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RheumNow Podcast – Bad Disease & Bad Outcomes (10.9.20)

Jack Cush, MD

Dr. Jack Cush Reviews the news and journal articles from the past week on RheumNow.com.

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RheumNow Podcast – Cardiovascular Risk in Psoriatic Disease (9.25.20)

Jack Cush, MD

Dr. Jack Cush reviews the news and Journal articles from the past week on RheumNow.com.

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EULAR Updated 2019 Recommendations for Psoriatic Arthritis Management

Jack Cush, MD

In June 2020, we failed to report on the ARD publication updating the 2019 update the European League Against Rheumatism (EULAR) recommendations for the pharmacological treatment of psoriatic arthritis (PsA) - these are presented below.

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RheumNow Podcast – Lupus Delights (9.18.20)

Jack Cush, MD

Dr Jack Cush reviews the news and journal reports from the past week on RheumNow.com:

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NSAIDs Shows No Advantage over CBT in Knee Osteoarthritis

Jack Cush, MD

JAMA Internal Medicine reports on a controlled clinical trial of knee osteoarthritis patients wherein meloxicam responses were not significantly or clinically superior to placebo or CBT (after placebo).

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Capsaicin Injection Improves Knee OA Pain

RheumNow

Highly purified synthetic trans-capsaicin (CNTX‐4975) injected directly into the joint reduced pain in chronic knee osteoarthritis (OA), data from the open-label phase III VICTORY-3 trial showed.

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RheumNow Podcast – To Celiac Test or Not? (9.4.20)

Jack Cush, MD

Dr Jack Cush reviews the news, journal articles and takes a few Back Talk questions this week:

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TSR Shoulder replacement

Durability of Total Shoulder Arthoplasty

Jack Cush, MD

A systematic review of the outcomes of total shoulder replacements (TSR), humeral hemiarthroplasties, and reverse total shoulder replacements finds that approximately 90% of shoulder replacements last for longer than 10 years with good patient-reported outcomes.

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Another case of COVID-19 Arthritis; 58 yoF w/ non-severe COVID-19, (by qRT-PCR ) had arthralgia, fever, cough, nausea, diarrhoea, dysgeusia, and devloped ankle arthritis CRP 7·36 mg/L, lymphopenia (1·29) persistent arthritis (by US) and +Sars-CoV-2 in SF. https://t.co/4Pg1Vq30EN

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Dr. John Cush RheumNow ( View Tweet)

Lockdown worsening; UK survey 678 patients musculoskeletal diseases pts in late April 2020 shows 53% worsening of Sx; 1/3 had clinic/hosp access probs problems & most (88%) had no probs w/ getting meds; but 44% needed others to help them get meds. https://t.co/3efmTdHhQx

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Dr. John Cush RheumNow ( View Tweet)

388 RA pts Rx w/ either b/tsDMARD (Group I) or csDMARD (Group II) . After 3 years, BMD stable at the femoral neck, hip and lumbar (L1–4) (P =0.09, 0.15, 0.87) in Group I, but . BMD decreased significantly in Group II (P=0.045, <0.001, 0.004) at these sites.https://t.co/BExfJ772Hu

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Dr. John Cush RheumNow ( View Tweet)

Small study compared denosumab (20 pts) and teriparatide (21) in glucocorticoid-induced osteoporosis (GIO) Pts not responding to bisphosphonates. At 24 mos Teriparatide might have some advantages over denosumab (greater increases in LS/fem neck BMD) https://t.co/5wR9DlLfPK

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Dr. John Cush RheumNow ( View Tweet)

Study of early axSpA from the DESIR cohort looked at MRIs of the SI joint/spine @baseline, 2 & 5 yrs; showed that bone marrow edema pn MRI‐SIJ and ‐spine at baseline predicted of ‐year damage pm MRI‐SIJ [OR=4.2] and MRI‐spine [OR=10.7] https://t.co/3PAJ5Zt4Pp

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Dr. John Cush RheumNow ( View Tweet)

Pain in Knee Osteoarthritis comes from what?

Dr. John Cush RheumNow ( View Tweet)

A machine-learning algorithm was developed using MRI data from the Osteoarthritis Initiative capable of predicting osteoarthritic progressors from baseline cartilage texture maps ; Had a test accuracy of 78% in detecting OA progression 3 y prior to Sxs https://t.co/OPw9KGb4jr

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Dr. John Cush RheumNow ( View Tweet)

4033 Dual-energy CT lesions from 27 pts (23 gout; 4 nonGout) shows definite MSU deposits in MTP1 & patella tendons (high density/volume, low DECT ratio) & non-gout lesions seen in larger jts (knee, midtarsal, talocrural) & tendons (Achilles, quadriceps) https://t.co/M1wK52a23C

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Dr. John Cush RheumNow ( View Tweet)

Metanalysis of 11 RCTs (1353 patients) shows that saline injections are as effective as corticosteroids, platelet-rich plasma and hyaluronic acid for hip osteoarthritis pain https://t.co/z7jhOSUwQU

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Dr. John Cush RheumNow ( View Tweet)

Finish DBRPCT study of 146 adults w/ arthroscopic partial meniscectomy (APM) for med meniscal tear shows no clinical benefit after 5 years; but those with APM had slight, nonsignificant increase in Xray knee osteoarthritis (vs sham control) https://t.co/SFRvBH7gNh

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Dr. John Cush RheumNow ( View Tweet)

Falls are common after total hip arthroplasty - Cohort of 108 individuals (age of 72.4 yrs) w/ total hip arthroplasty followed 12 mos. 23% had a FALL; half (56%) w/in 6–12 mos of surgery. https://t.co/UXeB3cMuMO

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Dr. John Cush RheumNow ( View Tweet)

Risk of atypical femur fracture increased with longer duration of bisphosphonate (BP) use (HR 8.86 for 3-5yr; HR 43 fo r>8Yr) and rapidly decreased after bisphosphonate discontinuation. HIgher w/ Asians, height, weight, Steroids. https://t.co/I7VT6e031i

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Dr. John Cush RheumNow ( View Tweet)

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