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DLE discoid lupus

A Pilot Trial of Anifrolumab in Discoid Lupus

d Jack Cush, MD

A research report in JAMA Dermatology describes the use of the type 1 interferon receptor inhibitor anifrolumab in patients with chronic discoid lupus erythematosus (DLE). 

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immune.activity.cytokine.jpg

Itaconate - A Potential New Immunosuppressive

d EurekAlert!

Researchers have revealed the modulatory effect of the anti-inflammatory metabolite itaconate (ITA) on T helper and T regulatory cells, which may lead to new therapeutic approaches to treating some autoimmune diseases.

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DMARDs,biologics,RA

Cost-Effective Use of Biological and Targeted Synthetic DMARDs

d Jack Cush, MD

An international task force of 13 European experts have developed evidence-based points to consider regarding the cost-effective use of biological and targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs) in the treatment of inflammatory rheumatic diseases (including rheumatoid arthritis, psoriatic arthritis and axial spondyloarthritis).

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hip.THR_.jpg

Optimal Timing of Elective Hip or Knee Arthroplasty

d ACR

The American College of Rheumatology (ACR) and the American Association of Hip and Knee Surgeons (AAHKS) released a summary of its new guideline titled “The Optimal Timing of Elective Hip or Knee Arthroplasty for Patients with Symptomatic Moderate to Severe Osteoarthritis or Osteonecrosis Who Have Failed Nonoperative Therapy.”

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joint.wrist_.pain_.CTS_.Carpal.jpg

Carpal Tunnel - Steroid injection vs. Night Splinting

d Jack Cush, MD

A prospective, pragmatic, open-label, randomized trial conducted by the UK National Health Service, studied interventions in patients with carpal tunnel syndrome (CTS) and found no advantage to either CTS corticosteroid injection (CSI) or night splinting (NS) as the initial treatment of CTS.

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marathon,runner,NYC

Marathon Running Not a Risk Factor for Arthritis

d MedPage Today

Intensity of distance running had no bearing on the prevalence of hip and knee osteoarthritis among participants in recent editions of the Chicago Marathon, researchers reported here.

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Cost-Effective Use of Biological and Targeted Synthetic DMARDs An international task force of experts have developed evidence-based points to consider regarding the cost-effective use of b/tsDMARDs in the treatment of inflammatory rheumatic diseases. https://t.co/jpxQggd89T https://t.co/zjer5QTN3C

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Optimal Timing of Elective Hip or Knee Arthroplasty https://t.co/Dz7qHxS5aO https://t.co/z7Q2oReEJs

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Congratulations to Dr. Georg Schett (University of Erlangen) upon receiving the 2023 Gottfried Wilhelm Leibniz Prize - highest honor from the DFG, German Research Foundation. Dr. Schett is famed for research on inflammation, autoimmunity & osteoimmunology https://t.co/Wq0EvhtvLW https://t.co/AWwCVCt4cm

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Lancet metanalysis shows pts infected w/ SARS-CoV2 are conferred very high degree of re-infx from pre-omicron variants, even after 40 weeks. Protection was lower for omicron BA.1 & declined over time. Protection from severe Dz was high for all variants. https://t.co/RNgYVWQfNo https://t.co/J8U37NYXPP

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Carpal Tunnel - Steroid injection vs. Night Splinting A randomized trial conducted by the UK National Health Service, studied interventions in patients with CTS and found no advantage to either CTS CSIor NS as the initial treatment of CTS. https://t.co/05AADf55uB https://t.co/m07xxffSfv

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Dr. John Cush RheumNow ( View Tweet)
Ccancer detection study in idiopathic inflammatory myositis: found w/in 3 yrs of onset 9/1011 (0.9%) CT chest & 12/657(1.8%) CT Dx cancer. Yield best w/ DM, TIF1γ pos. Yield very low age<40 yrs; high false(+) w/ antisynthetase synd & necrotizing myositis https://t.co/FCBwEYW1eT https://t.co/DAEj83xmam

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Dr. John Cush RheumNow ( View Tweet)
Marathon Running Not a Risk Factor for Arthritis Intensity of distance running had no bearing on the prevalence of hip and knee osteoarthritis among participants in recent editions of the Chicago Marathon, researchers reported here. https://t.co/GjgyncTGa6 https://t.co/cwIADHfNdv

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Dr. John Cush RheumNow ( View Tweet)
29 pts w/PsA Sine Psoriasis: 16F/13M, mean age 45 yrs w/ PsA ~6.2 yrs. 54% had 1st-degree relatives with PsA. 66% had DIP arthritis, 39% polyarticular, 36% oligoarticular, 25% were axial. Nail findings seen in 89%, enthesitis 59%, dactylitis 62% https://t.co/FPAqosYr9C https://t.co/xr692rSZZ1

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Dr. John Cush RheumNow ( View Tweet)
Retrospective insurance claims study of PMR & GCA pts. No cases PJP (pneumocystis) found in 547 Pt-Yrs F/U in 1168 GCA pts and 1 case found during 7,446 Pt-Yrs F/U in 15,575 PMR pts (incident 0.07 cases per 1,000 Pt-YRs). NO NEED FOR PJP prophylaxis! https://t.co/UFlKtm88Dj https://t.co/tFYusx0O4t

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Dr. John Cush RheumNow ( View Tweet)
Long-Term Survival of Idiopathic Inflammatory Myopathies A single center cohort study analyzed the outcome and survival of IIM patients and showed good 5 and 10 year survival but showed significant declined 15-25 years post-diagnosis. https://t.co/EmxRcDCIVn https://t.co/ngtMgrO9Jc

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Geo-epidemiology of Autoantibodies in Rheumatoid Arthritis A multinational study of RA patients shows a variety of post-translationally modified AMPA. While AMPA differed in different ethnic populations, their levels correlated with total serum IgG. https://t.co/QuA980svOO https://t.co/M7706bqxtl

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Abdominal Pain, Arthralgias, and a Poor Diet https://t.co/vEmQaaAP4J https://t.co/wqdf2kQ7Ak

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Dr. John Cush RheumNow ( View Tweet)
Higher Rehospitalization Rates in Younger SLE Patients A Medicare study shows that young adults with SLE exhibit very high 30-day rehospitalization rates (36%) that are significantly higher than older SLE patients and age matched non-SLE patients. https://t.co/5KvpgSxhzY https://t.co/6mDPcY0tkS

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Dr. John Cush RheumNow ( View Tweet)
Metanalysis of adverse PREG outcomes in 1675 women (1920 pregs) w/ anti-SSA/RO Abs - 4% preg termination, 5% spontaneous Ab, 26% preterm labor, 50% C-sect, 4% perinatal death, 3% IUGR, 7-12% heart block recurrence, 19% cut. neonatal LE https://t.co/pD2JkMsyVX https://t.co/oiSiwx9Ruj

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