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No Link Between Autoimmune Diseases and Monoclonal Gammopathy of Undetermined Significance

Jack Cush, MD May 21, 2024

Annals of Internal Medicine reports a study of more than 75,000 persons screened for monoclonal gammopathy of undetermined significance (MGUS) and found no association between autoimmune rheumatic disease (AIRD) and MGUS.

There's a huge difference between knowing the name of something and knowing something. We talk in fact-deficient, obfuscating generalities to cover up our lack of understanding.

Do you have a rheumatology question or case for Dr. Cush? Record it here and we may feature it on an upcoming podcast. Tell us your name and where you practice rheumatology. https://t.co/qvVEUoNYi5 https://t.co/duw6jg5xpp

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No Link Between Autoimmune Diseases and Monoclonal Gammopathy of Undetermined Significance Annals of Internal Medicine reports a study of more than 75,000 persons screened for MGUS and found no association between AIRD and MGUS. https://t.co/F8diWbUYPf https://t.co/M53Dgphcge

No Link Between Autoimmune Diseases and Monoclonal Gammopathy of Undetermined S…

Lille Univ Hosp study of 485 systemic sclerosis pts, found osteoporosis in 23% (18% w/ fragility Fx). OP independently linked to age (OR1.06), topoisomerase I Ab+ positivity (OR 2.22) & GC treatment (OR 4.48) https://t.co/9KN5VQnl4A https://t.co/L7RwDdzaFZ

Osteoporosis is associated with anti-topoisomerase I positivity and glucocortic…

Consensus Statements on Vitamin D The “Controversies in Vitamin D” International Conference has published their proceedings on vitamin D metabolism, assessment, actions, and supplementation. https://t.co/QGXbJdJpAC https://t.co/N1UkTi6u8C

Consensus Statements on Vitamin D | RheumNow

Alot of murky "research" on Platelet-rich plasma (PRP). This RCT of120 pts having anterior cruciate ligament reconstruction (half randomized to PRP) shows no PRP benefit, no significant improvement of knee symptoms & function post ACLR https://t.co/AwkCAq1QFb https://t.co/YP0hJd7soc

Intra-Articular Platelet-Rich Injection After ACL Reconstruction

K Kuhn et al: Altered tryptophan catabolism by microbiome may contribute to inflammatory arthritis. Tryptophan increases indole leading to ncreases in serum IL-6, TNF, and IL-1β; splenic RORγt+CD4+ T cells, & IL-23 and IL-17 production https://t.co/i9le12QZm2 https://t.co/akeXxWnQ9o

Microbiota-dependent indole production stimulates the development of collagen-i…

Infectious Mortality in ARD Infectious conditions are a significant cause of mortality in ARD. Among patients hospitalized with an infection, we compared in-hospital and long-term (3-year) mortality between those with and without ARD. https://t.co/p4n5Los89F https://t.co/vUBLC9TDDG

Infectious Mortality in Autoimmune Rheumatic Disorders | RheumNow

Save the date! We’ll be covering #EULAR24! https://t.co/HGjP2SFyOp

NEJM: evolution of pyoderma gangrenosum skin lesions https://t.co/wE9pAZZs9L https://t.co/jTijcCvpfI

https://buff.ly/3UKy8BA

JAMA Case: Scurvy in a 3 yr old w/ Gingival Hemorrhage and Musculoskeletal Pain. limp and increased bilateral limb weakness with inability to bear weight. Diet: mostly chicken nuggets and milk https://t.co/e3kpEXNl3K https://t.co/D4u56I0PSq

A 3-Year-Old With Gingival Hemorrhage and Musculoskeletal Pain

NEJM: evolution of pyoderma gangrenosum skin lesions https://t.co/vsgQhsjY5q https://t.co/INrbTIc9kX

https://buff.ly/4bq8ZCH

In 530 #GCA pts, relapses seen in 46%; but severe relapse (ischemi/aortic events) in 3%. Severe GCA relapse pts more likely to be younger at Dx(P=0.02), w/ more limb claudication(< 0.0001), fewer GCA-related cranial Sxs (<0.0001); but not higher mortality https://t.co/k7wgU6oMcn https://t.co/BKOfGmZ27u

Frequency and characteristics of severe relapses in giant cell arteritis

Biomarker Predictors of Osteoarthritis Science Advances has reported that Duke University researchers have validated a biomarkers of osteoarthritis that may be identified 2 years before the appearance of radiographic OA. S https://t.co/z5Tg9pAgqO https://t.co/ltY4rEg9p3 https://t.co/AjCKaUW59X

Full-read Overview of Macrophage Activation Syndrome - a rare complication of autoimmune inflammatory rheumatic dz; assoc w/ Still’s disease SLE, Kawasaki, dermatomyositis, RA, Sjögren’s. Precipitating factors, including genetics & infections reviewed https://t.co/LmL3BPmo6c https://t.co/OkfwpzNLAL

Frontiers | Heterogeneity of macrophage activation syndrome and treatment progr…

🏆Dr. Georg Schett's pioneering work in CAR-T for #autoimmune disease has landed him among the TIME100 Most Influential People in Health “Not only are the patients in drug-free remission, but I believe many are cured of their autoimmune disease," he said https://t.co/Rj7FpkluNg

Georg Schett

Articular Findings Sarcoidosis: - Acute arthritis: Lg Jt Oligoarthritis; Loffgrens syndrome (hilar LN, arthritis, E. nodosum) - Acute > Chronic arthritis - Chronic arthritis: tenosynovitis, oligo- &polyarthritis, dactylitis, erosions or Jaccouds arthritis

Prospective look at 25 280 older adults (mean 74yrs) w/ incident fracture, shows impact of multimorbidity by Charlson Comorbid Index (CCI). If CCI =2-3, Incr risk of subseq Fx (16-25%) & death (HR ~2); If CCI=4+, Fx Risk ^33-48%, death HR~4. https://t.co/6wnhFNiSXH https://t.co/Xy2y0ANDRd

Health Perceptions, Multimorbidity, and New Fractures and Mortality After a Fra…

Prevalence of MSK presentations in practice = 21.1%, based on UK practice cohort. Most common: pain in LS spine (18%) & knee (17%). Re-presentations of existing Dx made up 74% all MSK consultations. Steroid injx given to 1/3 of knee consults https://t.co/nTioq1lCEB https://t.co/ecm8Kxz2cu

The prevalence of musculoskeletal presentations in general practice: an epidemi…

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No Link Between Autoimmune Diseases and Monoclonal Gammopathy of Undetermined Significance

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