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Dr Jack Cush reviews the news and Journal reports and takes "Back Talk" questions from viewers.
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The American College of Rheumatology (ACR) today commended leaders in the United States Senate for introducing the bipartisan Safe Step Act of 2021 (S. 464), new legislation that would place reasonable limits on insurer use of step therapy.
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McInnes and colleagues have published the results of the SELECT - PsA trial in NEJM showing updacitinib (UPA) to be superior to placebo in active psoriatic arthritis (PsA) patients, with 15 mg UPA equal to adalimumab (ADA) and 30 mg UPA qd being superior to ADA.
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The European Journal of Preventive Cardiology reports that younger patients with their first myocardial infarction before age 50 yrs have a higher risk of having a systemic inflammatory disease (SIDs) and higher rates all-cause mortality.
Dr. John Cush
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Thanks @doctorRBC for sharing this from #RNL2021
"Dr. N Haroon talking about SpA treatment
-TNFi can reduce spinal radiographic progression
-Better to taper biologics in AxSpA than stopping
-JAKinibs are coming "
Dr. John Cush
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News Feature: HLA B27 Iritis - RNL 2021 Highlights by Dr. Rachel Tate ( @uptoTate ) #RNL2021 #RheumNow
https://t.co/SlftHnhD6z https://t.co/utjOU0rfBP
Dr. John Cush
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News Feature: Inflammatory Conditions Up the Risk of Premature Myocardial Infarction
https://t.co/gbPpAYJGFg https://t.co/ValdJWGyxl
Dr. John Cush
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News Feature: Aortic Calcification and Lumbar Fracture Risk in Older Men
https://t.co/6gcoP9EFey #RheumNow https://t.co/BTTrYAoyNp
Dr. John Cush
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In the UK, NICE has recommended Kineret (anakinra) for use as 1st line biologic Rx in systemic JIA and adult-onset still’s disease (AOSD); but pts must first fail a DMARD - the latter is unfortunate as systemic Sxs of Still's do not respond to usual DMARDs.https://t.co/BNdqhLy9jg
Dr. John Cush
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From @doctorRBC #RNL2021 coverage "Avoid the lawsuit... “warty” appearing skin lesions in a lupus can be confused as skin cancer on shave biopsy when in fact it could be VERRUCOUS LUPUS which can be treated with HCQ. Perform a deeper biopsy. - Dr. Clay Cockrell " #RheumNow
Dr. John Cush
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Comparison of oral and parenteral MTX shows oral MTX in RA is non inferior to subcutaneous MTX treatment (in 640 RA pts) with regard to disease activity, but oral MTX had fewer adverse events than SC ( 41% vs 52%, p= 0.005). https://t.co/828kcG53iz
Dr. John Cush
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Matched cohort Nurses’ Health Study looked at 283 pre‐RA pts (mean 9.7 years before RA Dx) and and 842 controls; 21% pre‐RA were ACPA+. ACPA+ was associated with increased risk of COPD (HR 3.04) that was not seen in ACPA- pts. https://t.co/HNB11eAiva
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Dr. Olga Petryna ( @drpetryna) weighing the future Rx in RA by Dr. Fleischmann:
-CD22, new IL6i & GM-CSF show promises but far form being available
-bDMARD or tsDMARD after MTX but work better wMTX
-JAKS better choice for mono-therapy but safety is a concern
#RNL2021
Dr. John Cush
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#RNL2021 coverage from @doctorRBC
ACR’s conditional recommendations for tx of specific RA populations #RheumNow https://t.co/3uo9x42bPX
Dr. John Cush
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Retrospective study of 267 adults w/ Henoch-Schönlein purpura (AKA IgA vasculitis (IgAV) shows more arthritis, enteritis & renal Dz, higher comorbidity scores (2.6 vs1.5) & higher risk of Serious infx (OR 8.4) and death (MRR 2.06) than gen population https://t.co/ihK6JPbLFm
Dr. John Cush
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News Feature: Hypertension Unaffected by Urate Lowering Therapy
Does uric acid contribute to the risk of hypertension (HTN)? A recent cohort trial shows that allopurinol in young adults does not sufficiently lower blood pressure (BP).
https://t.co/PAMkgCc2DS #RheumNow https://t.co/ar7OiWKVQj
Dr. John Cush
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263 RA patients with ILD were treated w/ Abatacept (ABA mono, ABA+MTX or ABA+nonMTX) - all improved their DAS28, stablized their FVC, DLCO, CHest CT; Only difference was that steroid sparing best when ABA used in combo. https://t.co/11vJCWOdSG https://t.co/yMF6imuFMV
Dr. John Cush
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Abstract presented 10/20 at American Society Nephrology mtg show IV Pegloticase use in 136 ESRD dialysis pts (Rx by Rheums 68%). Pts were 73% males, avg age 57 years, More on hemodialysis [79%] than peritoneal dialysis [17%]. Pts RCV ~13 infusions. https://t.co/SFO8duqiy8
Dr. John Cush
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Great coverage of #RNL2021 from Dr. Robert Chao @doctorRBC
Fascinating talk by Dr. Robert Wang on uveitis. Pearls:
-Anterior uveitis with hypopyon, will be B27+
-Hypopyon can be 2/2 Behcets and endopthalmitis
-work up for Uveitis: B27, ACE/CXR, syphilis test
#RNL2021 https://t.co/9DdNaAt7lx
Dr. John Cush
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News Feature: Psoriatic Disease Management - #RNL2021 Highlights
This year’s coverage of psoriatic arthritis included an overview of the latest therapeutic options, a discussion on psoriasis specifically, and the epidemiology of psoriatic arthritis.
https://t.co/wJ0pFgANhy https://t.co/SJezq1O7T4
