Sporadic reports of anakinra use in COVID-19 infection has hinted is potential; now a metanalysis shows that the use of anakinra may reduce the mortality risk in patients admitted to hospital with moderate to severe COVID-19 pneumonia, especially highly elevated ferritin and C-reactive prote
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Despite spending more (18%) of its gross national product on health care than its peers, the U.S.
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For organ transplant recipients, a third dose of Moderna's COVID-19 vaccine more than tripled the proportion with a sufficient antibody response, a randomized trial showed.
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A new European real world experience study shows that mepolizumab is effective at both 100 or 300mg every 4 weeks in patients with the rarely encountered eosinophilic granulomatosis with polyangiitis (EGPA; or Churg-Strauss Syndrome).
https://t.co/VBxg9fQmt0
Sporadic reports of anakinra use in COVID-19 infection has hinted is potential; now a metanalysis shows that the use of anakinra may reduce the mortality risk in patients admitted to hospital with moderate to severe COVID-19 pneumonia... https://t.co/XIB7OVNCvT
Efficacy and safety of tildrakizumab in patients with active psoriatic arthritis: results of a randomised, double-blind, placebo-controlled, multiple-dose, 52-week phase IIb study https://t.co/XVXgEoufCw Nice data another p19 IL23 inhb - safety continues to impress
New study data on mRNA vaccines in pts with inflammatory diseases on mostly #TNFi +/- #csDMARDs .
▶️ Effective immune response (lower than healthy controls)
▶️Comparable side effects
▶️ no ⬆️ in DAS28
▶️ no pts on #Rituximab included
https://t.co/aexdFoUzer https://t.co/h1S1S2YsHS
Biomarkers predict early ILD in systemic sclerosis: https://t.co/9z4Swjjy4p we need a biomarker for early disease!
Chronologic Progression of Ankylosing Spondylitis
https://t.co/ihVVystOMn https://t.co/SXhkkBgzTJ
COVID Vaccine Booster Effective for Transplant Recipients in Small Trial
For organ transplant recipients, a third dose of Moderna's COVID-19 vaccine more than tripled the proportion with a sufficient antibody response, a randomized trial showed.
https://t.co/iD2WFfUP3a https://t.co/eYMdocd9T4
A new European real world experience study shows that mepolizumab is effective at both 100 or 300mg every 4 weeks in patients with the rarely encountered eosinophilic granulomatosis with polyangiitis (EGPA; or Churg-Strauss Syndrome).
https://t.co/hgeiSHhxSj https://t.co/cfi2nZGzBa
Symptom eval of 870 1st degree relatives of RA in PREVeNT-RA study - 5% were seropositive & 14% had incr CRP. Sleep probs (20%) & joint pain (18%) most common. Symmetrical small joint pain ~12% higher in RF+ and 11% higher w/ high CRP https://t.co/aYoLX0sZ2p
Interesting case report of difficult periorbital Discoid lupus erythematosus (DLE) treated with topical tofacitinib, 2%, ointment, a topical Janus kinase (JAK) 1/3 inhibitor. https://t.co/NZxUFW9ilN
Drs. Jack Cush, Kathryn Dao, Janet Pope, Eric Dein and Yuz Yusof discuss a number of lupus presentations as well as abstracts presented at the virtual EULAR 2021 meeting. Lupus nephritis and treat-to-remission presentations were discussed by the panel.
https://t.co/dfRdeveeLp
In 206 #SLE pts (mean 62 yrs) polypharmacy (≥10 meds) seen in 35%. 31% used benzodiazepines & 24% opioids. Polypharmacy greater with prednisone, comorbidity & rural. Polypharmacy assoc w/ 4X Benzo & 7X opioid use https://t.co/4U0UakoIRr
Takayasu's responds to Tofacitinib - 53 pts given TOF + glucocorticoids (GCs) (n=27) or MTX + GCs (n=26). At 12 mos complete remission (CR) more with TOF (88% vs 56%, p=0.02), w/ lower GC use and relapse rates ((12% vs 35%, p=0.052) https://t.co/qgziyIhKgV
Current Israel data for mRNA vaccination in people age >60, 1st to get vaccines >6 months ago, now confronting Delta infections
1. Vaccines work but their apparent effectiveness is diminished over time + Delta
2. Boosters showing some preliminary evidence of working
via @dvir_a https://t.co/YKgF9dlFz3
Ashish K. Jha, MD, MPH
Tweet
Today, the 5 most vaccinated states (14M people) had
580 people in hospital, 12 deaths
In the 5 least vaccinated states (16M people)?
6,600 hospitalized, 104 deaths
Per capita , least vaccinated states have
10X hospitalizations and 7X deaths
So yeah, vaccines are working
Nice rvw of tx for SSc-ILD by @sclerodermaUM et al
Endorse: "MMF is now considered the standard of care as first line
therapy for the treatment of SSc-ILD"
Reasonable chart, but wish we could offer more HSCT
Also, I'm seeing a LOT of INappropriate early use of nintedanib https://t.co/n1R73EbrXZ


