatment

EurekAlert!

Treating people who are at high risk of rheumatoid arthritis (RA) can delay the onset of the disease for several years, with benefits also continuing well after treatment has stopped.

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Emergency Department Visits by Rheumatoid Patients

Jack Cush, MD

A Canadian population study shows that rheumatoid arthritis (RA) patients have 30% higher emergency department (ED) visit rates for Ambulatory Care Sensitive Conditions (ACSCs) compared to age- and sex-matched population controls.

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Smartphones and Rheumatoid Flares

Jack Cush, MD

FORWARD Databank of Rheumatoid arthritis (RA) patients reveals that smartphone data can predict flares using PROs. 

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2025

The 2025 Rheumatology Year in Review

Jack Cush, MD

The year 2025 presented numerous advances in rheumatology and related inflammatory and autoimmune disorders ranging from several new groundbreaking FDA approvals/indications, drug developments, game-changing guidelines and practices that will impact patient care for rheumatic diseases.

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APR Rheum and Inflammation Testing Cover

Rheumatoid & Inflammation Testing

Jack Cush, MD

Master the dos and don'ts of ordering RF, CCP (ACPA), and inflammatory markers that could transform your diagnostic accuracy.

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Air pollution ups ANA+: Ontariio Canadi study of 3548 serum samples (2010-13) corrlated particulate matter (PM2.5) w/ serologies. Highest vs lowest quartile PM2.5 showed higher risk of ANA ≥1:640 (OR 1.46) & ≥1:1280 (OR 1.54). Pollution has systemic immune effects! https://t.co/fJrhypNE2A
Dr. John Cush RheumNow ( View Tweet)
Testing for RF, CCP, ESR and CRP Check out the accompanying Advanced Practice Rheum: Rheumatoid and Inflammation Testing video. https://t.co/4hkDO1M2UD https://t.co/APRKYLAS3k

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Dr. John Cush RheumNow ( View Tweet)
Minnesota Mayo clinic retrospective, population study of RF & CCP in 1373 incident RA pts. At Dx, 37% dual seropositive, 13% +CCP only, 12% +RF only, & 38% seronegative. zDual seropositives had more erosions (31%) & flares (69% vs 51%). But +RF only highest mortality (adj 2.18) https://t.co/hPQewVgPoq
Dr. John Cush RheumNow ( View Tweet)
Testing for RF, CCP, ESR and CRP Check out the accompanying Advanced Practice Rheum: Rheumatoid and Inflammation Testing video. https://t.co/o1sle6CKg5 https://t.co/roYXcbPdBh

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Dr. John Cush RheumNow ( View Tweet)
Evaluation of pts w/ muscle weakness and elevated muscle enzymes https://t.co/faTWMscUzz https://t.co/Dcx8m4Ny7Y

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Dr. John Cush RheumNow ( View Tweet)
Smartphones and Rheumatoid Flares FORWARD Databank of Rheumatoid arthritis (RA) patients reveals that smartphone data can predict flares using PROs. https://t.co/xy6uqsQNt2 https://t.co/JwZlOLco6V

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Dr. John Cush RheumNow ( View Tweet)
Evaluation of pts w/ muscle weakness and elevated muscle enzymes https://t.co/1Yn3OXXEH6 https://t.co/qsTr4U1xV7

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Dr. John Cush RheumNow ( View Tweet)
Drugs that may cause toxic myopathy, presenting as muscle dysfunction w/ weakness and elevated muscle enzymes and possibly confused w/ idiopathic inflammatory myopathies (IIM) - full read review of mimickers of myositis. https://t.co/3wdLvkxcAX https://t.co/OqLjv45HXH

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Dr. John Cush RheumNow ( View Tweet)
ANAs and Autoantibodies https://t.co/PTdXPMCqjP https://t.co/Pbtgaod3uW

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Dr. John Cush RheumNow ( View Tweet)
FIBROSCANS in 60 RA pts on #MTX for 5 yrs w/ liver studies. Mean age = 39.5yrs, w/ Dz Dur 8.2 yrs, mean BMI 24.4 & MTX 12.5–25 mg for ~8 yrs (cum dose 6728mg). All had normal AST, ALT, APRI, Abd US; fibroscan score = 170 ((steatosis grade 0). Only 4(6.7 %) had mild, fibrosis https://t.co/7SACsEYi37
Dr. John Cush RheumNow ( View Tweet)
Rheumatoid & Inflammation Testing https://t.co/tEkJWGp7DK https://t.co/ZO4BV2mmhn

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Dr. John Cush RheumNow ( View Tweet)
PNAS/Yale researchers report on a mice model of RA, MIF-dependent, CD74+ memory T cells (normally very few) expand & incr in number in the inflammed joint. When MIF genes were deleted in a CIA model, arthritis was prevented. MIF-dependent, CD74+ T cells promote chronic synovitis. https://t.co/pdPIqtSCwG
Dr. John Cush RheumNow ( View Tweet)
FIBROSCANS in 60 RA pts on #MTX for 5 yrs w/ liver studies. Mean age = 39.5yrs, w/ Dz Dur 8.2 yrs, mean BMI 24.4 & MTX 12.5–25 mg for ~8 yrs (cum dose 6728mg). All had normal AST, ALT, APRI, Abd US; fibroscan score = 170 ((steatosis grade 0). Only 4(6.7 %) had mild, fibrosis https://t.co/OOctcfI1sT
Dr. John Cush RheumNow ( View Tweet)
Anti-mitochondrial M2 Ab (AMA-M2) in 987 IIM pts-- 55 (6%) were AMA-M2 positive. AMA-M2+ had signif. higher rates of polymyositis (56% vs 23.5%), GGT, alk phos levels, & 3 fold more cardiac involvement (60 vs 13%) (arrhythmias, CHF, pulm HTN (31-56%), but no effect on survival https://t.co/8fQzgRfHr4
Dr. John Cush RheumNow ( View Tweet)
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