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Increasing Polypharmacy and Drug Interactions in Seniors
Qato and colleagues have published in JAMA a cohort study that examined the use of both prescription and over-the-counter medications among older adults and the frequency of major drug-drug interactions. The study shows the elderly are especially at risk, and the situation is
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First Head-to-Head TNF Trial Ends in a Draw
Comparative efficacy trials may be the best way to make informed treatment choices in a sea of treatment options for rheumatoid arthritis (RA). Recent years have seen impressive head-to-head (H2H) clinical trials for RA, including AMPLE (abatacept vs.
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FDA Approves Taltz for Psoriasis
Tuesday the FDA approved the IL-17 inhibitor, Taltz (ixekizumab) for adults with moderate to severe plaque psoriasis. (Citation source http://buff.ly/1py10wd)
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Bisphosphonate Use Falls Following FDA Warnings
In the current issue of JBMR, Kim and colleagues from Brigham and Women's Hospital in Boston assessed US claims data and studied the impact of three FDA drug safety warnings regarding the use of bisphosphonates.
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Acetaminophen: No Effect in Osteoarthritis Pain or Function
A network analysis of multiple therapies used in osteoarthritis found that acetaminophen (paracetamol) does not meet the minimum standard of clinical effectiveness in reducing pain or improving physical function in patients with knee and hip osteoarthritis.
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Minimal Disease Activity Falls Short in Psoriatic Arthritis
A small cohort study has evaluated the utility of the minimal disease activity (MDA) criteria that has been advocated for use in psoriatic arthritis (PsA) studies and clinical trials.
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Ixekizumab Superior to Etanercept in Psoriasis
The UNCOVER-2 and UNCOVER-3 trials were presented at the American Academy of Dermatology (AAD) Annual Meeting taking this week in Washington, D.C.
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Vitamin D has No Effect on Knee Osteoarthritis
Vitamin D supplementation for individuals with knee osteoarthritis and low 25-hydroxyvitamin D levels did not reduce knee pain or slow cartilage loss, according to a study appearing in the March 8 issue of JAMA.
Intraarticular Steroids Before Joint Surgery Increase Infection Risk
Hip and knee intraarticular injection of corticosteroids are frequently prescribed to alleviate pain or inflammation in patients with osteoarthritis and rheumatoid arthritis, especially in the period leading up to scheduled arthroplasty.
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TNF Inhibition and Heart Failure
Clinicians often face the issue of using a TNF inhibitor (TNFi) in patients with heart failure or cardiac disease. Here are the facts and data necessary to make a cogent decision to use or avoid TNFi.
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Less Treatment, Responses and Safety in Elder-Onset Rheumatoid Arthritis
A recent review compared elderly-onset rheumatoid arthritis (EORA) to those with younger-onset rheumatoid arthritis (YORA) to assess treatment responses and safety issues with biologics and DMARDS. EORA is generally defined as the onset of rheumatoid arthritis after age 60 years.
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Subclinical Synovitis in Psoriasis Portends Future Psoriatic Arthritis
It is estimated that nearly 30% of psoriasis patients will develop psoriatic arthritis (PsA). This prevalence was studied by performing MRI scans on asymptomatic psoriasis (n=56) and 30 control patients without arthritis.
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Tools, Brains & Organizers for Your Phone
Most people can’t live without their cell phone. But does the device define the modern medicine man and woman?
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Rheumatoid Arthritis Alone is Not a Risk for Post-Op CV Events
Using hospitalization claims from 7 states, reasearchers studied the risk of cardiovascular outcomes following surgery in rheumatoid arthritis (RA) patients. (Citation source http://buff.ly/1TDsVG6)
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Oral Prednisolone and NSAIDs Equipotent in Acute Gout
An emergency department based study evaluated the efficacy and safety of oral prednisolone versus indomethacin in 416 patients with acute gout in a multicenter, double-blind, randomized trial.
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Febuxostat Safe in Gout with Moderate-Severe Renal Impairment
Renal impairment is a risk factor for gout and a barrier to optimal gout management. Many of the drugs used to treat gout require adjustment in those with renal disease.
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Pulmonary Hypertension Earlier and More Severe in Men with Scleroderma
Pulmonary hypertension is an uncommon complication of systemic sclerosis (SSc) and historically thought to slowly evolve in those with limited scleroderma over many years.
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Lupus Flares After Renal Transplant
Whether lupus activity is ameliorated by end-stage renal disease (ESRD) or transplantation has been debated.
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RWCS 2016 - Updates in AS, PsA and Lupus
Update on Ankylosing Spondylitis and Spondyloarthritis
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Smoking and Age Linked to Development of Inflammatory Arthritis
A prospective cohort of RA first-degree relatives were prospectively studied for genetic and environmental factors (smoking, body mass index, education, and parity) and RA-related autoantibodies that may influence future development of inflammatory joint symptoms over a 2 year 
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