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Complex Autoantibody Patterns in RA

d EurekAlert!

Patients with rheumatoid arthritis (RA) all have a unique and diverse set of antibodies that are involved in the development of the disease.

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Systemic Inflammation and Mortality in RA-ILD

d Jack Cush, MD

Analysis of the German RABBIT registry shows that systemic inflammation, more so than disease activity, strongly influences all-cause mortality in patients with rheumatoid arthritis and prevalent interstitial lung disease (RA-ILD).

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Biomarker Predictors of Osteoarthritis

d Jack Cush, MD

Science Advances has reported that Duke University researchers have validated a biomarkers of osteoarthritis that may be identified 2 years before the appearance of radiographic OA.

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ARCTIC Rewind: Can You Taper DMARDs with Remission?

d Jack Cush, MD

In an open-label, randomized, non-inferiority trial, rheumatoid arthritis patients in remission were subject to tapering of disease-modifying antirheumatic drugs (DMARDs), and while maintenance of remission was seen in some, many DMARD tapering patients did flare and were unable to maintain flare-free survival compared to those on stable conventional synthetic DMARDs.

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TLR Antagonist in Lupus

d Medpage Today

An investigational Toll-like receptor (TLR) antagonist was effective in reducing biomarkers and clinical symptoms of systemic lupus erythematosus (SLE) in a pilot trial, evidence that the innate immune system may hold the key to lupus pathophysiology.

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Danish registry study shows positive association between maternal autoimmune Dz & childhood cancer. AID assoc w/ all child CA (OR=1.25), ALL (1.52), Burkitts (2.69), CNS tumors (1.45). RA mothers AID had higher risk of all cancers (OR=2.1) https://t.co/EYHyHzOboc https://t.co/FNRrvySI8P

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Dr. John Cush RheumNow ( View Tweet)
Dr. Gabalawy: "How do you know what disease patients will develop in this preclinical autoimmunity state?" @drdavidkarp ""it's like when weeds pop up in a garden, it's random ...if ACPA Ab pops up, you might have RA, if it's dsDNA, maybe lupus."" #RNL2024 https://t.co/kDkDaDRP8X

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Dr. John Cush RheumNow ( View Tweet)

Low urinary IL16 levels at 12 months predicts kidney survival at 3 years better than proteinuria - @Andreafava @rheumnow #RNL2024 https://t.co/4GLmJQr46C

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Dr. John Cush RheumNow ( View Tweet)

Rheum Chapter Notes Dr. Jack Cush reviews this past week’s news and journal articles from https://t.co/V10S4oVFsv. https://t.co/m6pkmYeiAl https://t.co/3cr3KwV1CP

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Dr. John Cush RheumNow ( View Tweet)
UK Early Inflammatory Arthritis Audit of 20,060 RA pts (~12k on MTX; 5K csDMARD; ~2.5K no DMARD). Serious infections (SIE) hosp rate was 3.19/100PY, death 0.1/100PY. SIE risk incr w/ age, smoking, Hi DAS28 & HAQ. 1 unit DAS28, SI risk increased by 8% https://t.co/OrNh8oYE3y https://t.co/DqbeibNMbp

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Dr. John Cush RheumNow ( View Tweet)
Tuesday Night Rheumatology: Mastering SLE https://t.co/lhExjSsKNA

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Dr. John Cush RheumNow ( View Tweet)

FDA issued a drug safety warning linking thiopurine (AZA, 6MP) use in pregnancy & a rare risk of intrahepatic cholestasis of pregnancy (ICP). ICP has been reported in pts w/ CD, UC, or SLE; however thiopurines are not FDA approved for these Dx https://t.co/XKoUdy4sAR https://t.co/DSU9z0v7CZ

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Dr. John Cush RheumNow ( View Tweet)
British Society for Rheumatology (BSR) presented (at the 2024 annual BSR meeting) new guidelines for the management of Behçet's disease - how to manage skin lesions, mouth ulcers, genital ulcers, serious eye, CNS & vascular involvement https://t.co/d0bjKuubym https://t.co/lqoTeTGqZ7

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Dr. John Cush RheumNow ( View Tweet)
Spondyloarthritis Faculty Panel Q&A Spondyloarthritis Faculty Panel Q&A - featuring Drs. Eric Ruderman, Lihi Eder, and Lianne Gensler; moderated by Dr. Artie Kavanaugh https://t.co/6RFkyO72e1 https://t.co/CJ174sETFv

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Dr. John Cush RheumNow ( View Tweet)
Future Therapy of Axial Spondyloarthritis https://t.co/wjrlkuu0ds https://t.co/jQ12eTpT2l

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Dr. John Cush RheumNow ( View Tweet)
Predicting Infection in Lupus Nephritis Machine learning (ML) models were applied to 3 cohorts of lupus nephritis (LN) patients and established algorithms to predict co-infection in LN. https://t.co/BnV7jVfqj1 https://t.co/LYQd6w1DvD

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Dr. John Cush RheumNow ( View Tweet)
Our final TNR for the month of April will take place on 4/30 at 6:30pm ET. Mastering SLE Rethinking Pre-Clinical Disease in Lupus - David Karp, MD Biology and Rx of Lupus Flares - Michelle Kahlenberg, MD Current/Future Biomarkers in SLE - Andrea Fava, MD https://t.co/j05QmWg17f https://t.co/jDvP0iTS8T

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Dr. John Cush RheumNow ( View Tweet)
Predicting CKD Outcomes in Lupus Nephritis An observational cohort study suggests that proteinuria levels in lupus nephritis (LN) patients did not predict their histologic class. https://t.co/UHNqj6WTXn https://t.co/IOc0Gv21FM

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Dr. John Cush RheumNow ( View Tweet)
In biologic-naïve active PsA pts Rx w/ guselkumab & achieving enthesitis (ER) or dactylitis resolution (DR), had better PRO outcomes. GUS - ER or DR was assoc w/ minimal pain (p < 0.001), normalized HAQ-DI (p < 0.001), , better FACIT-Fatigue responses https://t.co/HymI7CBfXh https://t.co/dYk9qXdVpt

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Dr. John Cush RheumNow ( View Tweet)
In 530 #GCA pts, relapses seen in 46%; but severe relapse (ischemi/aortic events) in 3%. Severe GCA relapse pts more likely to be younger at Dx(P=0.02), w/ more limb claudication(< 0.0001), fewer GCA-related cranial Sxs (<0.0001); but not higher mortality https://t.co/qyUpepmryA https://t.co/MJ9kAKl62r

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Dr. John Cush RheumNow ( View Tweet)

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