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Biomarker,genes

MRP8/14 as a Biomarker in Systemic Juvenile Idiopathic Arthritis

Jack Cush, MD

A large cohort study of children with febrile disorders has demonstrated the diagnostic utility of Myeloid-related protein 8/14 (MRP8/14) in diagnosing systemic JIA patients (SJIA) in clinical practice.

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Axial Spondyloarthritis

ICYMI: Update on Axial SpA at EULAR 2022

Antoni Chan, MD, PhD

This year at EULAR 2022, there were important and interesting topics in Axial Spondyloarthritis (AxSpA). These are my picks of abstracts from the conference.

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RheumNow Podcast square

Two Week Twitter (6.17.2022)

Jack Cush, MD

Dr. Jack Cush does a 2-week review of RheumNow Tweets on news and journal citations worth noting, along with some opinions on Telehealth, manpower, monkeypox and the price of drugs.

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hands pregnant

Improved Pregnancy Outcomes in SLE (2010–2020)

Jack Cush, MD

A retrospective cohort study has shown that outcomes in pregnant systemic lupus erythematosus (SLE) patients has significantly improved in the last decade, but there still is a high risk of adverse pregnancy outcomes (APO).

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Axial Spondyloarthritis

Update on Axial SpA at EULAR 2022

Antoni Chan, MD, PhD

This year at EULAR 2022, there were important and interesting topics in Axial Spondyloarthritis (AxSpA). These are my picks of abstracts from the conference.

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woman-1284353_640.jpg

Babies! Safety and Outcomes Data on Pregnancies

Kathryn H. Dao, M.D.

EULAR Congress 2022 highlighted several posters on pregnancy, an important subject as most rheumatic diseases afflicts women during their childbearing years.

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US national study of shows pregnancy in inflammatory bowel disease pts has higher risks for: - gestational diabetes (AOR) - HTN complications (1.35) - Pre-term births (1.41) - Fetal growth restriction (1.27) - Fetal death (3.21) https://t.co/3XTrrrNmoe https://t.co/udl7dXT5IF

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Dr. John Cush RheumNow ( View Tweet)
Babies! Safety and Outcomes Data on Pregnancies #EULAR2022 highlighted several posters on pregnancy, an important subject as most rheumatic diseases afflicts women during their childbearing years. I wanted to share with you the ones that caught my eye... https://t.co/piA1zhGyAA https://t.co/Kb68AGZgA1

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Dr. John Cush RheumNow ( View Tweet)
JAKi not yet safe in pregnancy - theyre fetotoxic at high doses (animals). JAKi do cross placenta. ACR Guidelines: no position due to no data. 47 tofa Rheum & 15 UC maternal exposures - no signif probs. Paternal use of JAKi is ok. https://t.co/PoIheshd2n https://t.co/gjTN2Uz4IP https://t.co/OAfLRvSFBs

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Dr. John Cush RheumNow ( View Tweet)
Watch this 4 minute video on Belimumab use in pregnancy featuring Dr. Kathryn Dao ( @KDAO2011 ) https://t.co/8uRUIVURHF https://t.co/lbYwHFFJit

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Dr. John Cush RheumNow ( View Tweet)
Babies! Safety and Outcomes Data on Pregnancies #EULAR2022 highlighted several posters on pregnancy, an important subject as most rheumatic diseases afflicts women during their childbearing years. I wanted to share with you the ones that caught my eye... https://t.co/ulQIo2gdlO https://t.co/dpoMd5Wbah

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Dr. John Cush RheumNow ( View Tweet)
Pregnancy data in SpA from 122 pts 40% flared during pregnancy, more frequent 2nd trimester, pts w/ axial dz 7 pts required start of TNFi during 2nd or 3rd trimester 40% post-partum @RheumNow #EULAR2022 ABST#POST0151 https://t.co/cdFRhRuCVH
Robert B Chao, MD doctorRBC ( View Tweet)
SpA pregnancies in #EULAR2022 POS1051 found that 40% of pts flared, particularly during their 2nd trimester in those with axial involvement OR post-partum. Seven flares led to TNFi initiation in 2nd or 3rd trimesters and were without correlation in post-partum flares. @RheumNow https://t.co/0ZWjYMwmzn
Dr. Rachel Tate uptoTate ( View Tweet)
WATCH: New 2022 ASAS/EULAR Recommendations on the Management of AxSpA Dr. Sophia Ramiro (Leiden University Medical Center) presents an overview of the new Spondyloarthritis treatment guidelines from ASAS/EULAR Task Force. #EULAR2022 https://t.co/AiCNQPm6KB https://t.co/kn4rmcbZrH

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Dr. John Cush RheumNow ( View Tweet)
Women with spondyloarthritis at increased risk of gestational diabetes, elective and emergency C-sections, and spontaneous pre-term birth. Infants were not more likely to be born SGA. @RheumNow #EULAR2022 ABST#OP0126 https://t.co/BTXQqruvPs
Robert B Chao, MD doctorRBC ( View Tweet)
Study of 2.9k offspring exposed to adalimumab, infliximab, golimumab during pregnancy, as compared to etanercept and certolizumab showed an adjusted hazard ratio for serious infections of 1.20 (CI 0.54, 2.64). @RheumNow #EULAR2022 ABST#OP0130

Robert B Chao, MD doctorRBC ( View Tweet)

Congenital malformations after intra-uterine exposure to non-TNFi when compared to certolizumab showed vedolizumab and belimumab were associated with higher CMs. Vedolizumab showed specific CM pattern (corpus collosum agenesis). @RheumNow #EULAR2022 ABST#OP0129 https://t.co/wgRlm9QLgW
Robert B Chao, MD doctorRBC ( View Tweet)
#POS0721 #EULAR2022 Are Aspirin + LMWH enough to prevent Adverse Pregnancy Outcomes (preterm, pregnancy loss, eclampsia) in High Risk Triple Antiphospholipid abs+ve + Low C3/C4? An Italian study of 128 patients said NO. Add Hydroxychloroquine @RheumNow https://t.co/927sZoHZEj
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
Flatman et al. Serious infections in babies born to women using TNFi during pregnancy. 2902 babies. Adjusted HR 1.20 (0.54-2.64) for agents with high vs low placental transfer. @RheumNow #EULAR2022 OP0130 https://t.co/oaW7wDPxva

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Richard Conway RichardPAConway ( View Tweet)

Hamroun @annamolto et al. Factors assoc with increased time to conception in SpA. 56 pregnancies. Multivariate model, age (HR 1.22 (1.08-1.40)) and preconception NSAID use (HR 3.01 (2.15-3.85)) assoc increase time to conception. @RheumNow #EULAR2022 OP0153 https://t.co/y2EAyAdRmk https://t.co/28aLimRInE

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Richard Conway RichardPAConway ( View Tweet)
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