In Canada, biologic DMARDs (bDMARDs) were introduced after 2001, and since that time there have been significant reductions in hip and knee arthroplasty (THA/TKA) among patients with rheumatoid arthritis (RA), but not in patients with osteoarthritis (OA).
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The CDC had reported the Advisory Committee on Immunization Practices (ACIP) study of rare serious adverse events after COVID-19 vaccination and assert that the excessive morbidity and mortality from COVID-19 (and the protection afforded by vaccination) far exceeds the risk of rare safety signals
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A large cohort study of rheumatoid arthritis (RA) patients shows that regular tea consumption was associated with a lower risk of RA.
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The TORTUGA trial tested filgotinib, a JAK1 inhibitor, in active ankylosing spondylitis (AS) patients and was shown to be both effective and capable of retarding sacroiliac (SI) joint erosions as early as 12 weeks.
Smart, concise, insightful short video by Dr Marwan Bukhari (Editor-in-Chief of Rheumatology) on how to write an abstract. https://t.co/M8AUFZsxMF
The TORTUGA trial tested filgotinib, a JAK1 inhibitor, in active ankylosing spondylitis (AS) patients and was shown to be both effective and capable of retarding sacroiliac (SI) joint erosions as early as 12 weeks.
https://t.co/awfZdiTUBt https://t.co/ST2JIkavhy
TB rarely causes arthritis; accounts for 1-5% of all TB (10-30% of pulmonary TB) cases. May present as mono/oligoarthritis, tenosynovitis, dactylitis, Spondylitis (Potts disease), reactive arthritis (Poncets dz) or polyarthritis. https://t.co/RpMrRLQbEa
Safety and Tolerability of Subcutaneous Methotrexate
A large, single-rheum center analysis of oral and SC MTX use in daily clinical practice suggests that SC MTX has fewer drug discontinuations and is better tolerated compared to other DMARD therapies.
https://t.co/TZwZO9j5xd https://t.co/tx9dWoHUj0
It was a banner week at the FDA; a new drug approval you should know about; a lot of information about pregnancy and safety; and an interesting case plus a question from one of our readers--this and more in this week's podcast. Let's dive in.
https://t.co/5K8ejJ4jj2 https://t.co/RDEM0BMZLC
Lumbar Spine Decompression Alone is Superior to Decompression with Fusion
https://t.co/EjLoVZaJf5 https://t.co/OJHJl3EWsv
Can you manage FM without opioids? Study of 698 Fibromyalgia pts from a tertiary center finds 27.1% taking opioids. Opioid associated with longer Sx duration (>3 yrs), increased age, worse functional impairment & pain catastrophizing https://t.co/N1G4ZtkUE5
Delays in Joint Replacement as JIA Patients Reach Adulthood
https://t.co/EQNZPD8d7o
The JIA category, year of implant, and presence of complications significantly affected implant survivorship. https://t.co/yiD74AElPC
FDA issued Drug Safety Communication to statin manufacturers requesting they remove strong warnings against statin use during pregnancy. While statins appear in breast milk, they should not be contraindicated, if needed, during Pregnancy https://t.co/AeFwpsLMXT
Pfizer has another JAK inhibitor - ritlecitinib - shown to be effective (vs PBO) in alopecia areata in the Phase 2b/3 ALLEGRO trial. Ritlecitinib is also being studied in vitiligo, rheumatoid arthritis, Crohn’s & ulcerative colitis. https://t.co/ccx0eRXuTS https://t.co/fApTP7WaYU
IL-6 Inhibitor Safety Issues-Download now!
https://t.co/rjId76sJ64 https://t.co/QwBJNmrzBf
In a head to head trial Upadacitinib was superior to Dupilumab in Adults With Moderate-to-Severe Atopic Dermatitis. 24wk DBRCT, 924 pts given either UPA 30/d vsDUP 300 EOW. ESI75 response@wk16, UPA 71% vs DUP 61% https://t.co/5cOoosKyao
New podcast available for download!
https://t.co/5K8ejJ4jj2 https://t.co/Va66dLGrXO
ICYMI:
Skin Involvement with HMGCR Necrotizing Myositis
The Journal of Autoimmunity reports that anti-HMRCR antibody positive, necrotizing myositis patients frequently have cutaneous lesions, more so than previously reported.
https://t.co/RR07dYIJSr https://t.co/MiaIqvMPaB
ICYMI:
D-penicillamine Adverse events reported to FDA (1970-2020): dystonia (OR 20.52), drug hypersensitivity (OR 5.42), pancytopenia (OR 10.2), joint swelling (OR 9.07), Renal (OR 6.68), dysphagia (OR 5.05), CHF (OR 4.04), edema (OR: 3.77) https://t.co/8lmYiJo2Tz
ICYMI:
CRESS – A New Composite Measure for Primary Sjögren's Syndrome
https://t.co/7tvjBvP3g4


