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RheumNow Podcast – Coconspirators: RA and Lung Disease

Jack Cush, MD

Dr. Jack Cush reviews and discusses more than a dozen news and journal articles from the past week on RheumNow.com.

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DMARD Dropouts During COVID-19

Jack Cush, MD

A full year from the onset of the SARS-COV-2 pandemic, rheumatologists are still seeing the consequences of COVID, with many patients avoiding usual care, follow-up visits, routine lab testing and with many self-stopping their antirheumatic meds, because it seemed like the right thing to do.

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RheumNow Podcast – Mistakes with Steroids

Jack Cush, MD

Dr Jack Cush gives his spin on this week's RheumNews and Rheum Research from RheumNow.com.

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Overview of New VEXAS Syndrome

Jack Cush, MD

Medscape offers up an informative overview of the newly described syndrome called VEXAS discovered by researchers at the National Institutes of Health.

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Hypertension Unaffected by Urate Lowering Therapy

Jack Cush, MD

Does uric acid contribute to the risk of hypertension (HTN)?  A recent cohort trial shows that allopurinol in young adults does not sufficiently lower blood pressure (BP).

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Serious Infections Still Common in Vasculitis

MedPage Today

Serious infections occurred more frequently among patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis who were given induction therapy with cyclophosphamide compared with rituximab (Rituxan), Greek researchers found.

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RheumNow Podcast – Infection in ANCA-Associated Vasculitis (3.26.2021)

Jack Cush, MD

Dr. Jack Cush reviews the news, FDA Denials and journal articles from the past week on RheumNow.com.

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RECIPE Trial - Mycophenolate to Suppress Immunogenicity with Pegloticase in Gout

Jack Cush, MD

Pegloticase is indicated in the treatment of severe gout patients but prolonged use may be limited by immunogenicity to the PEG moiety. A randomized, controlled trial has shown that concomitant mycophenolate mofetil (MMF) may prolong the efficacy of pegloticase in gout.

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55 pts w/ Multi-joint osteonecrosis (>2 jts).( SLE 29%, ALL 11%, HIV 9%, EtOH 4%). Mean cumulative steroid dose >30 g over 5 yrs. Predictors of MJON was cumulative oral steroid dose (3.2% incr per 1000 mg. MJON risk incr 12 X w/ 2nd risk factor https://t.co/dqTPh2PV8V https://t.co/HTrSnZSefK

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Dr. John Cush RheumNow ( View Tweet)
Great #RNL2021 coverage from @uptoTate #RheumNow Not all that is pink and scaly is Psoriasis! DDx can include Sezary, Granuloma Annulare, Pemphigus, Erythroderma, paraneoplasm, eczema, lichen, basal cell CA, AKs, allergens, etc. Melodie Young, NP

Dr. John Cush RheumNow ( View Tweet)

Have you listened to last week's podcast? It's available wherever podcasts are available. Upadacitinib Wins in PsA https://t.co/Pd7QG6SsmJ https://t.co/3onAtZyoTt

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Dr. John Cush RheumNow ( View Tweet)
From @KDAO2011-- "Is it better to taper the steroids or leave it? SEMIRA study. Tapering off low dose steroids cause more flares and more treatment side effects. Dr. Buttgereit says keep your low dose steroids (prednisone 5 mg/day or less) https://t.co/RAYkVxGO9N #RNL2021"

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Dr. John Cush RheumNow ( View Tweet)

Beijing study of 207 RA patients starting DMARD and steroids (GC) shows after 3 years only 59% D/C GC (mean was 24 mos). Odds of stopping GC were 10% @ 6mos, 27% @Yr1, 48% @Yr 2 and 59% at 3 years. https://t.co/E2RchB9IAs https://t.co/uDEAqaM8GC

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Dr. John Cush RheumNow ( View Tweet)
From @KDAO2011 for #RNL2021 Is it better to taper the steroids or leave it? SEMIRA study. Tapering off low dose steroids cause more flares and more treatment side effects. Dr. Buttgereit says keep your low dose steroids (prednisone 5 mg/day or less) https://t.co/FpQnxUKWwF

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Dr. John Cush RheumNow ( View Tweet)

“Give as much glucocorticoids as necessary but as little as possible!” – Dr. F Buttgereit #RNL2021 #RheumNow Original tweet from Dr. Kathryn Dao @KDAO2011

Dr. John Cush RheumNow ( View Tweet)

Potent Topical Corticosteroids and the Risk of Osteoporotic Fractures https://t.co/OHohMKveik

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Dr. John Cush RheumNow ( View Tweet)

UTSW Rheum Gran Rounds - Dr. Ken Saag, Anakinra vs IA steroids @UTSWIMchief @KenSaag https://t.co/M2UCbyuJpb
Dr. John Cush RheumNow ( View Tweet)
Early RA pts given steroids (GC) do Not have short or long term benefits from GCs. 180 ERA pts given compared to 294 who did not. 5 yr F/U showed no differences in DAS28-CRP, HAQ or pain between groups. Steroids were used more in seronegative RA. https://t.co/CDUKDgsLRa

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Dr. John Cush RheumNow ( View Tweet)

News Feature: Potent Topical Corticosteroids and the Risk of Osteoporotic Fractures https://t.co/KazNPRXKNx https://t.co/pykBdbexzF

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Dr. John Cush RheumNow ( View Tweet)
@RheumNow #RNL2021 Dr. Buttgereit on steroids in RA: 2.5 mg/d of prednisone increase total steroid amount in the body by 100% - great therapeutic effect but comes w/plethora of side effects. Q: how do you feel out long term low dose steroids for RA?

Olga Petryna DrPetryna ( View Tweet)

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