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CKD & Osteoporosis Rx Revisited (7.25.2025)

Jack Cush, MD

Dr. Jack Cush reviews the news, journal and FDA updates from this past week on RheumNow.com.

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Osteoporosis Drug May Lower Osteoarthritis Risk

Jack Cush, MD

A target trial emulation study using administrative claims suggests that romosozumab was associated with a lower risk of osteoarthritis than teriparatide among individuals with osteoporosis, particularly for knee osteoarthritis.

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Practical management of rheumatic immune-related adverse events with immune checkpoint inhibitors

Jack Cush, MD

Joint Bone Spine has published a full read review of the management of immune-related adverse events (irAEs) in patients receiving Immune checkpoint inhibitors (ICIs) for cancer.

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Subclinical Synovitis Among Psoriasis Patients

Jack Cush, MD

A systematic review shows that imaging can be used to detect subclinical synovitis among patients with psoriasis and may identify individuals at risk for future psoriatic arthritis.

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antibody (Keep)

Clinical Associations with Anti-RNA Polymerase III Antibodies

Jack Cush, MD

A systematic review of anti-RNA polymerase III antibodies (ARA) in systemic sclerosis (SSc) patients finds ARA positivity in only 9% of SSc patients, but come with a higher risk of many potentially worrisome outcomes.

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Lung,AI,Pleura

RA Lung Disease Portends Poor Outcomes

Jack Cush, MD

A retrospective Harvard affiliates study shows that rheumatoid arthritis (RA) patients with lung disease have higher mortality, especially respiratory and infection-related mortality than those without lung disease (LD).

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Pesticides and Rheumatoid Arthritis?

MedPage Today

Women exposed to pesticides through farm work or as farmers' wives face increased risk for developing rheumatoid arthritis, a new analysis of Agricultural Health Study data indicated.

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NHANES, Numbers, & Risk (7.18.2025)

Jack Cush, MD

Dr. Jack Cush reviews the news and journal reports from this past week on RheumNow.com along with interesting case questions from "Ask Cush Anything".

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Zasocitinib (Tyk2 Inhibitor) Efficacy in Psoriatic Arthritis

Jack Cush, MD

A highly selective, tyrosine kinase 2 inhibitor zasocitinib (TAK-279), was studied in a phase 2b trial and found to be effective and safe patients with active psoriatic arthritis (PsA).

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Americans choose short term relief for neck and back pain

EurekAlert!

New survey data from the Orlando Health Spine Center reveals a significant difference among Americans on how to manage neck and back pain.

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DNA,genotyping,gene,sequencing

Molecular profiling of RA synovium predicts biologic responses

Jack Cush, MD

Machine learning analysis of pre-treatment synovial tissue biopsy from rheumatoid arthritis (RA) patients starting either etanercept (ETN), tocilizumab (TCZ) and rituximab (RTX) revealed

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Osteoporosis Drug May Lower Osteoarthritis Risk A target trial emulation study using administrative claims suggests that romosozumab was associated with a lower risk of osteoarthritis than teriparatide among individuals with osteoporosis, particularly for knee osteoarthritis. https://t.co/fWWw2t2jzR
Dr. John Cush RheumNow ( View Tweet)
If severe refractory SLE is defined as SLEDAI-2K≥10 despite steroids & immunosuppressives; Cohort of 3,744 SLE - 14% (578) had srSLE. Median SLEDAI-2K = 12, & decreased to 6 at 6m & 12m> < 25% achieved LLDAS & only 1% attained GC-free remission @ 12 mos https://t.co/7tehA27gyT https://t.co/yef4wCpqNf

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Dr. John Cush RheumNow ( View Tweet)
US CDC study of age-standardized mortality rate (ASMR) from 1990-2020, there were 39,496 deaths related to scleroderma (SSc) & and 5,163 from SSc w/ renal failure. Deaths lower in males (22%) than females w/ renal failure (78%). Mortality rate of SSc w? renal failure was https://t.co/OT3BHt3E85
Dr. John Cush RheumNow ( View Tweet)
RA Lung Disease Portends Poor Outcomes A retrospective Harvard affiliates study shows that rheumatoid arthritis (RA) patients with lung disease have higher mortality, especially respiratory and infection-related mortality than those without lung disease (LD). https://t.co/13h2u26ecb
Dr. John Cush RheumNow ( View Tweet)
PMR & GCA not assoc w/ increased mortality, Norway study of 274 isolated PMR (mean age 72 yrs) & 63 GCA (age 72 yrs) pts. After mean F/U 13.7 yrs 96% were deceased. Standardized mortality ratio was Not incr for PMR (0.97)or GCA (1.10), but men w/ PMR had , lower all-cause https://t.co/Mgq920awbD
Dr. John Cush RheumNow ( View Tweet)
🧬 Myositis-Specific Autoantibodies (MSAs) – 2025 Update MSAs aren’t just diagnostic—they predict phenotype, prognosis, & treatment response. 👇 Infographic #RheumTwitter #Myositis #MedEd @IhabFathiSulima @DrAkhilX https://t.co/91U5s88AdB

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Aravind Palraj Rheumat_Aravind ( View Tweet)
Molecular profiling of RA synovium predicts biologic responses Machine learning analysis of pre-treatment synovial tissue biopsy from RA patients starting either ETN, TCZ and RTX revealed high accuracy prediction of 16 week outcomes unique to each biologic. https://t.co/4d6NEY6JN6
Dr. John Cush RheumNow ( View Tweet)
1 in 5 Patients are Unaware of their Arthritis Diagnosis Current CDC numbers suggest that arthritis (any type) affects an estimated 67.1 million (27.9% ) adults in the USA. Interestingly, 1 in 5 do not know their arthritis subtype (21.6%, 14.4 million). https://t.co/G8zeP1K5X9 https://t.co/BdDFVSUuFf

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Dr. John Cush RheumNow ( View Tweet)
Stroke in patients with SLE is associated with a poorer outcome than matched controls in terms of functional recovery, recurrence, and mortality - study of 40 SLE vs 120 controls w/ CVA https://t.co/spBT1u6bfj https://t.co/eVNYBogJWz

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Dr. John Cush RheumNow ( View Tweet)
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