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Mortality and Hospitalization with Pulmonary Hypertension in Systemic Sclerosis

d Jack Cush, MD

PHAROS is a prospective cohort studying the natural history of pulmonary hypertension (PH) in systemic sclerosis (SSc). They have shown that risk factors for poor outcomes in this cohort included male sex, DLCO < 50%, exercise oxygen desaturation, and pericardial effusions. 

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Noninfectious Proximal Aortitis Needs Serial Follow-ups

d Jack Cush, MD

A Cleveland Clinic review of patients undergoing thoracic aortic surgery (1996‐2012) identified 196 patients with histopathology‐proven non‐infectious aortitis.

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No Added Benefit to MRI-Guided Therapy in Rheumatoid Arthritis

d Jack Cush, MD

A treat-to-target (T2T) strategy to manage rheumatoid arthritis hinges on clinical metrics to optimize therapy. But investigators from Denmark have shown that using magnetic resonance imaging–guided T2T failed to improve disease activity remission rates or reduce radiographic progression.

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Differing Effects of Smoking and HLA-DRB1 in Seropositive Rheumatoids

d Jack Cush, MD

Analyses from the Swedish EIRA incident rheumatoid arthritis cohort study shows that smoking and HLA-DRB1 exert differential effects on serologically defined RA subsets - but that the strongest influence was seen in double positive (CCP+, RF+) individuals.

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SEAM-PsA Study - Does Monotherapy MTX Win Despite Losing to Etanercept in Psoriatic Arthritis?

d Jack Cush, MD

The SEAM-PsA study examined the efficacy of methotrexate monotherapy, etanercept monotherapy or the combination of MTX and ETN in psoriatic arthritis patients, and found that ETN monotherapy was equivalent to combination therapy - and that both were superior to MTX alone in clinical (ACR and MDA) and radiographic responses.

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RCT of 559 patients undergoing hip replacement shows that postoperative use of paracetamol plus ibuprofen or ibuprofen alone significantly reduced morphine consumption. https://t.co/JbnkvBzibC

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JBMR reports that women with single & multiple fractures (hip, spine, ribs) strongly negatively impacts the HRQL of older people over a prolonged period, and that they may not recover their prefracture QOL. https://t.co/1udPUiyCc0

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Small study of 25 pregnancies in RA compared those who continued biologics till conception vs those who stopped before conception. Continuing biologics till conception lead to a significantly shorter time to pregnancy. https://t.co/NjhMDbQVux

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Dr Anne Stevens at RWCS. Many dysregulated paths contribute to fibrosis in disease. #RWCS2019 https://t.co/dCXjoge0yL
Dr. John Cush RheumNow ( View Tweet)
Dr Anne Stevens at RWCS. Pathways to Fibrosis. #RWCS2019 https://t.co/gTYWWrxY81
Dr. John Cush RheumNow ( View Tweet)
Dr Paul Emery at RWCS. RA without xray erosions- 45% have ultrasound erosions #RWCS2019 https://t.co/MlOUaMTgfd
Dr. John Cush RheumNow ( View Tweet)
Dr Paul Emery at RWCS. #RWCS2019 https://t.co/MFqjLVzpDa
Dr. John Cush RheumNow ( View Tweet)
Dr Aretha Fischer on how to tx ILD. #RWCS2019 https://t.co/vZhX25NhFF
Dr. John Cush RheumNow ( View Tweet)
Dr Aretha Fischer on ILD. #RWCS2019 https://t.co/YAyXapxr8C
Dr. John Cush RheumNow ( View Tweet)
The Best Rheums go to the Best Meetings - RHEUMNOW LIVE - March 22-24 2019 Great Venue =Fort Worth. Short Lectures, interactive sessions, Q&A panels, TED (like) Talks, digital, streaming and much more. You dont want to miss this meeting! https://t.co/5TVg0Frsbf

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Genetic study using Mendelian randomization methods in a large UK biobank shows that whereas serum Uric acid has no association with eGFR level nor CKD risk, sUA does show a significant risk of #Gout. https://t.co/YRiVuOKof4

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Dr. John Cush RheumNow ( View Tweet)

In a mouse model of Pso/SpA/IBD the administration of IL-23 was associated with specific microbiome changes that correlated with disease activity https://t.co/wWjVNkvOfz

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Dr. John Cush RheumNow ( View Tweet)

To all Rheumatologists & others: T or F I am reasonably familiar with the entity-Clonal Heamatopoesis of Indeterminate Potential (CHIP) (getting ready for my Highlights of Basic & Clinical Immunology series! )@RheumNow @RheumatologyUK @join_IAS @autoimmunitymd @AutoimmuneList

Leonard Calabrese LCalabreseDO ( View Tweet)

Is the Serious infection (SIE) risk different between TCZ and TNFi? Not when used after failing 1 TNFi; But for biologic initiators, SIE risk was higher in TCZ compared to TNFi or ABA (based on claims data from 16074 TCZ matched to 33109 TNFi initiators https://t.co/kT9R04pBrz

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Dr. John Cush RheumNow ( View Tweet)

The CDC says the flu season is peaking and far from over. https://t.co/XUqNQk86Xz

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Dr. John Cush RheumNow ( View Tweet)

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