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Pregnancy in vasculitis checklist: - goals and timeline - disease activity in 12 mos - is there end organ damage? - Review Rx - h/o clots/miscarriages, APLS? - Check Ro/La - Role for ASA? - Refer to MFM Catherine Sims #RNL2024 @RheumNow

Eric Dein ericdeinmd ( View Tweet)

How do vasculitis pts do during pregnancy? Variable due to different diagnoses of flares Gatto 2012: TA 3% flare, GPA 45% flare Fredi 2015: 35% flare Nguyen 2021: LVV 25% flare, 36% SVV -Catherine Sims #RNL2024 @RheumNow

Eric Dein ericdeinmd ( View Tweet)

2nd kidney biopsy in lupus nephritis have value. @andreafava #RNL2024 @RheumNow https://t.co/47J1CGQL81

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Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)
#RNL2024 day 2: - Vasculitis Pod with @anisha_dua and @philseo - STEP talks: @DrLisaCS on myositis malignancy screening, @EBRheum on ANCA myths, @RheumNow dead words in rheum - Spondy Pod with @JointMD @lihi_eder @LianneGensler

Eric Dein ericdeinmd ( View Tweet)

Proteinuria doesn’t correlate with internal activity in lupus nephritis , we really need better biomarkers. @andreafava #RNL2024 @RheumNow https://t.co/bFuxVnUCEB

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Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)
This is a crucial nuance. Men and women experience pain differently. The tendency to use that to then dismiss pain in women is entirely incorrect. @lihi_eder @RheumNow #RNL2024 https://t.co/X5QQsaIuNP

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Richard Conway RichardPAConway ( View Tweet)
Dr. Gabalawy: "How do you know what disease patients will develop in this preclinical autoimmunity state?" @drdavidkarp "it's like when weeds pop up in a garden, it's random ...if ACPA Ab pops up, you might have RA, if it's dsDNA, maybe lupus." #RNL2024 @RheumNow https://t.co/JmDtaTt3sU

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TheDaoIndex KDAO2011 ( View Tweet)
Great talk -this is a summary slide on lupus nephritis and biomarkers to predict renal survival. When you get a chance, you have to watch @andreafava on #RNL2024 https://t.co/3PgFWCU9n6 @RheumNow https://t.co/AZNq9XrTMx

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TheDaoIndex KDAO2011 ( View Tweet)
Combining results of urinary IL16, PR3, CD163 at 12 months best predicts kidney function protection at 3 years - @andreafava #RNL2024 @rheumnow https://t.co/0XV0MrhL1F

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TheDaoIndex KDAO2011 ( View Tweet)
Low urine IL-16 at 12 months predicted kidney survival much better than proteinuria. Check out AUCs in the this first slide. Dr. @andreafava reviews this potential biomarker. Question if this could also be a possible target for treatment as well? #RNL2024 @RheumNow https://t.co/cCLRERVXmq

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Dr. Rachel Tate uptoTate ( View Tweet)
Low urinary IL16 levels at 12 months predicts kidney suvial at 3 years better than proteinuria - @Andreafava @rheumnow #RNL2024 https://t.co/AEaL8n2nv8

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TheDaoIndex KDAO2011 ( View Tweet)
@andreafava @jhrheumatology Urinary biomarkers (CD163, IL-16) at 3 months predict the 1 year response better than UPCR - At 6 & 12 mos predicts renal survival at 3 yrs - At 12 mos: IL-16 92% accurate, sens 97%, Spec 80% vs UPCR 72% accurate, 75% sens, spec 67% #ACR2024 @RheumNow https://t.co/YtbCrwrch0

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Eric Dein ericdeinmd ( View Tweet)
Scary! A third of patient with lupus nephritis who are considered complete respondues continue to aaccrue progressive renal damage - @Andreafava @rheumnow #RNL2024 https://t.co/mhu3YoY3YV

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TheDaoIndex KDAO2011 ( View Tweet)
1/3 of lupus nephritis patient classified as "complete responders" continued to accrue progressive renal damage despite resolution of proteinuria over 1 year. Dr. @andreafava reviews GFR trajectories after renal bx at #RNL2024 @RheumNow https://t.co/nYJZWw9jUL

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Dr. Rachel Tate uptoTate ( View Tweet)
Myeloid and neutrophil degranulation is involved in disease activation of lupus nephritis. IL16 and CD163 are urinary biomarkers correlating with histologic disease activity “- Dr. @andreafava #RNL2024 @rheumnow https://t.co/YffIRy8B9u

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TheDaoIndex KDAO2011 ( View Tweet)
Urine proteomics in lupus nephritis IL-16 and CD163 are urinary biomarkers most correlated w/ histologic activity Myeloid & degranulation sign ass w histo activity -> PR3+cells abundant in LN @andreafava #RNL2024 @RheumNow https://t.co/AVkZxPXkw3

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Eric Dein ericdeinmd ( View Tweet)
@andreafava reviews options other than renal biopsy in the future of Lupus renal disease. Urine proteomics can detect LN active pathways IL-16, proinflammatory chemokine, linked to LN activity as potential new biomarker? #RNL2024 @RheumNow https://t.co/GoEwu09npd

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Dr. Rachel Tate uptoTate ( View Tweet)
Proteinuria does NOT correlate with intrarenal activity. Additionally, initial bx was not predictive of ESKD. Dr. Andrea Fava discusses need for second bx but difficulty doing so ie: it's invasive, it has risk, etc. #RNL2024 @RheumNow @andreafava https://t.co/1E5uuBGsO9

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Dr. Rachel Tate uptoTate ( View Tweet)
“90% of repeat biopsy will lead to change in treatment. Get the 2nd biopsy” – Dr. A Fava #RNL2024 @rheumnow https://t.co/wLaZelSeFo

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TheDaoIndex KDAO2011 ( View Tweet)
@andreafava: 57% of pts w/ lupus nephritis are asymptomatic Screen w/ proteinuria- but does NOT correlate w/ intrarenal disease - Cannot differentiate classes, lagging indicator, does not distinguish inflammation from damage 87% repeat Bx lead to change in Rx #RNL2024 @RheumNow https://t.co/de66VSKUG1

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Eric Dein ericdeinmd ( View Tweet)
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