New Criteria for the Cryopyrinopathies (CAPS)

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The diagnosis of periodic fevers is unified by undiagnosed but recurrent fever. Unfortunately the diagnosis of these disorders is hampered by their infrequency, protean features and a lack of clear criteria. Even more problematic is knowing who should be tested and for which monogenic marker?

Infection Rates Stable in JIA With Anti-TNF Therapy

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Children with juvenile idiopathic arthritis (JIA) treated with biologic therapies were at no higher risk for hospitalized infections than those treated with methotrexate alone, But, higher rates were seen with anakinra in systemic JIA.

RheumNow Week in Review – 30 September 2016

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Three new FDA approvals, proteomics, cancer, infectious risk, nonadherence and disappointing clinical trial results covered in this RheumNow Week in Review.

Ilaris Gets FDA Approval for Rare Febrile Disorders

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Ilaris was previously approved for use in systemic JIA and CAPS. The FDA has expanded this to include TRAPS, Hyper-IgD and FMF based on clinical trials.

The RheumNow Week in Review – 9 September 2016

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Dr. Jack Cush reviews highlights from the past week on RheumNow.com, including IBD/TNFi and cancer risk, fracture nonunion, PMR worse in women, not treating asymptomatic hyperuricemia, and shingles followed by stroke.

Flares Portend Damage in Rheumatoid Arthritis - Time for a New Strategy?

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Disease flares are common in rheumatoid arthritis (RA), often causing patients to seek additional care, if not medication.

The frequency of flares varies amongst studies in different populations.  But the consequence of flares has only recently been studied.

NIH Discovers Otulipenia - New Infantile Autoinflammatory Disorder

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Researchers at the National Institutes of Health, led by Dr. Dan Kastner, have led the way in the discovery and understanding of numerous autoinflammatory diseases.

RheumNow Week in Review – 26 August 2016

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Dr. Jack Cush reviews news and journal reports from the past week on RheumNow.com.

Consensus Recommendations for Juvenile Dermatomyositis

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SHARE (Single Hub and Access point for pediatric Rheumatology in Europe) is a group established in 2012 to develop and optimize diagnostic and management regimens in Europe for children and young adults with rheumatic diseases.

EULAR: Guidance for Managing Lupus Pregnancy

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The European League Against Rheumatism (EULAR) has published comprehensive recommendations on reproductive health and family planning for women with systemic lupus erythematosus and/or antiphospholipid syndrome – conditions that largely affect women of childbearing age.

Canakinumab Yields Genetic and Disease Modifying Effects in TRAPS Patients

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Tumor necrosis factor (TNF) receptor-associated periodic syndrome (TRAPS) is an autosomal-dominant autoinflammatory disease resulting from mutations of the TNF super family receptor 1A (TNFRSF1A) gene.

Epigenetic Changes to Inflammasome Found in Autoinflammatory Syndromes

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The gene mutations underlying inflammasome activity have been well described, but there appears to be variable penetrance among patients with the same gene mutation, suggesting additional mechanisms may influence disease expression.

Sandoz Etanercept Biosimilar Voted for Approval by FDA Arthritis Advisory Committee

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The Food and Drug Administration’s Arthritis Advisory Committee (AAC) yesterday recommended that the Sandoz etanercept (Enbrel) biosimilar (GP-2015) be approved for use in the United States.

Lupus Patients Genomically Stratified to Explain Treatment Responses

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Systemic lupus is a clinically heterogeneous disorder, unified by requisite clinical features and exuberant humoral response to unknown triggers.  While the diagnosis is easy, the disease course and management can be complicated and challenging.  

EULAR 2016 Drug Safety Report

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The EULAR Annual European Congress of Rheumatology meeting was held in London from June 8-11, 2016 and was well attended by thousands. This year’s meeting had over 2,000 poster displays, and the EULAR 2016 Congress presented new recommendations on the management of rheumatoid arthritis, spondyloarthritis, and fibromyalgia.

Arthritis and Suicide Linked with Childhood Adversities

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Men and women with arthritis have nearly a two-fold higher prevalence of lifetime suicide attempts than those without arthritis, according to a recent study from the University of Toronto.

JIA Women at Risk of Heart Disease

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Women with a history of juvenile idiopathic arthritis (JIA) are more than twice as likely as those without this condition to be diagnosed with heart disease, according to the results of a new study.

FDA Will Review Opioid Analgesic Use and REMS Programs for Pediatric Pain Patients

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Amidst a stringent regulatory environment, and with the rising use and abuse of narcotics and increasing regulation limiting narcotic analgesic use, the FDA approved (August 2015) the use of extended-release oxycodone in children (11 to 16 years old) with severe, "around-the-clock" pain

RheumNow Week in Review - 15 April 2016

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Video recap of highlights from this week at RheumNow.com.

Lupus Patients Genomically Stratified to Explain Treatment Responses

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Systemic lupus is a clinically heterogeneous disorder, unified by requisite clinical features and exuberant humoral response to unknown triggers.  While the diagnosis is easy, the disease course and management can be complicated and challenging.